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Kazuto Taniguchi et al.
Diabetologia, 58(9), 2056-2063 (2015-06-10)
In humans, the rate of beta cell proliferation declines rapidly during the postnatal period and remains low throughout adult life. Recent studies suggest that this may reflect the distribution of cell cycle regulators which, unusually, are located in the cytosolic...
Robert W Holdcraft et al.
Cell transplantation, 23(8), 929-944 (2013-05-03)
The transplantation of porcine islets of Langerhans to treat type 1 diabetes may provide a solution to the demand for insulin-producing cells. Porcine islets encapsulated in agarose-agarose macrobeads have been shown to function in nonimmunosuppressed xenogeneic models of both streptozotocin-induced...
Patricia de Godoy Bueno et al.
PloS one, 10(4), e0124369-e0124369 (2015-04-30)
The purpose of this study was to investigate the effects of multiple infusions of allogeneic MSCs on glucose homeostasis and morphometry of pancreatic islets in high- fat diet (HFD) fed mice. Swiss mice were fed standard diet (C group) or...
Eva Ludvigsen et al.
Upsala journal of medical sciences, 120(3), 157-168 (2015-05-01)
Somatostatin acts through five receptor subtypes (SSTRs 1-5). We aimed to investigate SSTRs mRNA expression and protein distribution in whole rat embryos, with special emphasis on the pancreas. Rat embryos were collected on embryonal days 10, 11, 12, 14, 15...
Danielle L Gomez et al.
PloS one, 10(8), e0133862-e0133862 (2015-08-20)
Neurogenin 3 (NGN3) is necessary and sufficient for endocrine differentiation during pancreatic development and is expressed by a population of progenitor cells that give rise exclusively to hormone-secreting cells within islets. NGN3 protein can be detected in the adult rodent...
Yingxu Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14863-14877 (2020-09-13)
Appropriate control of hepatic gluconeogenesis is essential for the organismal survival upon prolonged fasting and maintaining systemic homeostasis under metabolic stress. Here, we show protein arginine methyltransferase 1 (PRMT1), a key enzyme that catalyzes the protein arginine methylation process, particularly...
Kanako Tamura et al.
PloS one, 10(5), e0126003-e0126003 (2015-05-06)
Glucagon-like peptide-1 (GLP-1) receptor agonists potentiate glucose-induced insulin secretion. In addition, they have been reported to increase pancreatic beta cell mass in diabetic rodents. However, the precise mode of action of GLP-1 receptor agonists still needs to be elucidated. Here...
Lili Ren et al.
Cells, tissues, organs, 199(5-6), 329-341 (2014-12-05)
Human adipose tissue-derived stem cells (hASCs) are considered an ideal tool for the supply of insulin-producing cells to treat diabetes mellitus, with high differentiation efficiency. Islet neogenesis-associated protein (INGAP) is an initiator of islet neogenesis, and the peptide sequence comprising...
Jiaxi Chen et al.
Diabetologia, 58(5), 1036-1044 (2015-02-28)
ANGPTL8 is a circulatory hormone secreted from liver and adipose tissue that promotes pancreatic beta cell proliferation and interferes with triacylglycerol metabolism in mice. The clinical significance of its effects on inducing beta cell proliferation is limited because it causes...
Dan-Dan Yin et al.
World journal of gastroenterology, 20(22), 6884-6896 (2014-06-20)
To investigate the effect of mesothelin in the remodeling of the endocrine pancreas in neonatal rats. Overexpression or downregulation of mesothelin expression in INS-1 cells was carried out to investigate the effect of mesothelin during cell proliferation and cell apoptosis...
S T Glenn et al.
Oncogene, 33(50), 5706-5715 (2013-12-03)
Efforts to model human pancreatic neuroendocrine tumors (PanNETs) in animals have been moderately successful, with minimal evidence for glucagonomas or metastatic spread. The renin gene, although classically associated with expression in the kidney, is also expressed in many other extrarenal...
Teresa L Mastracci et al.
Scientific reports, 5, 13269-13269 (2015-08-25)
The pancreas, in most studied vertebrates, is a compound organ with both exocrine and endocrine functions. The exocrine compartment makes and secretes digestive enzymes, while the endocrine compartment, organized into islets of Langerhans, produces hormones that regulate blood glucose. High...
Aliye Uc et al.
Clinical science (London, England : 1979), 128(2), 131-142 (2014-08-22)
Diabetes is a common and significant co-morbidity in cystic fibrosis (CF). The pathogenesis of cystic fibrosis related diabetes (CFRD) is incompletely understood. Because exocrine pancreatic disease is similar between humans and pigs with CF, the CF pig model has the...
Wook Kim et al.
FEBS letters, 588(17), 3233-3239 (2014-07-16)
Pancreatic polypeptide (PP) is a major agonist for neuropeptide Y4 receptors (NPY4R). While NPY4R has been identified in various tissues, the cells on which it is expressed and its function in those cells has not been clearly delineated. Here we...
Shiva Reddy et al.
Diabetologia, 58(5), 1024-1035 (2015-02-18)
The role of peri-islet CD45-positive leucocytes, as one component of insulitis, in beta cell death during human type 1 diabetes remains unclear. We undertook a case study, comparing and quantifying leucocytes in the peri- and intra-islet areas in insulin-positive and...
Yuko Takano et al.
PloS one, 10(7), e0133812-e0133812 (2015-07-21)
Animal models with defective glucagon action show hyperplasia of islet α-cells, however, the regulatory mechanisms underlying the proliferation of islet endocrine cells remain largely to be elucidated. The Gcggfp/gfp mice, which are homozygous for glucagon/green fluorescent protein knock-in allele (GCGKO)...
Lipodystrophy due to adipose tissue-specific insulin receptor knockout results in progressive NAFLD
Softic S, et al.
Diabetes, 65(8), 2187-2200 (2016)
Camille Huet et al.
The Journal of biological chemistry, 295(18), 5836-5849 (2020-03-19)
The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes...
Christopher J Lelliott et al.
PloS one, 9(11), e112109-e112109 (2014-11-27)
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R1c...
Liehua Liu et al.
Biochemical and biophysical research communications, 453(3), 398-404 (2014-10-01)
Dipeptidyl peptidase 4 (DPP-4) was recently found to be expressed in human and mouse islets with different expression patterns. However, whether species-dependent expression pattern is a generalized phenomenon and whether islet DPP-4 activity is regulated are not known. This study...
Fai Yiu Siu et al.
Nature, 499(7459), 444-449 (2013-07-19)
Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of glucose from the liver during fasting; thus GCGR plays an important role in glucose homeostasis. Here we report the crystal structure of the seven transmembrane helical...
Lindsey C Morris et al.
Journal of biomolecular screening, 19(6), 847-858 (2014-02-15)
Injectable, degradation-resistant peptide agonists for the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R), such as exenatide and liraglutide, activate the GLP-1R via a complex orthosteric-binding site and are effective therapeutics for glycemic control in type 2 diabetes. Orally bioavailable orthosteric small-molecule...
Lynley D Pound et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E115-E123 (2014-05-23)
Children exposed to a maternal Western-style diet in utero have an increased risk of developing type 2 diabetes. Understanding the mechanisms and an investigation of possible interventions are critical to reversing this phenomenon. We examined the impact of maternal Western-style...
Elisabeth Streckel et al.
Journal of translational medicine, 13, 73-73 (2015-04-19)
The glucagon-like peptide-1 receptor (GLP1R) agonist liraglutide improves glycemic control and reduces body weight of adult type 2 diabetic patients. However, efficacy and safety of liraglutide in adolescents has not been systematically investigated. Furthermore, possible pro-proliferative effects of GLP1R agonists...
Aurélie P Ghaye et al.
BMC biology, 13, 70-70 (2015-09-04)
In contrast to mammals, the zebrafish has the remarkable capacity to regenerate its pancreatic beta cells very efficiently. Understanding the mechanisms of regeneration in the zebrafish and the differences with mammals will be fundamental to discovering molecules able to stimulate...
Bernard Thorens et al.
Diabetologia, 58(3), 558-565 (2014-12-17)
Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology...
Jennifer E Bruin et al.
Stem cell research, 12(1), 194-208 (2013-11-22)
Human embryonic stem cells (hESCs) were used as a model system of human pancreas development to study characteristics of the polyhormonal cells that arise during fetal pancreas development. HESCs were differentiated into fetal-like pancreatic cells in vitro using a 33-day...
Konstantin Bloch et al.
Hormones and behavior, 72, 1-11 (2015-05-07)
The treatment of rodents with non-competitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor, MK-801 (dizocilpine), induces symptoms of psychosis, deficits in spatial memory and impairment of synaptic plasticity. Recent studies have suggested that insulin administration might attenuate the cognitive dysfunctions through...
Ahmed M Abdellatif et al.
Experimental animals, 64(3), 305-312 (2015-04-29)
The members of the MAF family of transcription factors are homologs of v-Maf -the oncogenic component of the avian retrovirus AS42. The MAF family is subdivided into 2 groups, small and large MAFs. To elucidate the role of the large...
Ryuichi Wada et al.
Endocrine pathology, 25(4), 390-396 (2014-08-15)
Neuroendocrine neoplasm (NEN) of the pancreas and gastrointestinal tract is infrequent but often produces hormones to cause distinct clinical features. Glucagon-like peptide-1 receptor (GLP1R) is a G-protein coupled receptor for GLP1, which is cleaved by dipeptidyl peptidase (DPP)-IV, a peptidase...
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