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Graziano Colombo et al.
Biochimica et biophysica acta, 1850(1), 1-12 (2014-10-05)
Advanced oxidation protein products (AOPPs) are dityrosine cross-linked and carbonyl-containing protein products formed by the reaction of plasma proteins with chlorinated oxidants, such as hypochlorous acid (HOCl). Most studies consider human serum albumin (HSA) as the main protein responsible for
S Hassanpour et al.
British poultry science, 56(4), 443-451 (2015-06-09)
The aim of the current study was to investigate the interaction of the nitric oxide and cannabinoidergic systems on feeding behaviour in neonatal chicken. A total of 6 experiments were designed to evaluate the interaction between cannabinoidergic and nitrergic systems
Vincent Geoghegan et al.
Nature communications, 6, 6758-6758 (2015-04-08)
The impact of protein arginine methylation on the regulation of immune functions is virtually unknown. Here, we apply a novel method—isomethionine methyl-SILAC—coupled with antibody-mediated arginine-methylated peptide enrichment to identify methylated peptides in human T cells by mass spectrometry. This approach
Paolo Ferruti et al.
Macromolecular bioscience, 14(3), 390-400 (2014-05-14)
A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N'-methylenebisacrylamide. Chain-extension of acrylamide end-capped L-ARGO7 oligomers with piperazine leads to high-molecular-weight copolymers in which L-arginine maintains its absolute configuration. Acid/base properties of L-ARGO7 polymers show
PRRT2 and hemiplegic migraine: a complex association.
Nadine Pelzer et al.
Neurology, 83(3), 288-290 (2014-06-15)
Sherri Wood et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2899-2908 (2015-02-18)
Rejection remains a major clinical challenge limiting allograft survival after solid organ transplantation. Both cellular and humoral immunity contribute to this complication, with increased recognition of Ab-mediated damage during acute and chronic rejection. Using a mouse model of MHC-mismatched heart
Sunil Kumar et al.
Applied and environmental microbiology, 81(16), 5593-5603 (2015-06-07)
Agmatine, a significant polyamine in bacteria and plants, mostly arises from the decarboxylation of arginine. The functional importance of agmatine in fungi is poorly understood. The metabolism of agmatine and related guanidinium group-containing compounds in Aspergillus niger was explored through
Stefano Romano et al.
PloS one, 9(5), e96038-e96038 (2014-05-03)
Oceanic dissolved organic matter (DOM) is an assemblage of reduced carbon compounds, which results from biotic and abiotic processes. The biotic processes consist in either release or uptake of specific molecules by marine organisms. Heterotrophic bacteria have been mostly considered
The challenge of complexity and arginine metabolism.
Francesco Saverio Dioguardi
The American journal of clinical nutrition, 98(2), 507-508 (2013-07-23)
Tingting Wang et al.
Current pharmaceutical biotechnology, 16(5), 430-439 (2014-11-11)
The purpose of this study was to observe if luteolin could affect the behavior of cardiac fibroblasts (CFs) on myocardial fibrosis stimulated by angiotensin II (Ang II) and investigate the mechanism involved. MTT was used to observe the CFs viability
Gabriela Valenzuela-Barra et al.
Journal of ethnopharmacology, 168, 37-44 (2015-04-04)
Propolis has long been used as a popular folk medicine due to its wide spectrum of alleged biological and pharmaceutical properties. In Chile, propolis is widely used by folklore medicine as an anti-inflammatory agent; however, this property has not been
Krishnan Suresh Kumar et al.
European journal of medicinal chemistry, 45(11), 5474-5479 (2010-08-21)
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex
María A Duque-Correa et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(38), E4024-E4032 (2014-09-10)
Lung granulomas develop upon Mycobacterium tuberculosis (Mtb) infection as a hallmark of human tuberculosis (TB). They are structured aggregates consisting mainly of Mtb-infected and -uninfected macrophages and Mtb-specific T cells. The production of NO by granuloma macrophages expressing nitric oxide
Nurul Nadzirin et al.
Nucleic acids research, 41(Web Server issue), W432-W440 (2013-05-30)
We describe a server that allows the interrogation of the Protein Data Bank for hypothetical 3D side chain patterns that are not limited to known patterns from existing 3D structures. A minimal side chain description allows a variety of side
Mustafa Erinc Sitar et al.
Amino acids, 47(9), 1983-1993 (2015-04-30)
Free, non-protein bound asymmetrically guanidine-dimethylated arginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. Human erythrocytic membrane comprises considerable amounts of large (>50 kDa) ADMA-containing proteins. Location in the erythrocyte membrane and identity and physiological functions of ADMA-containing
Umarat Srisawat et al.
Biological & pharmaceutical bulletin, 38(5), 753-762 (2015-05-08)
Ischemia and subsequent reperfusion are known to impair renal function. We examined several agents that might prevent renal impairment or enhance the recovery of renal function after ischemia/reperfusion injury in rats. Different degrees of preventive effects were observed in rats
Krishna R Veeramah et al.
Epilepsia, 54(7), 1270-1281 (2013-05-08)
The management of epilepsy in children is particularly challenging when seizures are resistant to antiepileptic medications, or undergo many changes in seizure type over time, or have comorbid cognitive, behavioral, or motor deficits. Despite efforts to classify such epilepsies based
David B Beck et al.
Journal of proteome research, 13(12), 6135-6143 (2014-10-15)
Accurate and sensitive detection of protein-protein and protein-RNA interactions is key to understanding their biological functions. Traditional methods to identify these interactions require cell lysis and biochemical manipulations that exclude cellular compartments that cannot be solubilized under mild conditions. Here
Joern Lausen
Critical reviews in eukaryotic gene expression, 23(3), 265-274 (2013-07-25)
Hematopoietic differentiation is directed by transcription factors such as RUNX1. RUNX1 binds to specific DNA binding sites in regulatory elements of genes and recruits epigenetic cofactors to target loci. In this way histone modification patterns and the chromatin environment are
Yipin Wu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(7), R747-R756 (2015-08-01)
Inwardly rectifying potassium channels play essential roles in renal physiology across phyla. Barium-sensitive K(+) conductances are found on the basolateral membrane of a variety of insect Malpighian (renal) tubules, including Drosophila melanogaster. We found that barium decreases the lumen-positive transepithelial
Ruben Esse et al.
Biochimica et biophysica acta, 1832(10), 1708-1714 (2013-05-28)
Accumulation of S-adenosylhomocysteine (AdoHcy), the homocysteine (Hcy) precursor and a potent methyltransferase inhibitor, may mediate the neurological and vascular complications associated with elevated Hcy. Protein arginine methylation is a crucial post-translational modification and generates monomethylarginine (MMA) and dimethylarginine (asymmetric, ADMA
James Rae et al.
eLife, 10 (2021-04-28)
Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and robust genetic tags for ultrastructural localization by electron microscopy (EM). Here, we describe a
Shuyu Wang et al.
Science (New York, N.Y.), 347(6218), 188-194 (2015-01-09)
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the translocation of mTORC1 to the lysosomal
Jason Fan et al.
Molecular metabolism, 34, 97-111 (2020-03-18)
Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic environment with impaired mitochondrial function remains unclear. Here
Surgery, 156(4), 869-870 (2014-09-23)
Monika Gibis et al.
Journal of food science, 80(11), C2430-C2439 (2015-10-08)
The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the
Lei Fang et al.
Journal of proteome research, 7(11), 4914-4925 (2008-10-15)
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. Despite of its significance, current understanding of the biological functions and regulatory mechanisms of the CSN complex
Ryan C Hill et al.
Journal of agricultural and food chemistry, 63(33), 7450-7461 (2015-08-04)
Currently, traditional immunochemistry technologies such as enzyme-linked immunosorbent assays (ELISA) are the predominant analytical tool used to measure levels of recombinant proteins expressed in genetically engineered (GE) plants. Recent advances in agricultural biotechnology have created a need to develop methods
Roberto Maya-Martinez et al.
Biochemical and biophysical research communications, 456(2), 695-699 (2014-12-20)
AL amyloidosis is the most common amyloid systemic disease and it is characterized by the deposition of immunoglobulin light chain amyloid fibers in different organs, causing organ failure. The immunoglobulin light chain germinal line 6a has been observed to over-express
Lauren Platts et al.
International journal of pharmaceutics, 486(1-2), 131-135 (2015-03-31)
Three distinct interactions between the amino acid arginine and a protein explain arginine's ability to modulate the thermal stability of proteins. Arginine's effect on the protein unfolding behaves like the sum of its constituent parts, glycine and the guanidinium ion.
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