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Anders Burild et al.
Scandinavian journal of clinical and laboratory investigation, 74(5), 418-423 (2014-04-23)
Serum 25-hydroxy-vitamin D is the established biomarker of vitamin D status although serum concentrations of vitamin D and 24,25-dihydroxyvitamin D may also be of interest to understand the in vivo kinetics of serum 25-hydroxyvitamin D. An LC-MS/MS method was developed
Sara S Oberhelman et al.
Mayo Clinic proceedings, 88(12), 1378-1387 (2013-12-03)
To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Forty mothers with exclusively breast-fed infants were randomized to receive oral
Andy de Jong et al.
Acta orthopaedica Belgica, 79(5), 578-586 (2013-12-20)
Assessment and treatment of osteoporosis are recommended following hip fracture. Osteoporosis treatment assumes an adequate calcium intake and a normal vitamin D plasma level. The authors conducted a study in three phases. Phase I: circulating 25-hydroxyvitamin D levels were retrospectively
Umon Agata et al.
Journal of nutritional science and vitaminology, 61(5), 391-399 (2015-12-08)
Reduced estrogen secretion and low calcium (Ca) intake are risk factors for bone loss and arterial calcification in female rodents. To evaluate the effects of Ca intake at different amounts on bone mass changes and arterial calcification, 8-wk-old female Wistar
Ahmed Alsaqr et al.
AAPS PharmSciTech, 16(4), 963-972 (2015-01-23)
Transdermal delivery of therapeutic amounts of vitamin D3 is proposed to overcome its variable oral bioavailability, especially for people who suffer from fat malabsorption. The main challenge for this delivery route is to overcome the barrier properties of skin, especially
Mu-En Lin et al.
The American journal of pathology, 185(7), 1958-1969 (2015-05-20)
Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is preceded by expression of runt-related transcription factor 2 (Runx2)
Cristhian R L Francisco et al.
Food chemistry, 245, 845-853 (2017-12-31)
Mushroom extracts contain bioactive compounds potentially useful to functionalize foodstuffs. Herein, alcoholic extracts of Agaricus bisporus were studied for their bioactivity and viability as functional ingredients in a food product with high water content (yogurt). Extracts were microencapsulated (to improve
Isa Gabriela de Medeiros Cavalcante et al.
Experimental gerontology, 66, 10-16 (2015-04-02)
This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. A double blind, randomized, placebo-controlled
Wei Hu et al.
Autophagy, 15(4), 707-725 (2019-01-08)
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. However, the mechanisms
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Anna K Coussens et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(26), 8052-8057 (2015-06-17)
Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1
X T Hu et al.
Cell proliferation, 47(3), 200-210 (2014-03-22)
The important role of cell cycle regulatory molecules in all trans-retinoic acid (ATRA)- and vitamin D3-induced growth inhibition and differentiation induction has been intensively studied in both acute myeloid leukaemia primary cells and a variety of leukaemia cell lines. Cyclin-dependent
Melissa Jensen et al.
Journal of pediatric gastroenterology and nutrition, 61(2), 187-189 (2015-02-05)
Oral high-dose repletion vitamin D therapy, also known as stoss therapy, can be effective in the treatment of nutritional vitamin D deficiency rickets in infants and young children without liver disease and in patients with cystic fibrosis. There is no
A G Fuchs et al.
Journal of helminthology, 88(4), 459-467 (2013-06-08)
Bisphosphonates have been proposed as pharmacological agents against parasite and cancer cell growth. The effect of these compounds on helminthic cell viability and acellular compartment morphology, however, has not yet been studied. The effects of different types of bisphosphonates, namely
Karin Amrein et al.
JAMA, 312(15), 1520-1530 (2014-10-01)
Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It is unknown if this association is causal. To investigate whether a vitamin D3 treatment regimen intended to restore and maintain normal vitamin
Bao-Xin Liu et al.
Medicine, 94(25), e991-e991 (2015-06-25)
Osteoporosis and related fragility fractures represent a serious and global public health problem. To evaluate whether the modified eighth section of Eight-section Brocade (MESE) exercise could improve the symptom and indexes associated with osteoporosis in postmenopausal women. Guangzhou and Liuzhou
G B Ferreira et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 96-101 (2013-11-02)
1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3), and its analogs (i.e. 14,20-bis-epi-19-nor-23-yne-1α,25(OH)2D3 - TX527) have been shown to prevent autoimmunity and prolong islet graft survival in the non-obese diabetic (NOD) mouse. Their effects are mediated by their action on various immune cell types, such
The hormone-like action of 1,25-(OH)2-cholecalciferol (a metabolite of the fat-soluble vitamin D) in the intestine.
A W Norman
Vitamins and hormones, 32, 325-384 (1974-01-01)
Lara Coelho et al.
Nutrition journal, 14, 81-81 (2015-08-19)
HIV infection and antiretroviral therapy (ART) may create unique risk factors for vitamin D insufficiency, including alterations of vitamin D metabolism by ART. We prospectively compared demographic and clinical parameters between vitamin D sufficient and insufficient HIV-infected (HIV+) adults, and
Bassem Refaat et al.
Journal of experimental & clinical cancer research : CR, 34, 71-71 (2015-07-25)
Vitamin D3 and its analogues have recently been shown to enhance the anti-tumour effects of 5- Fluorouracil (5-FU) both in vitro and in xenograft mouse model of colon cancer. This study measured the potential mechanism(s) by which vitamin D3 could
Nicholas A McKeag et al.
JACC. Heart failure, 2(3), 308-317 (2014-06-24)
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number
Jing Zhang et al.
Calcified tissue international, 96(1), 80-87 (2014-11-25)
Thyroid hormones (THs) including thyroxine (T4) and triiodothyronine (T3) play critical roles in bone remodeling. However, the role and mechanism of THs in vascular calcification (VC) have been unclear. To explore the pathophysiological roles of T3 on VC, we investigated
Li-hong Gao et al.
Acta pharmacologica Sinica, 36(9), 1065-1073 (2015-08-19)
To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label
P De Groote et al.
Cell death and differentiation, 22(6), 1012-1024 (2014-11-29)
Receptor-interacting protein kinase 4 (RIPK4)-deficient mice have epidermal defects and fusion of all external orifices. These are similar to Bartsocas-Papas syndrome and popliteal pterygium syndrome (PPS) in humans, for which causative mutations have been documented in the RIPK4 and IRF6
Masahiko Suzuki et al.
The American journal of clinical nutrition, 97(5), 1004-1013 (2013-03-15)
In our previous study, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and the vitamin D receptor (VDR) FokI CC genotype were associated with milder Parkinson disease (PD). We evaluated whether vitamin D3 supplementation inhibits the progression of PD on the basis
Jianfeng Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(3), 1219-1229 (2015-03-15)
Transplantation of bone-marrow derived stem/progenitor cells has an established therapeutic effect on cardiac muscle repair after injury. However, the exact mechanism that underlies this phenomenon is not completely understood. Here we transplanted mesenchymal stem cells (MSCs), a major population from
Valerie Hemmings
The practising midwife, 16(7), 16-17 (2013-08-06)
The National Diet and Nutrition Survey (Bates et al 2011) show adult females have low levels of vitamin D. Many women in midwives' care may be vitamin D deficient. The aim of this article is to update midwives' knowledge of
Michal Stuss et al.
The Journal of clinical endocrinology and metabolism, 98(5), E1007-E1011 (2013-04-02)
Recent research results have confirmed the high significance of the OPG/RANK/RANKL system in the development of bone diseases. The aim of the reported study was to assess gene expression levels of the OPG/RANK/RANKL system in peripheral blood mononuclear cells (PBMCs)
Sarah Nicolai et al.
Science immunology, 5(43) (2020-01-05)
During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and other skin products causes allergic contact dermatitis, a T cell-mediated disease with rising prevalence. Models of αβ T
C Jackson et al.
QJM : monthly journal of the Association of Physicians, 100(4), 185-192 (2007-02-20)
We evaluated the effect of supplementation with vitamin D(3) (excluding the potential effect of calcium supplementation) on the risk of fall and fracture, primarily in postmenopausal women, using a systematic literature review of MEDLINE, EMBASE, BIOSIS and the Cochrane Database
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