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Eva Hoster et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(13), 1338-1346 (2014-04-02)
Mantle-cell lymphoma (MCL) is a distinct B-cell lymphoma associated with poor outcome. In 2008, the MCL International Prognostic Index (MIPI) was developed as the first prognostic stratification tool specifically directed to patients with MCL. External validation was planned to be...
Nayera H K El Sherif et al.
Journal of pediatric hematology/oncology, 36(7), 518-523 (2014-08-12)
Endothelial dysfunction has been reported in children with acute lymphoblastic leukemia (ALL). The aim of this study is to assess Von Willebrand Factor antigen (VWF antigen) and Factor VIII (FVIII) in newly diagnosed ALL patients, in relation to peripheral blast...
Oylum Colpankan Gunes et al.
Journal of biomaterials applications, 35(4-5), 515-531 (2020-07-01)
The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel...
Santa Mandal et al.
Inhalation toxicology, 32(7), 299-310 (2020-07-01)
To explore the therapeutic role of a single dose combination of montelukast (MON) and dexamethasone (DXM) through intra-peritoneal route against paraquat (PQ)-intoxicated experimental Wistar rats. In vivo the survival rate was investigated following the administration of both MON and DXM...
Susan Lightman et al.
Investigative ophthalmology & visual science, 54(7), 4864-4870 (2013-06-14)
To evaluate the effect of a single treatment with dexamethasone intravitreal implant (DEX implant) on patient-reported visual functioning in patients with noninfectious intermediate or posterior uveitis. Patient eyes with noninfectious intermediate or posterior uveitis were randomized to a single treatment...
N H Waldron et al.
British journal of anaesthesia, 110(2), 191-200 (2012-12-12)
The analgesic efficacy and adverse effects of a single perioperative dose of dexamethasone are unclear. We performed a systematic review to evaluate the impact of a single i.v. dose of dexamethasone on postoperative pain and explore adverse events associated with...
Grant E Keeney et al.
Pediatrics, 133(3), 493-499 (2014-02-12)
Dexamethasone has been proposed as an equivalent therapy to prednisone/prednisolone for acute asthma exacerbations in pediatric patients. Although multiple small trials exist, clear consensus data are lacking. This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone...
Anita van den Heuvel et al.
Human molecular genetics, 28(7), 1064-1075 (2018-11-18)
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by sporadic de-repression of the transcription factor DUX4 in skeletal muscle. DUX4 activates a cascade of muscle disrupting events, eventually leading to muscle atrophy and apoptosis. Yet, how sporadic DUX4 expression leads to the...
Ellen C Dengler et al.
Journal of neuroinflammation, 11, 92-92 (2014-06-03)
Peri-spinal subarachnoid (intrathecal; i.t.) injection of non-viral naked plasmid DNA encoding the anti-inflammatory cytokine, IL-10 (pDNA-IL-10) suppresses chronic neuropathic pain in animal models. However, two sequential i.t. pDNA injections are required within a discrete 5 to 72-hour period for prolonged...
Sa Luo et al.
Toxicology letters, 229(1), 85-92 (2014-06-10)
Various therapeutic regimes have been proposed with limited success for treatment of phosgene-induced acute lung injury (P-ALI). Corticoids were shown to be efficacious against chlorine-induced lung injury but there is still controversy whether this applies also to P-ALI. This study...
Intravenous or perineural dexamethasone for interscalene brachial plexus block: the equivalence not yet proven.
R V Sondekoppam et al.
British journal of anaesthesia, 112(1), 175-176 (2013-12-10)
Sapna Oberoi et al.
Pediatric blood & cancer, 61(12), 2218-2222 (2014-09-02)
Medication errors occur universally. Inappropriate administration of chemotherapy drugs can have adverse effects in cancer patients. Our objective was to assess the rate and type of medication errors in children with acute lymphoblastic leukemia (ALL) receiving oral chemotherapy in outpatient...
Kazuki Takeishi et al.
Cell reports, 31(9), 107711-107711 (2020-06-04)
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods...
Kelly S Harrison et al.
Journal of virology, 93(13) (2019-04-12)
Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of...
Sara Bringhen et al.
Blood, 124(1), 63-69 (2014-05-24)
This multicenter, open-label phase 2 trial determined the safety and efficacy of carfilzomib, a novel and irreversible proteasome inhibitor, in combination with cyclophosphamide and dexamethasone (CCyd) in patients with newly diagnosed multiple myeloma (NDMM) ≥65 years of age or who...
Adrija Kalvisa et al.
PLoS biology, 16(12), e2006249-e2006249 (2018-12-12)
Hepatic circadian gene transcription is tightly coupled to feeding behavior, which has a profound impact on metabolic disorders associated with diet-induced obesity. Here, we describe a genomics approach to uncover mechanisms controlling hepatic postprandial gene expression. Combined transcriptomic and cistromic...
J R Bellis et al.
British journal of anaesthesia, 113(1), 23-42 (2014-06-20)
Summary In children undergoing tonsillectomy, dexamethasone is recommended to reduce the risk of postoperative nausea and vomiting while non-steroidal anti-inflammatory drugs (NSAIDs) are used for pain relief. We aimed to determine whether children who receive dexamethasone or dexamethasone with NSAID...
Mark C Gillies et al.
Ophthalmology, 121(12), 2473-2481 (2014-08-27)
To report the 12-month results of the first head-to-head comparison of a dexamethasone implant (Ozurdex; Allergan, Inc., Irvine, CA) versus bevacizumab (Avastin; Genentech, South San Francisco, CA) for center-involving diabetic macular edema (DME). Phase 2, prospective, multicenter, randomized, single-masked clinical...
Michael Garofalo et al.
Health physics, 106(1), 56-72 (2013-11-28)
Several radiation dose- and time-dependent tissue sequelae develop following acute high-dose radiation exposure. One of the recognized delayed effects of such exposures is lung injury, characterized by respiratory failure as a result of pneumonitis that may subsequently develop into lung...
Qiong Fan et al.
Cells, 9(5) (2020-05-18)
The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid metabolism in the liver. More knowledge of their mechanistic interplay is needed to understand...
Wanderley Marques Bernardo et al.
Revista da Associacao Medica Brasileira (1992), 59(4), 387-391 (2013-07-23)
To verify the efficacy of dexamethasone in the prophylaxis of nausea and vomiting in patients submitted to laparoscopic cholecystectomy. This was a systematic review of the literature through the MEDLINE, Embase, and LILACS databases. Only controlled and randomized clinical trials...
Jeffery B Ostler et al.
Journal of virology, 95(4) (2020-11-20)
Following acute infection, herpes simplex virus 1 (HSV-1) lytic cycle viral gene expression is silenced; consequently, lifelong latency in neurons is established. Certain external stimuli that trigger reactivation from latency also activate the glucocorticoid receptor (GR). The synthetic corticosteroid dexamethasone...
[New and old medications for croup and seizures in children. Oral dexamethasone and buccal midazolam may provide better treatment].
Axelsson Inge et al.
Lakartidningen, 110(48), 2163-2163 (2014-01-18)
Shankar Swaminathan et al.
Journal of biomedical nanotechnology, 9(6), 998-1007 (2013-07-19)
Nanosponges (NS) were synthesized by crosslinking of beta cyclodextrins with diphenyl carbonate. It is a hyper-branched polymer with an ultra high encapsulation efficiency leading to formation of colloidal systems. Dexamethasone (DEX) on the other hand is a poorly soluble drug...
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone...
Ning-Ai Liu et al.
Molecular endocrinology (Baltimore, Md.), 17(5), 959-966 (2003-02-11)
We characterized zebrafish proopiomelanocortin (POMC) gene promoter, and sequence analysis revealed that the promoter contains regulatory elements conserved among vertebrate species. To monitor the ontogeny of the pituitary POMC lineage in living vertebrates, we generated transgenic zebrafish expressing green fluorescent...
Rocío Fuentes-Mateos et al.
Cell death & disease, 10(11), 838-838 (2019-11-07)
We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains...
D Fagot et al.
International journal of cosmetic science, 40(4), 388-400 (2018-06-13)
Oxidative stress and low-grade chronic inflammation stand out as key features of physiological skin ageing. The aim of this study was to examine in normal human epidermal keratinocytes (NHEK) and human dermal fibroblasts (HDF) grown in vitro, the antioxidant and...
D Rendina et al.
Minerva endocrinologica, 38(2), 211-215 (2013-06-05)
Multiple symmetric lipomatosis (MSL, OMIM 151800), is a rare disease characterised by the growth of uncapsulated masses of abnormal adipose tissue around the neck, shoulders or other parts of the trunk and typically associated with high ethanol intake. We describe...
M T Winkler et al.
Journal of virology, 74(11), 5337-5346 (2000-05-09)
Bovine herpesvirus 1 (BHV-1), like other members of the Alphaherpesvirinae subfamily, establishes latent infection in sensory neurons. Reactivation from latency can occur after natural or corticosteroid-induced stress culminating in recurrent disease and/or virus transmission to uninfected animals. Our previous results...
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