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Showing 1-30 of 173 results for "D3404" within Papers
Yongqiang Yang et al.
Journal of nanoscience and nanotechnology, 13(7), 4521-4538 (2013-08-02)
Much tremendous break through have been obtained in recent years for nanopore sequencing to achieve the goal of $1000 genome. As a method of single molecule sequencing, nanopore sequencing can discriminate the individual molecules of the target DNA strand rapidly
Human evolution. Neandertals and moderns made imperfect mates.
Ann Gibbons
Science (New York, N.Y.), 343(6170), 471-472 (2014-02-01)
Vitaly Epshtein et al.
Nature, 505(7483), 372-377 (2014-01-10)
UvrD helicase is required for nucleotide excision repair, although its role in this process is not well defined. Here we show that Escherichia coli UvrD binds RNA polymerase during transcription elongation and, using its helicase/translocase activity, forces RNA polymerase to
Noninvasive prenatal cell-free fetal DNA-based screening for aneuploidies other than trisomy 21.
Technology Evaluation Center Assessment Program. Executive summary, 29(7), 1-7 (2015-01-13)
Hao Yin et al.
Nature reviews. Genetics, 15(8), 541-555 (2014-07-16)
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat pathological conditions. This modulation is accomplished by introducing exogenous nucleic acids such as DNA, mRNA, small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides. Given the
Sebastian Pott et al.
Nature genetics, 47(1), 8-12 (2014-12-31)
The term 'super-enhancer' has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin immunoprecipitation and sequencing (ChIP-seq). Here we review the identification and composition of super-enhancers
Xianhui An et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(10), 1111-1116 (2014-01-15)
DNA phosphorothioate modification means substituting a non-bridging oxygen with a sulfur in DNA. The modification endows DNA with such chemical property that protects the hosting bacteria against peroxide. The modification is controlled by a dnd gene cluster. Salmonella entericaserovar Cerro
M Gregori et al.
Diseases of aquatic organisms, 105(1), 9-20 (2013-07-10)
In the mesozooplanktonic community of the coastal upwelling system of the Ría de Vigo (NW Spain), the euphausiid Nyctiphanes couchii has been identified for the first time in temperate waters of the NE Atlantic as the intermediate host for cystacanths
Antonio Villalba et al.
Diseases of aquatic organisms, 109(1), 55-80 (2014-05-02)
The highest shellfishery catch in Galicia (NW Spain) has traditionally been cockle Cerastoderma edule. The shellfish bed located in Lombos do Ulla (Ría de Arousa) used to be among those with the highest cockle production; however, cockle mortality rate increased
Ravit Agassi et al.
American journal of clinical pathology, 143(1), 18-24 (2014-12-17)
To evaluate circulating cell-free DNA (CFD) measured by a simple fluorescent assay as a biomarker of breast cancer. We enrolled 38 patients with breast cancer before surgery, two patients with noncancerous breast lesions, nine patients after surgery, 16 healthy participants
Biomolecules. The dark side of sunlight and melanoma.
John-Stephen Taylor
Science (New York, N.Y.), 347(6224), 824-824 (2015-02-24)
Han Na Noh et al.
Journal of nanoscience and nanotechnology, 13(8), 5240-5244 (2013-07-26)
Recently quantum dots (QDs) have been extensively used in the field of biotechnology. QDs have merits of wide selection of emission wavelength and exceptional stability against photo bleaching over conventional organic fluorophores and are used in cell imaging, biomarker, and
Dan Jiang et al.
Investigative ophthalmology & visual science, 56(1), 339-345 (2014-12-20)
To evaluate variants in the LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 genes in 298 unrelated patients with early-onset high myopia (eoHM). Genomic DNA from 298 patients with eoHM was analyzed by whole exome sequencing. Variants in LRPAP1, CTSH, LEPREL1
Chengzu Long et al.
Science (New York, N.Y.), 345(6201), 1184-1188 (2014-08-16)
Duchenne muscular dystrophy (DMD) is an inherited X-linked disease caused by mutations in the gene encoding dystrophin, a protein required for muscle fiber integrity. DMD is characterized by progressive muscle weakness and a shortened life span, and there is no
Giang Huong Nguyen et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9905-9910 (2014-06-25)
Bloom syndrome is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition, and caused by mutations in the gene encoding the Bloom syndrome, RecQ helicase-like (BLM) protein. To determine whether altered gene expression might be responsible for
Florence F Roussotte et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(19), 6537-6545 (2014-05-09)
The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent genome-wide association study of LOAD found the strongest evidence of association with CLU
Linus Girdland Flink et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6184-6189 (2014-04-23)
Modern domestic plants and animals are subject to human-driven selection for desired phenotypic traits and behavior. Large-scale genetic studies of modern domestic populations and their wild relatives have revealed not only the genetic mechanisms underlying specific phenotypic traits, but also
Nanoparticle self-assembly: Bonding them all.
Ulrich Simon
Nature materials, 12(8), 694-696 (2013-07-24)
L Zhang et al.
European review for medical and pharmacological sciences, 17(14), 1874-1880 (2013-07-24)
Circadian rhythms tend to change as animals age; however, the molecular mechanisms underlying these are not yet fully understood. To investigate whether the DNA methylation of clock genes changes with age and contributes to circadian dysfunction in aged animals. We
Ming Zeng et al.
Science (New York, N.Y.), 346(6216), 1486-1492 (2014-12-20)
Multivalent molecules with repetitive structures including bacterial capsular polysaccharides and viral capsids elicit antibody responses through B cell receptor (BCR) crosslinking in the absence of T cell help. We report that immunization with these T cell-independent type 2 (TI-2) antigens
J Zeyland et al.
Polish journal of veterinary sciences, 16(2), 265-273 (2013-08-27)
Extinct aurochs (Bos primigenius), accepted as the ancestor of domestic cattle, was one of the largest wild animals inhabiting Europe, Asia and North Africa. The gradual process of aurochs extinction finished in Poland in 1627, were the last recorded aurochs
Ching-Yu Cheng et al.
Investigative ophthalmology & visual science, 56(1), 478-483 (2014-12-30)
Recently the common SIX6 missense variant rs33912345 was found to be highly associated with glaucoma. The aim of this study was to investigate the association between this SIX6 variant and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain
Sanjay Premi et al.
Science (New York, N.Y.), 347(6224), 842-847 (2015-02-24)
Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine. We found that in melanocytes, CPDs are generated for >3 hours after
Sriram Kosuri et al.
Nature methods, 11(5), 499-507 (2014-05-02)
For over 60 years, the synthetic production of new DNA sequences has helped researchers understand and engineer biology. Here we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on recent technologies that allow for
Scott O Sundberg et al.
Clinical chemistry, 60(10), 1306-1313 (2014-08-15)
Clinical molecular testing typically batches samples to minimize costs or uses multiplex lab-on-a-chip disposables to analyze a few targets. In genetics, multiple variants need to be analyzed, and different work flows that rapidly analyze multiple loci in a few targets
Xin Cai et al.
Molecular cell, 54(2), 289-296 (2014-04-29)
The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic acids represent a major class of pathogen signatures that can trigger robust immune responses. The presence of DNA in the cytoplasm of mammalian cells is
Zhi-Hua Li et al.
Ecotoxicology and environmental safety, 109, 10-14 (2014-08-19)
The effect of long-term exposure to tributyltin (TBT) on the intestine-related biochemical biomarkers in common carp was investigated in this study. Fish were exposed at sub-lethal concentrations of TBT (75 ng/L, 0.75 and 7.5 μg/L) for 60 days. Multiple biomarkers
Kieren J Mitchell et al.
Science (New York, N.Y.), 344(6186), 898-900 (2014-05-24)
The evolution of the ratite birds has been widely attributed to vicariant speciation, driven by the Cretaceous breakup of the supercontinent Gondwana. The early isolation of Africa and Madagascar implies that the ostrich and extinct Madagascan elephant birds (Aepyornithidae) should
Look Ma, no PCNA: how DNA polymerase ε synthesizes long stretches of DNA without a processivity factor.
Karl E Zahn et al.
Nature structural & molecular biology, 21(1), 12-14 (2014-01-07)
James Watson: thinking outside the genome.
Geoff Watts
Lancet (London, England), 383(9919), 775-775 (2014-03-04)
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