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Peng Wang et al.
Chemical research in toxicology, 28(6), 1224-1233 (2015-05-09)
Sulfur mustard (SM) is a powerful alkylating vesicant that can rapidly penetrate skin, ocular, and lung bronchus mucous membranes and react with numerous nucleophiles in vivo. Although the lesion mechanisms of SM remain unclear, DNA damage is believed to be...
Jenni Küblbeck et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19)
Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug...
Jonathan Lerner et al.
Molecular cell, 79(4), 677-688 (2020-06-24)
Enzymatic probes of chromatin structure reveal accessible versus inaccessible chromatin states, while super-resolution microscopy reveals a continuum of chromatin compaction states. Characterizing histone H2B movements by single-molecule tracking (SMT), we resolved chromatin domains ranging from low to high mobility and...
A Priyanka et al.
Free radical research, 48(10), 1206-1217 (2014-07-22)
Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-signalling pathway is expected to...
Arjunan Subramanian et al.
PloS one, 10(6), e0127992-e0127992 (2015-06-11)
The human umbilical cord (UC) is an attractive source of mesenchymal stem cells (MSCs) with unique advantages over other MSC sources. They have been isolated from different compartments of the UC but there has been no rigorous comparison to identify...
Peng Li et al.
Experimental and therapeutic medicine, 21(4), 336-336 (2021-03-19)
Osteoporosis is a common complication of long-term use of glucocorticoids (GCs) characterized by the loss of bone mass and damage of the microarchitecture as well as osteoblast dysfunction. Previous studies have demonstrated that microRNA-22 (miR-22) is the negative modulator of...
Zhang Tianzhu et al.
Inflammation, 38(3), 1036-1043 (2014-11-25)
The aim of the current study was to use a mouse model of allergic asthma to investigate whether cordycepin has antiasthmatic effects, and if so, to determine the mechanism of these effects. A total of 50 mice were randomly assigned...
Alfred G Tamayo et al.
FEBS open bio, 10(9), 1868-1879 (2020-07-28)
Transcriptional dynamics of cancer cells govern cell fate decisions and are therapeutically actionable drug targets. In this study, we engineered a circulating cancer cell line that secretes a luciferase reporter to capture constitutive and circadian clock-driven transcription dynamics over the...
Yong Zhang et al.
Lipids in health and disease, 10, 122-122 (2011-07-27)
Hepatic inflammation and degeneration induced by lipid depositions may be the major cause of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of saturated and unsaturated fatty acids (FA) on apoptosis in primary rat hepatocytes. The...
Eva Hoster et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(13), 1338-1346 (2014-04-02)
Mantle-cell lymphoma (MCL) is a distinct B-cell lymphoma associated with poor outcome. In 2008, the MCL International Prognostic Index (MIPI) was developed as the first prognostic stratification tool specifically directed to patients with MCL. External validation was planned to be...
Maurizio Aquino et al.
Bioorganic & medicinal chemistry, 16(19), 9056-9064 (2008-09-16)
Petrosaspongiolide M (PM), a marine sesterterpene metabolite bearing the gamma-hydroxybutenolide scaffold and displaying a potent inhibitory activity toward PLA(2) enzyme, was selected by us as an attractive target in order to explore its mechanism of action at molecular level. In...
Tiina Petäistö et al.
The Journal of physiology, 598(16), 3373-3393 (2020-05-26)
Extracellular matrix is highly remodelled in obesity and associates with the development of metabolic disorders, such as insulin resistance. Previously, we have shown that the lack of specific collagen XVIII isoforms impairs adipocyte differentiation in mice. Here, we show that...
Chadia L Robertson et al.
The Journal of biological chemistry, 290(29), 18227-18236 (2015-06-14)
Astrocyte elevated gene-1 (AEG-1), also known as MTDH (metadherin) or LYRIC, is an established oncogene. However, the physiological function of AEG-1 is not known. To address this question, we generated an AEG-1 knock-out mouse (AEG-1KO) and characterized it. Although AEG-1KO...
Jiejing Li et al.
Scientific reports, 9(1), 11191-11191 (2019-08-03)
During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differentiates into many types of cells. The transcription factor Snai2, which is induced by canonical Wnt signaling to be expressed in the...
Nayera H K El Sherif et al.
Journal of pediatric hematology/oncology, 36(7), 518-523 (2014-08-12)
Endothelial dysfunction has been reported in children with acute lymphoblastic leukemia (ALL). The aim of this study is to assess Von Willebrand Factor antigen (VWF antigen) and Factor VIII (FVIII) in newly diagnosed ALL patients, in relation to peripheral blast...
Yu-Hua Chao et al.
PloS one, 9(10), e110338-e110338 (2014-10-23)
Sepsis remains an important cause of death worldwide, and vigorous immune responses during sepsis could be beneficial for bacterial clearance but at the price of collateral damage to self tissues. Mesenchymal stem cells (MSCs) have been found to modulate the...
F C Bach et al.
European cells & materials, 30, 132-146 (2015-09-22)
During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). NCs secrete factors with regenerative potential, making them an interesting focus for regenerative treatments. During initial development, these strategies preferably employ non-human...
Iris L Kim et al.
Tissue engineering. Part A, 21(21-22), 2680-2690 (2015-09-25)
Current clinically approved methods for cartilage repair are generally based on either endogenous cell recruitment (e.g., microfracture) or chondrocyte delivery (e.g., autologous chondrocyte implantation). However, both methods culminate in repair tissue with inferior mechanical properties and the addition of biomaterials...
Kwang-Pyo Lee et al.
Genes & development, 29(15), 1605-1617 (2015-07-29)
The myogenic capacity of myoblasts decreases in skeletal muscle with age. In addition to environmental factors, intrinsic factors are important for maintaining the regenerative potential of muscle progenitor cells, but their identities are largely unknown. Here, comparative analysis of microRNA...
Sandra Sekelj et al.
Current eye research, 40(4), 407-414 (2014-06-10)
To evaluate whether the vascular endothelial growth factor A (VEGF-A) in the recipient cornea measured at the time of penetrating keratoplasty (PK) can act as a prognostic factor for corneal graft reaction development. The study included 25 eyes (of 25...
Yoshihisa Matsumoto et al.
Stem cells (Dayton, Ohio), 33(6), 1730-1742 (2015-03-17)
Successful in vitro disease-recapitulation using patient-specific induced pluripotent stem cells (iPSCs) requires two fundamental technical issues: appropriate control cells and robust differentiation protocols. To investigate fibrodysplasia ossificans progressiva (FOP), a rare genetic disease leading to extraskeletal bone formation through endochondral...
Begoña Euba et al.
Antimicrobial agents and chemotherapy, 59(5), 2700-2712 (2015-02-26)
Nontypeable Haemophilus influenzae (NTHI) is an opportunistic pathogen that is an important cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD is an inflammatory disease of the airways, and exacerbations are acute inflammatory events superimposed on this background...
Susan Lightman et al.
Investigative ophthalmology & visual science, 54(7), 4864-4870 (2013-06-14)
To evaluate the effect of a single treatment with dexamethasone intravitreal implant (DEX implant) on patient-reported visual functioning in patients with noninfectious intermediate or posterior uveitis. Patient eyes with noninfectious intermediate or posterior uveitis were randomized to a single treatment...
Masako Naito et al.
Molecular and cellular endocrinology, 417, 114-123 (2015-10-01)
Glucocorticoids (GCs) affect the proliferation of growth plate chondrocytes. In this study, we investigated the role of the GC-inducible promyelocytic leukemia zinc finger (PLZF) gene in chondrocyte differentiation by using the chondrogenic cell line ATDC5. PLZF overexpression suppressed cell cycle...
Min Sung Park et al.
Cell transplantation, 24(6), 1067-1083 (2014-04-25)
Bone marrow-derived mesenchymal stem cells (BMSCs) are a good cell source for regeneration of cartilage as they can migrate directly to the site of cartilage injury and differentiate into articular chondrocytes. Articular cartilage defects do not heal completely due to...
Ying Zhang et al.
Biomaterials, 64, 88-97 (2015-07-01)
Autologous stem cells are a promising cell source for cartilage regeneration; however, cell replicative senescence and joint posttraumatic inflammation provide challenges in bringing this treatment modality to fruition. In this study, we hypothesized that preconditioning with p38 MAPK inhibitor (sb203580)...
Yonghan He et al.
PloS one, 9(10), e110711-e110711 (2014-10-21)
Ursolic acid (UA), a triterpenoid compound, is reported to have a glucose-lowering effect. However, the mechanisms are not fully understood. Adipose tissue is one of peripheral tissues that collectively control the circulating glucose levels. The objective of the present study...
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair.
Okuchi, et al.
Nature Materials, 20, 108-118 (2021)
Liuqiang Zhang et al.
Bioorganic & medicinal chemistry, 19(16), 4882-4886 (2011-07-22)
Harpagide (1) and harpagoside (2) are two iridoid glycosides existing in many medicinal plants. Although they are believed to be the main bioactive compounds related to the anti-inflammatory efficacy of these plants, the mechanisms of their anti-inflammatory activities remain unclear....
Monique J LeMieux et al.
The Journal of nutrition, 145(3), 411-417 (2015-03-04)
Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, inflammation, and thrombosis. Research to develop nutritional interventions to prevent or treat obesity and its associated diseases is greatly needed. Previously, we demonstrated the...
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