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Qi Li et al.
Reproduction (Cambridge, England), 160(4), 511-519 (2020-07-23)
Endometriosis (EMs) is an estrogen (E2)-dependent inflammatory disorder. Although EMs is considered a benign disease, it presents with malignant characteristics, such as migration and invasion. An increasing number of studies have shown that aberrantly expressed circular RNAs (circRNAs) play an...
Takamitsu Onitsuka et al.
Anticancer research, 31(3), 855-860 (2011-04-19)
Positive expression of estrogen receptor (ER) beta is correlated with a favorable prognosis for patients with epidermal growth factor receptor (EGFR) mutations and predicts a good clinical outcome for patients with lung cancer after treatment with an EGFR-tyrosine kinase inhibitor...
Gonadal steroids and body composition, strength, and sexual function in men.
Joel S Finkelstein et al.
The New England journal of medicine, 369(25), 2457-2457 (2013-12-20)
Shoudong Guo et al.
Biochimica et biophysica acta, 1841(6), 836-846 (2014-03-08)
Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 108 healthy participants were...
Raul Zavaliev et al.
Cell, 182(5), 1093-1108 (2020-08-19)
In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict cell death remain unclear....
Baojian Xue et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H191-H198 (2014-05-27)
This study investigated sex differences in the sensitization of angiotensin (ANG) II-induced hypertension and the role of central estrogen and ANG-(1-7) in this process. Male and female rats were implanted for telemetered blood pressure (BP) recording. A subcutaneous subpressor dose...
Abbie S Ireland et al.
Cancer cell, 38(1), 60-78 (2020-06-01)
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based on expression of ASCL1, NEUROD1, POU2F3, or YAP1. Here, we use mouse and human...
Thomas Wiglenda et al.
Journal of medicinal chemistry, 48(20), 6516-6521 (2005-09-30)
The 1H-imidazoles 7a-e were synthesized and tested for biological activity in vitro. The results pointed to a clear structure-activity relationship. The introduction of an ethyl chain at C5 of the 1,2,4-tris(4-hydroxyphenyl)-1H-imidazole 7a caused hormonal activity in estrogen receptor positive MCF-7-2a...
Qinghai Meng et al.
Biochemical pharmacology, 180, 114134-114134 (2020-07-07)
Decreases in estrogen secretion and estrogen receptor function lead to an increase in the incidence of dyslipidemia and cardiovascular disease (CVD) in postmenopausal women. We previously reported that β-estradiol has a significant regulatory effect on lipids in ApoE-/- mice with...
Lin Zhang et al.
Frontiers in cardiovascular medicine, 8, 679240-679240 (2021-07-06)
The incidence of dysfunctional vasomotor diseases has mostly occurred in postmenopausal women but not in premenopausal women. Hence, this study sought to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function. Also, attempts were made to utilize...
Estradiol synthesis and release in cultured female rat bone marrow stem cells
Zhang D, et al.
BioMed Research International, 2013 (2013)
Maria Halabalaki et al.
Journal of natural products, 71(11), 1934-1937 (2008-11-07)
Phytochemical investigation of a methanol extract of Onobrychis ebenoides yielded five new 3-formyl-2-arylbenzofurans, namely, ebenfurans IV-VIII (1-5), together with the known compounds ebenfurans I, II (6), and III (7). Only 1 and 7 exhibited growth inhibitory activity against MCF-7 and...
Lee P Shulman
The journal of family planning and reproductive health care, 39(3), 211-216 (2013-05-28)
Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply the 21 days of combination hormonal tablets. These regimens were developed to ensure...
On estrogen, cholesterol metabolism, and breast cancer.
Margaret Warner et al.
The New England journal of medicine, 370(6), 572-573 (2014-02-07)
Pin-Yao Huang et al.
Journal of experimental botany, 70(3), 1033-1047 (2018-11-22)
Recognition of microbe-associated molecular patterns (MAMPs) derived from invading pathogens by plant pattern recognition receptors (PRRs) initiates a subset of defense responses known as pattern-triggered immunity (PTI). Transcription factors (TFs) orchestrate the onset of PTI through complex signaling networks. Here...
Laura Ballester et al.
Fertility and sterility, 102(6), 1762-1768 (2014-09-23)
To determine optimal conditions for the inclusion of oviductal fluid (OF) in IVF protocols. Experimental prospective study. Mammalian reproduction research laboratory. Oviducts and ovaries from porcine females were collected at a slaughterhouse. A total of 30 oviducts and 1,285 oocytes...
Senlin Xiao et al.
Molecular plant, 13(9), 1270-1283 (2020-07-07)
Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility (CMS). Using yeast one-hybrid screening, we identified a transcription factor, ZmDREB1.7, that is highly expressed in sterile microspores at the large vacuole stage...
Disha Jain et al.
Bioorganic & medicinal chemistry letters, 20(17), 5258-5261 (2010-07-28)
Estrogen receptors (ERs) regulate gene transcription through classic estrogen response elements (EREs) as well as AP-1 responsive genes. The common SERMs Raloxifene, Tamoxifen, and ICI164384 function as ER antagonists on EREs but as ERbeta agonists/partial agonists on AP-1 responsive genes....
Dominik Brokatzky et al.
Infection and immunity, 88(6) (2020-03-18)
Apoptotic cell death can be an efficient defense reaction of mammalian cells infected with obligate intracellular pathogens; the host cell dies and the pathogen cannot replicate. While this is well established for viruses, there is little experimental support for such...
Estrogens and myocardial chymase: new insights into pathological hypertrophy and remodeling.
Jorge E Jalil et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 271-272 (2014-11-19)
Karen A Dunphy et al.
Journal of mammary gland biology and neoplasia, 25(1), 51-68 (2020-03-11)
Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as rodent models...
Valentino Martina et al.
Clinical endocrinology, 64(3), 260-264 (2006-02-21)
Several clinical and population-based studies suggest that dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) play a protective role against atherosclerosis and coronary artery disease in human. However, the mechanisms underlying this action are still unknown. It has recently been suggested that...
Aniruddha Das et al.
Archives of sexual behavior, 43(7), 1403-1415 (2014-03-07)
Using nationally representative data from the 2005-2006 U.S. National Social Life, Health, and Aging Project, this study queried relationship, sexual, and sex hormone patterns among married evangelical women and men aged 57-85, relative to those in other religions. Results suggested...
Dan Tong et al.
Biology of reproduction, 80(6), 1099-1106 (2009-01-30)
Expression of GJA1 (commonly known as connexin43 or Cx43), a major myometrial gap junction protein, is upregulated before the onset of delivery, suggesting an essential role for Cx43-mediated gap junctional intercellular communication (GJIC) in normal uterine contraction during parturition. To...
Christine Cadot et al.
Bioorganic & medicinal chemistry, 15(2), 714-726 (2006-11-18)
A series of estrone and estradiol derivatives having an N-butyl,methyl heptanamide side chain at C6-position were synthesized, tested as inhibitors of type 1 17beta-HSD and assessed for their possible estrogenic activity. A better type 1 17beta-HSD inhibition was obtained for...
Mariana Nigro et al.
Endocrinology, 155(8), 2881-2891 (2014-06-11)
Menopause is associated with increased visceral adiposity and disrupted glucose homeostasis, but the underlying molecular mechanisms related to these metabolic changes are still elusive. Brown adipose tissue (BAT) plays a key role in energy expenditure that may be regulated by...
Giang T Nguyen et al.
iScience, 24(8), 102871-102871 (2021-08-14)
Signaling cascades converting the recognition of pathogens to efficient inflammatory responses by neutrophils are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) generation following neutrophil stimulation by integrins, formyl peptide receptors, and for...
Kunling Teng et al.
PloS one, 5(6), e11280-e11280 (2010-06-30)
Beet severe curly top virus (BSCTV) is a leafhopper transmitted geminivirus with a monopartite genome. C4 proteins encoded by geminivirus play an important role in virus/plant interaction. To understand the function of C4 encoded by BSCTV, two BSCTV mutants were...
Alexander E Davies et al.
Cell systems, 11(2), 161-175 (2020-07-30)
Intratumoral heterogeneity is associated with aggressive tumor behavior, therapy resistance, and poor patient outcomes. Such heterogeneity is thought to be dynamic, shifting over periods of minutes to hours in response to signaling inputs from the tumor microenvironment. However, models of...
Lianguo Chen et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 116-125 (2014-03-04)
This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingredient used in the commercial antifoulant SeaNine 211, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) was employed as...
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