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Andreas Hecker et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2325-2334 (2015-07-24)
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Amy Eccles et al.
Clinical nuclear medicine, 38(9), 755-757 (2013-07-17)
A 63-year-old man underwent a (18)F-fluorocholine ((18)F-FCH) PET/CT for staging assessment of a high-risk locally advanced prostate cancer with an equivocal node on conventional workup (Gleason 4 + 5, PSA 11.1; T3b, N(0/1), M(0) on standard staging investigations). (18)F-FCH-avid disease
A Collin de l'Hortet et al.
Endocrinology, 155(7), 2545-2554 (2014-04-09)
GH pathway has been shown to play a major role in liver regeneration through the control of epidermal growth factor receptor (EGFR) activation. This pathway is down-regulated in nonalcoholic fatty liver disease. Because regeneration is known to be impaired in
Francesca Froldi et al.
The EMBO journal, 38(7) (2019-02-26)
Rewired metabolism of glutamine in cancer has been well documented, but less is known about other amino acids such as histidine. Here, we use Drosophila cancer models to show that decreasing the concentration of histidine in the diet strongly inhibits
O Hemminki et al.
International journal of cancer, 134(12), 2878-2890 (2013-11-20)
At present, it is not possible to reliably identify patients who will benefit from oncolytic virus treatments. Conventional modalities such as computed tomography (CT), which measure tumor size, are unreliable owing to inflammation-induced tumor swelling. We hypothesized that magnetic resonance
Marina Hodolič et al.
Clinical nuclear medicine, 38(9), 739-740 (2013-07-03)
A 59-year-old man presented with frequent urination. Six months ago, his prostate-specific antigen (PSA) was 1.56 ng/mL; currently it is 3.5 ng/mL (PSA doubling time = 6 months; PSA velocity = 0.19 ng/mL/mo). Biopsy revealed aggressive prostate cancer (Gleason score
Ilias Patmanidis et al.
Journal of molecular graphics & modelling, 41, 68-71 (2013-03-19)
Folding simulations of a choline-binding peptide derived from the Streptococcus pneumoniae LytA protein converged to a model of the peptide's folded state structure which is in outstanding agreement with the experimentally-determined structures, reaching values for the root mean squared deviation
Ningfeng Tang et al.
Alcoholism, clinical and experimental research, 38(11), 2722-2730 (2014-11-26)
Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the functions of L1 cell adhesion molecule (L1). These functions include enhancement
Cydne A Perry et al.
The Journal of nutrition, 144(12), 1977-1984 (2014-08-15)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women
Elisabeth Traiffort et al.
Molecular aspects of medicine, 34(2-3), 646-654 (2013-03-20)
The Na(+)-independent, high affinity choline carrier system proposed to supply choline for the synthesis of cell membrane phospholipids was recently associated with SLC44 family members (SLC44A1-5) also called choline-like transporter family. SLC44A1 is widely expressed throughout the nervous system in
Michele Visentin et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 145-151 (2015-09-04)
The somatostatin analog octreotide can lead to hyperbilirubinemia without evidence of liver injury. Here we investigate whether octreotide inhibits the main sinusoidal/canalicular bilirubin carriers and whether it is a transport substrate. Octreotide showed the most potent inhibitory effect toward OATP1B1-mediated
Vincent A van der Mark et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2378-2386 (2014-09-23)
Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1 (BRIC1). Apart from cholestasis, many patients also suffer from diarrhea
Andrew J Ocque et al.
Journal of pharmaceutical and biomedical analysis, 109, 128-135 (2015-03-15)
A simple, sensitive, and precise ultra-high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of trimethylamine N-oxide, choline, and betaine in human plasma and urine. Sample preparation involved protein precipitation with methanol containing internal
Marcelo Mamede et al.
Clinical nuclear medicine, 38(9), e342-e345 (2013-06-26)
This study aims to evaluate the role of (11)C-choline PET/CT in patients with biochemical relapse after radical prostatectomy (RP) showing prostate-specific antigen (PSA) values lower than 0.5 ng/mL. We performed (11)C-choline PET/CT in 71 consecutive patients previously treated with RP
Marino Cimitan et al.
Clinical nuclear medicine, 38(9), 752-754 (2013-07-17)
We report a case of a 62-year-old man with biochemical recurrence of prostate cancer disease, investigated by fluorine-18-Choline ((18)F-FCH) PET/CT. (18)F-FCH PET/CT demonstrated focal increased uptake of (18)F-FCH inside the right testis, suggestive for distant recurrent disease. On testis removal
Giles S Kendall et al.
Radiology, 271(1), 230-238 (2014-01-31)
To determine (a) whether diffuse white matter injury of prematurity is associated with an increased choline (Cho)-to-creatine (Cr) ratio and a reduced N-acetylaspartate (NAA)-to-Cho ratio and whether these measures can be used as biomarkers of outcome and (b) if changes
Lihui Zhao et al.
Frontiers in pharmacology, 10, 1386-1386 (2019-12-19)
Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults. However, whether choline offers similar beneficial effects via the same mechanism in cardiac fibrosis remained unexplored. The
Tatiana V Vygodina et al.
Biochimica et biophysica acta, 1837(7), 1188-1195 (2014-03-13)
Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of heme a, which allowed earlier the determination of the kinetic
Jing-Li Gan et al.
Psychiatry research, 223(1), 23-27 (2014-05-17)
Early onset schizophrenia (EOS) is often associated with poorer outcomes, including lack of school education, higher risk of mental disability and resistance to treatment. But the knowledge of the neurobiological mechanism of EOS is limited. Here, using proton magnetic resonance
Hussain Mohamad Awwad et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 41-45 (2014-03-29)
We aimed at developing a method for the measurement of choline and its metabolites in whole blood (WB). After an extraction step, quantification of choline, betaine, and dimethylglycine (DMG) was performed using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
Growth and nutrition in children with food allergy requiring amino acid-based nutritional formulas.
Karen A Robbins et al.
The Journal of allergy and clinical immunology, 134(6), 1463-1466 (2014-12-03)
Xin Jin et al.
Acta pharmacologica Sinica, 36(12), 1416-1425 (2015-11-17)
To determine whether administration of choline could attenuate brain injury in a rat model of ischemic stroke and the underlying mechanisms. A rat model of ischemic stroke was established through permanent middle cerebral artery occlusion (pMCAO). After the surgery, the
Mads H Poulsen et al.
BJU international, 114(6), 818-823 (2013-12-10)
To compare the diagnostic accuracy of the following imaging techniques in the detection of spine metastases, using magnetic resonance imaging (MRI) as a reference: whole-body bone scintigraphy (WBS) with technetium-99m-MDP, [18F]-sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) and
Ling Li et al.
Macromolecular bioscience, 15(7), 912-926 (2015-03-25)
Herein, an effective gene delivery vector phosphorylcholine and macrocyclic polyamine grafted chitosan (PC-g(6)-Cs-g(2)-Cyclen) was developed. Chemical characterization of product PC-g(6)-Cs-g(2)-Cyclen was performed by NMR, FT-IR, gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) analysis. PC-g(6)-Cs-g(2)-Cyclen could more efficiently bind
Katherine D Weaver et al.
Biochimica et biophysica acta, 1828(8), 1856-1862 (2013-04-02)
To better understand the relationship between the relative cytotoxicity of diluted ionic liquids and their specific interaction with biological membranes, the thermotropic behavior of model lipid membrane systems formulated in a series of choline based organic salts was investigated. Unilamellar
Kristin Zscharnack et al.
Analytica chimica acta, 854, 145-152 (2014-12-07)
H2O2 is a widely occurring molecule which is also a byproduct of a number of enzymatic reactions. It can therefore be used to quantify the corresponding enzymatic substrates. In this study, the time-resolved fluorescence emission of a previously described complex
N Andres Parra et al.
International journal of radiation oncology, biology, physics, 90(2), 376-384 (2014-07-30)
Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by
Femke S den Boon et al.
Pflugers Archiv : European journal of physiology, 467(7), 1551-1564 (2014-08-02)
Activation of the endocannabinoid (eCB) system by exogenous cannabinoids (drug abuse) can alter the physiology of the brain circuits involved in higher-order cognitive functions such as the medial prefrontal cortex (mPFC). A proper balance between excitation and inhibition (E/I balance)
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
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