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G4251

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Han Han et al.
The Journal of biological chemistry, 290(21), 13490-13499 (2015-04-03)
The endosomal sorting complexes required for transport (ESCRT) pathway drives reverse topology membrane fission events within multiple cellular pathways, including cytokinesis, multivesicular body biogenesis, repair of the plasma membrane, nuclear membrane vesicle formation, and HIV budding. The AAA ATPase Vps4
Mounira Chaki et al.
Plant science : an international journal of experimental plant biology, 238, 115-126 (2015-08-11)
Nitric oxide (NO) is a significant signalling molecule involved in the regulation of many different physiological processes in plants. One of the most imperative regulatory modes of action of NO is protein S-nitrosylation--the covalent attachment of an NO group to
Hanna Szaefer et al.
Drug and chemical toxicology, 37(4), 472-479 (2014-03-04)
Apples abundant in phenolic compounds show a variety of biological activities that may contribute to health beneficial effects against cardiovascular diseases, diabetes, obesity and cancer. We investigated the effect of cloudy apple juice (CAJ) on the hepatic and mammary gland
Paola Infante et al.
The EMBO journal, 34(2), 200-217 (2014-12-06)
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or independent mechanisms, all triggering
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 171-178 (2013-12-25)
Paracetamol (acetaminophen, APAP) is a commonly used analgesic drug. Known paracetamol metabolites include the glucuronide, sulfate and mercapturate. N-Acetyl-benzoquinonimine (NAPQI) is considered the toxic intermediate metabolite of paracetamol. In vitro and in vivo studies indicate that paracetamol is also metabolized
Roberta Ceci et al.
European journal of applied physiology, 115(3), 531-539 (2014-11-10)
Physical exercise is associated with enhanced production of reactive oxygen species, which if uncontrolled can result in tissue injury. Phosphodiesterase type 5 inhibitors (PDE5i) exhibit protective effect against oxidative stress, both in animals and healthy/unhealthy humans. However, the effect of
Tingfang Yi et al.
Nature communications, 6, 7194-7194 (2015-05-29)
MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 activities in RNAi and miR-451 biogenesis. Biochemical and NMR analyses
Lucia Banci et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6203-6208 (2014-04-16)
Monothiol glutaredoxins play a crucial role in iron-sulfur (Fe/S) protein biogenesis. Essentially all of them can coordinate a [2Fe-2S] cluster and have been proposed to mediate the transfer of [2Fe-2S] clusters from scaffold proteins to target apo proteins, possibly by
Hong-Mei Shan et al.
Biochemical and biophysical research communications, 456(3), 780-784 (2014-12-17)
Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression, DNA damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal kinase domain and the unique C-terminal polo-box domain (PBD). The PBD mediates diverse functions of
Angelina M M Basso et al.
AMB Express, 5, 20-20 (2015-04-09)
In Brazil, there is a growing demand for specialised pharmaceuticals, and the high cost of their importation results in increasing costs, reaching US$ 1.34 billion in 2012 and US$ 1.61 billion in 2013. Worldwide expenses related to drugs could reach
Chun-Feng Lu et al.
Ecotoxicology and environmental safety, 122, 537-544 (2015-10-04)
Growing evidence has confirmed that exposure to ambient particulate matters (PM) is associated with increased morbidity and mortality of cardiovascular and pulmonary diseases. Ambient PM is a complex mixture of particles and air pollutants. Harmful effects of PM are specifically
Daniil M Prigozhin et al.
PloS one, 9(12), e116249-e116249 (2015-01-01)
Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the pathogen, Mycobacterium tuberculosis, we carried out structural and phylogenetic analysis of two predicted
Rikiya Fukasawa et al.
Journal of biochemistry, 158(5), 373-384 (2015-05-24)
The Mediator complex (Mediator) plays key roles in transcription and functions as the nexus for integration of various transcriptional signals. Previously, we screened for Mediator cyclin-dependent kinase (CDK)-interacting factors and identified three proteins related to chromatin regulation. One of them
Katarina Smilkov et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 92, 25-31 (2014-06-29)
New (188)Re and (99m)Tc peptide conjugates with substance- P (SP) were prepared and biologically evaluated. The radiopharmaceuticals have been labelled with the [M≡N](2+) (M=(99m)Tc, (188)Re) core using a combination of π-donor tridentate and π-acceptor monodentate ancillary ligands. The new radiopharmaceuticals
Julia Cruces et al.
Journal of neuroimmunology, 277(1-2), 18-25 (2014-10-01)
Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially
Sang Sook Lee et al.
Plant, cell & environment, 38(10), 2071-2087 (2015-04-08)
Cyclophilin 18-2 (CYP18-2) genes, homologues of human peptidyl-prolyl isomerase-like 1 (PPiL1), are conserved across multicellular organisms and Schizosaccharomyces pombe. Although PPiL1 is known to interact with ski-interacting protein (SKIP), a transcriptional co-regulator and spliceosomal component, there have been no functional
Shakila Tobwala et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 261-272 (2014-09-24)
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U.S.
Han Shen et al.
Journal of experimental & clinical cancer research : CR, 34, 14-14 (2015-02-06)
Glioblastoma (GBM) is the most common and malignant primary brain tumor. In contrast to some other tumor types, aberrant glucose metabolism is an important component of GBM growth and chemoresistance. Recent studies of human orthotopic GBM in mice and in
Naphtali Savion et al.
Neuroscience letters, 583, 108-113 (2014-09-30)
Oxidative stress and/or low cellular glutathione are associated with development and progression of neurodegenerative diseases. We have shown that S-allylmercapto-N-acetylcysteine (ASSNAC) up-regulates the level of glutathione and phase II detoxifying enzymes in cultured vascular endothelial cells. The present study demonstrates
Ying-Hao Ho et al.
Journal of biomedical science, 22, 46-46 (2015-06-24)
Neuroinflammation with activation of microglia and production of proinflammatory cytokines in the brain plays an active role in epileptic disorders. Brain oxidative stress has also been implicated in the pathogenesis of epilepsy. Damage in the hippocampus is associated with temporal
Ayan K Ghosh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2081-2098 (2015-02-19)
Understanding the mechanism that allows the intracellular protozoan parasite Leishmania donovani (Ld) to respond to reactive oxygen species (ROS) is of increasing therapeutic importance because of the continuing resistance toward antileishmanial drugs and for determining the illusive survival strategy of
Vikash Pandey et al.
PloS one, 9(10), e111006-e111006 (2014-10-28)
Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation, ballooning and degradation of hepatocytes, and fibrosis.
Human islet isolation processing times shortened by one hour: minimized incubation time between tissue harvest and islet purification.
Magnus Ståhle et al.
Transplantation, 96(12), e91-e93 (2013-12-18)
Osamu Nakabayashi et al.
Communications biology, 4(1), 80-80 (2021-01-21)
Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates TNF-induced apoptosis through ubiquitylation of receptor-interacting protein kinase 1 (RIPK1) and cylindromatosis. Here we show that MIB2 bound and conjugated K48- and K63-linked polyubiquitin chains to
Jeannette Boutter et al.
Oncotarget, 5(22), 11501-11512 (2014-11-22)
Interactions with the bone marrow microenvironment are essential for leukemia survival and disease progression. We developed an imaging-based RNAi platform to identify protective cues from bone marrow derived mesenchymal stromal cells (MSC) that promote survival of primary acute lymphoblastic leukemia
Terukazu Sanui et al.
Journal of cellular biochemistry, 116(4), 628-639 (2014-11-18)
Sprouty was identified as an inhibitor of the fibroblast growth factor (FGF) receptor, and Sprouty2 (Spry2) functions as a negative regulator of receptor tyrosine kinase signaling. In this study, we investigated how inhibition of Spry2 affects osteoblasts and gingival epithelial
William K Gillette et al.
Scientific reports, 5, 15916-15916 (2015-11-03)
Prenylated proteins play key roles in several human diseases including cancer, atherosclerosis and Alzheimer's disease. KRAS4b, which is frequently mutated in pancreatic, colon and lung cancers, is processed by farnesylation, proteolytic cleavage and carboxymethylation at the C-terminus. Plasma membrane localization
Hanna Czeczot et al.
Acta biochimica Polonica, 53(1), 237-242 (2006-01-13)
We investigated glutathione level, activities of selenium independent GSH peroxidase, selenium dependent GSH peroxidase, GSH S-transferase, GSH reductase and the rate of lipid peroxidation expressed as the level of malondialdehyde in liver tissues obtained from patients diagnosed with cirrhosis or
Katharina Mahal et al.
Experimental cell research, 336(2), 263-275 (2015-06-24)
Histone deacetylases (HDAC) which play a crucial role in cancer cell proliferation are promising drug targets. However, HDAC inhibitors (HDACi) modelled on natural hydroxamic acids such as trichostatin A frequently lead to resistance or even an increased agressiveness of tumours.
Addison C McCarver et al.
The FEBS journal, 281(20), 4598-4611 (2014-08-13)
The thioredoxin system, composed of thioredoxin reductase (TrxR) and thioredoxin (Trx), is widely distributed in nature, where it serves key roles in electron transfer and in the defense against oxidative stress. Although recent evidence reveals Trx homologues are almost universally
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