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Endocrinology (2001)
D Vieau et al.
The Journal of clinical endocrinology and metabolism, 79(5), 1503-1506 (1994-11-01)
POMC processing is frequently altered in ACTH-secreting nonpituitary tumors in which intermediate lobe-like peptides such as corticotropin-like intermediate lobe peptide (CLIP) are occasionally generated. In rodent pituitaries, the exclusive presence of prohormone convertase PC2 in the melanotrophs of the intermediate
B el Kafi et al.
Brain research, 686(2), 150-159 (1995-07-24)
Two peptides known for their hypnogenic properties, CLIP (corticotropin-like intermediate lobe peptide or ACTH 18-39) or VIP (vasoactive intestinal polypeptide), were injected locally into the nucleus raphe dorsalis (nRD) of rats pretreated with p-chlorophenylalanine (PCPA). During the dark period, the
C Bonnet et al.
Brain research, 751(1), 54-63 (1997-03-14)
A 1 h immobilization stress (IS) was imposed to rats at the beginning of the dark period, i.e., when the animals start to be active. The IS was accompanied by an intense polygraphic waking and followed, over 12 h of
Chuchu Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(12), E2524-E2532 (2017-03-08)
Pain-producing animal venoms contain evolutionarily honed toxins that can be exploited to study and manipulate somatosensory and nociceptive signaling pathways. From a functional screen, we have identified a secreted phospholipase A2 (sPLA2)-like protein, BomoTx, from the Brazilian lancehead pit viper
E J Takach et al.
Journal of protein chemistry, 16(5), 363-369 (1997-07-01)
Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass range are unsurpassed, but mass measurement accuracy and resolution have been limited. With delayed extraction and a reflecting analyzer, mass measurements
James B Harkins et al.
Analytical chemistry, 80(8), 2734-2743 (2008-03-12)
The preparation of complex biological samples for high-throughput mass spectrometric analyses remains a significant bottleneck, limiting advancement of the capabilities of mass spectrometry (MS) and ultimately limiting development of novel clinical assays. The removal of interfering species (e.g., salts, detergents
Jessica L Costa et al.
General and comparative endocrinology, 136(1), 12-16 (2004-02-26)
alpha-Melanocyte stimulating hormone (MSH) and adrenocorticotropin (ACTH)1-24, the minimal ACTH sequence required for full activity, differ only by the 10 C-terminal amino acids of ACTH1-24. Interestingly, these ten C-terminal residues have been highly conserved throughout vertebrate evolution. To understand the
V V Grigoriev et al.
Bulletin of experimental biology and medicine, 147(3), 319-322 (2009-06-17)
We studied the effect of corticotropin-like intermediate lobe peptide (CLIP) on presynaptic NMDA receptors and postsynaptic GABA, NMDA, and AMPA receptors in rat brain. CLIP inhibited presynaptic and postsynaptic NMDA receptors, but potentiated postsynaptic GABA and AMPA receptors. Our results
Fangqiao Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 509, 101-107 (2020-06-13)
Salivary peptidome profiling analysis has advantages of simplicity and non-invasiveness and great potentiality for screening, monitoring or primary diagnosis of diseases, but may be subjected to change against interferences like diet. We conducted a 5-day study to investigate the influence
Mario Perello et al.
American journal of physiology. Endocrinology and metabolism, 292(5), E1348-E1357 (2007-01-18)
The alpha-melanocyte-stimulating hormone (alpha-MSH), derived from proopiomelanocortin (POMC), is generated by a posttranslational processing mechanism involving the prohormone convertases (PCs) PC1/3 and PC2. In the brain, alpha-MSH is produced in the arcuate nucleus (ARC) of the hypothalamus and in the
R Coveñas et al.
Journal of chemical neuroanatomy, 11(3), 191-197 (1996-09-01)
Using an indirect immunoperoxidase technique, the location of cell bodies and fibres containing adrenocorticotropin hormone/corticotropin-like intermediate lobe peptide (ACTH/CLIP) was studied in the cat diencephalon. Immunoreactivity was observed in several diencephalic nuclei of the cat in which no immunoreactivity has
M Takayama
Journal of the American Society for Mass Spectrometry, 12(4), 420-427 (2001-04-27)
In-source decay (ISD) of peptides, coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, has been examined to determine the influence of the matrix, the susceptibility of amino-acid residues to ISD, and the effect of extraction delay times. Out of nine
Amandine Descamps et al.
Brain research, 1335, 14-23 (2010-04-13)
It is now known that after an immobilization stress (IS) of short duration (1h), adult rats exhibit a significant rapid eye movement (REM) sleep rebound. In this study, we examined this phenomenon in aged animals. We found that aged rats
Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices.
Sawicki LA, et al.
ACS biomaterials science & engineering, 4(3), 836-845 (2018)
L Léger et al.
Neuroscience letters, 222(3), 155-158 (1997-02-07)
The relationships of the corticotropin-like intermediate lobe peptide (CLIP)/ACTH-immunoreactive axons with the serotoninergic and non-serotoninergic neurons in the dorsal raphe nucleus of the rat were examined by means of a double label immunocytochemical method. It is suggested that the rare
J F Massias et al.
European journal of endocrinology, 131(4), 341-346 (1994-10-01)
Many peptides contribute to the heterogeneity of immunoreactive adrenocorticotropin (ACTH) in man. The use of a radioimmunoassay (RIA) specifically directed against the C-terminal end of ACTH allowed us to study precisely the following four peptides: ACTH itself, corticotropin-like intermediary lobe
Simon Ekström et al.
Journal of mass spectrometry : JMS, 42(11), 1445-1452 (2007-10-26)
A polymer microfabricated proteomic sample preparation and MALDI MS sample presentation device, the integrated selective enrichment target (ISET), comprising an array of perforated nanovials is reported. Each perforated nanovial can be filled with selective extraction media (microbeads) for purification and
Salivary peptidome profiling for diagnosis of severe early childhood caries.
Sun X, et al.
Journal of Translational Medicine, 14(1), 240-240 (2016)
Attila Karsi et al.
General and comparative endocrinology, 137(3), 312-321 (2004-06-18)
Channel catfish (Ictalurus punctatus) proopiomelanocortin (POMC) cDNA was cloned to investigate its structure, evolution, and expression in different tissues. POMC is an important gene in the hypothalamus-pituitary-adrenal axis, the main mediator of the stress response. POMC gene was isolated from
M Davenport et al.
The Journal of endocrinology, 146(1), 177-182 (1995-07-01)
The mechanisms which initiate and maintain the energy partitioning into maternal tissues during pregnancy are unknown. The present study shows that in each of the weeks prior to pregnancy in the rat, plasma beta-cell tropin (beta CT) concentrations (nmol/l) were
R Coveñas et al.
Peptides, 18(7), 965-970 (1997-01-01)
The distribution of adrenocorticotropin hormone/corticotropin-like intermediate lobe peptide was studied in the cat brain stem, using an indirect immunoperoxidase technique. No immunoreactive cell bodies were observed. However, a high density of immunoreactive fibers was found in the periaqueductal gray, the
Chang Tian et al.
PloS one, 12(8), e0182712-e0182712 (2017-08-16)
This study aimed to identify differences of peptide profiles in stimulated whole saliva among children with and without occurrence of new carious lesions, and to provide a simple way for early diagnosis and prevention of the relapse of severe early
B el Kafi et al.
Brain research, 637(1-2), 211-221 (1994-02-21)
Several peptides exhibiting hypnogenic properties when administered i.p., i.v. or i.c.v. are now known. No data, however, are available concerning their targets in the brain. In the present work we hypothesize that the nucleus raphe dorsalis (nRD) may be one
L Léger et al.
Neuroscience letters, 174(2), 137-140 (1994-06-20)
The injection of corticotrophin-like intermediate lobe peptide (CLIP) in the lateral ventricle or the dorsal raphe nucleus (DRN) of the rat is followed by a significant increase in the amount of paradoxical sleep. In the DRN, CLIP would act through
C Coffin et al.
The Journal of clinical endocrinology and metabolism, 86(7), 2997-3000 (2001-07-10)
The increases in the level of plasma lipotropin (LPH) and in the LPH/ACTH ratio are considered diagnostic tools in ectopic ACTH syndrome. However, plasma ACTH is also elevated in this syndrome. We report a case of a small carcinoid tumor
Akiyoshi Takahashi et al.
General and comparative endocrinology, 145(3), 280-286 (2005-10-26)
Proopiomelanocortin (POMC) is a common precursor of adrenocorticotropic hormone (ACTH), melanophore-stimulating hormone (MSH), and endorphin (END). In pituitary gland, POMC receives posttranslational processing by which different peptides are generated in the pars distalis (PD) and pars intermedia (PI). Recently, we
V V Grigoriev et al.
Bulletin of experimental biology and medicine, 154(1), 10-12 (2013-01-19)
We studied the effect of somatostatin on presinaptic NMDA receptors and postsinaptic GABA, NMDA, and AMPA receptors in rat brain. It was shown that somatostatin inhibits NMDA-induced (45)Ca(2+) uptake into synaptosomes isolated from rat brain cortex (IC50=2.8×10(-11) M). Somatostatin potentiates
Wolfram Wetzel et al.
The European journal of neuroscience, 18(9), 2611-2617 (2003-11-19)
Growing evidence supports the idea that sleep following learning is critically involved in memory formation. Recent studies suggest that information acquired during waking is reactivated and possibly consolidated during subsequent sleep, especially during rapid-eye movement (REM) or paradoxical sleep (PS).
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