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Xue Bao et al.
The EMBO journal, 40(20), e107966-e107966 (2021-09-15)
Phosphatidylcholine (PC) is an abundant membrane lipid component in most eukaryotes, including yeast, and has been assigned multiple functions in addition to acting as building block of the lipid bilayer. Here, by isolating S. cerevisiae suppressor mutants that exhibit robust growth
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
Maiko Inaba et al.
Biochimica et biophysica acta, 1841(1), 121-131 (2013-10-15)
Glycerophospholipids are known to be hydrolyzed in the intestinal lumen into free fatty acids and lysophospholipids that are then absorbed by the intestinal epithelial cells. A monolayer of enterocyte-differentiated Caco-2 cell is often used to assess the intestinal bioavailability of
Cydne A Perry et al.
The Journal of nutrition, 144(12), 1977-1984 (2014-08-15)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women
Ningfeng Tang et al.
Alcoholism, clinical and experimental research, 38(11), 2722-2730 (2014-11-26)
Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the functions of L1 cell adhesion molecule (L1). These functions include enhancement
Marino Cimitan et al.
Clinical nuclear medicine, 38(9), 752-754 (2013-07-17)
We report a case of a 62-year-old man with biochemical recurrence of prostate cancer disease, investigated by fluorine-18-Choline ((18)F-FCH) PET/CT. (18)F-FCH PET/CT demonstrated focal increased uptake of (18)F-FCH inside the right testis, suggestive for distant recurrent disease. On testis removal
Marcelo Mamede et al.
Clinical nuclear medicine, 38(9), e342-e345 (2013-06-26)
This study aims to evaluate the role of (11)C-choline PET/CT in patients with biochemical relapse after radical prostatectomy (RP) showing prostate-specific antigen (PSA) values lower than 0.5 ng/mL. We performed (11)C-choline PET/CT in 71 consecutive patients previously treated with RP
Wanhu Li et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12353-12360 (2014-09-04)
The aim of the present study is to evaluate the role of (11)C-choline positron emission tomography/computed tomography (PET/CT) in detecting tumor recurrence and predicting survival in post-treatment patients with high-grade gliomas. A total of 16 previously treated histopathologically proven high-grade
Shingo Kobayashi et al.
Biochimica et biophysica acta, 1841(9), 1264-1271 (2014-05-17)
In eukaryotic cells, phospholipids are synthesized exclusively in the defined organelles specific for each phospholipid species. To explain the reason for this compartmental specificity in the case of phosphatidylcholine (PC) synthesis, we constructed and characterized a Saccharomyces cerevisiae strain that
F Granata et al.
The neuroradiology journal, 26(3), 277-283 (2013-07-19)
The cognitive dysmetria theory suggests a disconnectivity between the dorsolateral prefrontal cortex, thalami and vermis to explain the pathophysiology of schizophrenia. This study investigated the metabolic integrity of this neurologic circuit in patients with schizophrenia using proton magnetic resonance spectroscopy
Baokun Tang et al.
Journal of chromatographic science, 53(5), 836-840 (2014-09-18)
Three flavones (quercetin, myricetin and amentoflavone) were extracted from Chamaecyparis obtusa leaves using deep eutectic solvents (DESs) as additives to conventional extractions solvents. Sixteen DESs were synthesized from different salts and hydrogen bond donors. In addition, C. obtusa was extracted
Paula Dominguez-Salas et al.
The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)
Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were
Ilias Patmanidis et al.
Journal of molecular graphics & modelling, 41, 68-71 (2013-03-19)
Folding simulations of a choline-binding peptide derived from the Streptococcus pneumoniae LytA protein converged to a model of the peptide's folded state structure which is in outstanding agreement with the experimentally-determined structures, reaching values for the root mean squared deviation
Growth and nutrition in children with food allergy requiring amino acid-based nutritional formulas.
Karen A Robbins et al.
The Journal of allergy and clinical immunology, 134(6), 1463-1466 (2014-12-03)
O Hemminki et al.
International journal of cancer, 134(12), 2878-2890 (2013-11-20)
At present, it is not possible to reliably identify patients who will benefit from oncolytic virus treatments. Conventional modalities such as computed tomography (CT), which measure tumor size, are unreliable owing to inflammation-induced tumor swelling. We hypothesized that magnetic resonance
Kristin Zscharnack et al.
Analytica chimica acta, 854, 145-152 (2014-12-07)
H2O2 is a widely occurring molecule which is also a byproduct of a number of enzymatic reactions. It can therefore be used to quantify the corresponding enzymatic substrates. In this study, the time-resolved fluorescence emission of a previously described complex
Xian-Fei Zeng et al.
Research in microbiology, 165(8), 630-638 (2014-10-07)
LicC has been identified as a virulence factor of Streptococcus pneumoniae. However, its role in virulence is still not fully understood because deletion of licC is lethal for the bacterium. In this study, a mutant with 78-bp truncation at the
Alexandra Petruş et al.
Canadian journal of physiology and pharmacology, 93(9), 811-818 (2015-09-02)
A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury. Several mechanisms have been postulated to be responsible for cardioprotection, including the modulation of
Dale A Fortin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16698-16712 (2014-12-17)
Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy termed endogenous labeling via exon duplication (ENABLED), which can be used to fluorescently label endogenous proteins with
Alexandra Deviers et al.
International journal of radiation oncology, biology, physics, 90(2), 385-393 (2014-08-12)
Because lactate accumulation is considered a surrogate for hypoxia and tumor radiation resistance, we studied the spatial distribution of the lactate-to-N-acetyl-aspartate ratio (LNR) before radiation therapy (RT) with 3D proton magnetic resonance spectroscopic imaging (3D-(1)H-MRSI) and assessed its impact on
Amy Eccles et al.
Clinical nuclear medicine, 38(9), 755-757 (2013-07-17)
A 63-year-old man underwent a (18)F-fluorocholine ((18)F-FCH) PET/CT for staging assessment of a high-risk locally advanced prostate cancer with an equivocal node on conventional workup (Gleason 4 + 5, PSA 11.1; T3b, N(0/1), M(0) on standard staging investigations). (18)F-FCH-avid disease
A Collin de l'Hortet et al.
Endocrinology, 155(7), 2545-2554 (2014-04-09)
GH pathway has been shown to play a major role in liver regeneration through the control of epidermal growth factor receptor (EGFR) activation. This pathway is down-regulated in nonalcoholic fatty liver disease. Because regeneration is known to be impaired in
Jing-Li Gan et al.
Psychiatry research, 223(1), 23-27 (2014-05-17)
Early onset schizophrenia (EOS) is often associated with poorer outcomes, including lack of school education, higher risk of mental disability and resistance to treatment. But the knowledge of the neurobiological mechanism of EOS is limited. Here, using proton magnetic resonance
Tatiana V Vygodina et al.
Biochimica et biophysica acta, 1837(7), 1188-1195 (2014-03-13)
Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of heme a, which allowed earlier the determination of the kinetic
Ling Li et al.
Macromolecular bioscience, 15(7), 912-926 (2015-03-25)
Herein, an effective gene delivery vector phosphorylcholine and macrocyclic polyamine grafted chitosan (PC-g(6)-Cs-g(2)-Cyclen) was developed. Chemical characterization of product PC-g(6)-Cs-g(2)-Cyclen was performed by NMR, FT-IR, gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) analysis. PC-g(6)-Cs-g(2)-Cyclen could more efficiently bind
Katherine D Weaver et al.
Biochimica et biophysica acta, 1828(8), 1856-1862 (2013-04-02)
To better understand the relationship between the relative cytotoxicity of diluted ionic liquids and their specific interaction with biological membranes, the thermotropic behavior of model lipid membrane systems formulated in a series of choline based organic salts was investigated. Unilamellar
Hussain Mohamad Awwad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 41-45 (2014-03-29)
We aimed at developing a method for the measurement of choline and its metabolites in whole blood (WB). After an extraction step, quantification of choline, betaine, and dimethylglycine (DMG) was performed using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
Xin Jin et al.
Acta pharmacologica Sinica, 36(12), 1416-1425 (2015-11-17)
To determine whether administration of choline could attenuate brain injury in a rat model of ischemic stroke and the underlying mechanisms. A rat model of ischemic stroke was established through permanent middle cerebral artery occlusion (pMCAO). After the surgery, the
Mads H Poulsen et al.
BJU international, 114(6), 818-823 (2013-12-10)
To compare the diagnostic accuracy of the following imaging techniques in the detection of spine metastases, using magnetic resonance imaging (MRI) as a reference: whole-body bone scintigraphy (WBS) with technetium-99m-MDP, [18F]-sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) and
David J Lin et al.
Journal of neurophysiology, 112(4), 942-950 (2014-05-23)
Recent studies have demonstrated that vision influences the functional remodeling of the mouse retinogeniculate synapse, the connection between retinal ganglion cells and thalamic relay neurons in the dorsal lateral geniculate nucleus (LGN). Initially, each relay neuron receives a large number
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