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Kelly Cristina Mulder et al.
AMB Express, 5(1), 129-129 (2015-08-06)
Antimicrobial peptides are one of the most promising peptide-based drugs due to their enormous potential as novel biopharmaceuticals in both human and animal industries. In order to develop strategies to over produce such molecules, heterologous production of a modified version
Ilya Chumakov et al.
Scientific reports, 5, 7608-7608 (2015-01-09)
Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuronal and endothelial structures in this disease.
Jong-Hang Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 27-35 (2015-05-12)
This study explores human neuroblastoma (SH-SY5Y) and human glioblastoma (U-1240 MG) cellular differentiation changes under exposure to acrylamide (ACR). Differentiation of SH-SY5Y and U-1240 MG cells were induced by retinoic acid (RA) and butyric acid (BA), respectively. Morphological observations and
Anna Pennacchio et al.
PloS one, 10(7), e0132396-e0132396 (2015-07-15)
Antibiotics, such as benzyl-penicillin (PenG) and cephalosporin, are the most common compounds used in animal therapy. Their massive and illegal use in animal therapy and prophylaxis inevitably causes the presence of traces in foods of animal origin (milk and meat)
Lenka Stixová et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 27(1-2), 41-55 (2019-01-06)
Repair of ribosomal DNA (rDNA) is a very important nuclear process due to the most active transcription of ribosomal genes. Proper repair of rDNA is required for physiological biogenesis of ribosomes. Here, we analyzed the epigenetics of the DNA damage
Li Wang et al.
Biological & pharmaceutical bulletin, 38(11), 1779-1787 (2015-08-14)
Candida albicans is the most common cause of invasive fungal infections in humans. The C. albicans cell wall proteins play an important role in crucial host-fungus interactions and might be ideal vaccine targets to induce protective immune response in host.
Leandro Rodríguez-Viera et al.
PloS one, 9(9), e108875-e108875 (2014-10-01)
Crustaceans exhibit a remarkable variation in their feeding habits and food type, but most knowledge on carbohydrate digestion and utilization in this group has come from research on few species. The aim of this study was to make an integrative
Daymi Camejo et al.
Proteomics, 15(15), 2634-2642 (2015-04-29)
Pepper fruits in green and red maturation stages were selected to study the protein pattern modified by oxidation measuring carbonylated proteins in isolated mitochondria, together with the accumulation of superoxide radical and hydrogen peroxide in the fruits. MALDI-TOF/TOF analysis identified
Kun Huang et al.
The Plant journal : for cell and molecular biology, 98(2), 359-369 (2018-12-24)
Localization of mRNA and small RNAs (sRNAs) is important for understanding their function. Fluorescent in situ hybridization (FISH) has been used extensively in animal systems to study the localization and expression of sRNAs. However, current methods for fluorescent in situ detection of
Case studies: A hard look at GM crops.
Natasha Gilbert
Nature, 497(7447), 24-26 (2013-05-03)
Rajesh Arasada et al.
Journal of cell science, 128(13), 2259-2268 (2015-05-16)
F-BAR proteins are known to participate in cytokinesis, but their mechanisms are not well understood. Here we investigated Rga7p, an Schizosaccharomyces pombe F-BAR protein with a RhoGAP domain. Localization of Rga7p to the cytokinetic cleavage furrow depends on its F-BAR
Yan Cai et al.
BMC pulmonary medicine, 15, 72-72 (2015-07-17)
Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles, particularly in lung homeostasis
Zaki Shaikhibrahim et al.
International journal of cancer, 135(1), 19-26 (2014-01-01)
The mediator complex is an evolutionary conserved key regulator of transcription of protein-coding genes and an integrative hub for diverse signaling pathways. In this study, we investigated whether the mediator subunit MED15 is implicated in castration-resistant prostate cancer (CRPC). MED15
Alexander E Sorochinsky et al.
Amino acids, 45(5), 1017-1033 (2013-09-18)
This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation of chiral Ni(II) complexes of glycine Schiff bases using aldol and Mannich-type reactions. These reactions proceed with synthetically useful chemical
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Antonny Czarnecki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6389-6404 (2014-05-03)
A remarkable feature of early neuronal networks is their endogenous ability to generate spontaneous rhythmic electrical activity independently of any external stimuli. In the mouse embryonic SC, this activity starts at an embryonic age of ∼ 12 d and is
Chandan S Sagar et al.
Blood cells, molecules & diseases, 55(2), 104-107 (2015-07-05)
Thalassemia major is characterized by anemia, iron overload and cellular damage. The severity of symptoms correlates with the alpha/non-alpha globin imbalance and is proportional to the magnitude of alpha chain excess. Alpha hemoglobin stabilizing protein (AHSP), the erythroid specific alpha
Tone Berge Enger et al.
Acta odontologica Scandinavica, 72(7), 549-556 (2014-01-30)
Sjögren's Syndrome (SS) is a chronic autoimmune disease, leading to deficient secretion from salivary and lacrimal glands. Saliva production is normally increased by cholinergic innervation, giving rise to intracellular calcium signaling and water transport through water channels (aquaporins, AQPs). The
Sarah-Lynn E Martz et al.
Scientific reports, 5, 16094-16094 (2015-11-05)
Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and mortality worldwide, and perturbations of the gut microbiota are known to increase susceptibility to enteric infections. The purpose of this study was to investigate whether a Microbial
I Dransfield et al.
Cell death & disease, 6, e1646-e1646 (2015-02-20)
Billions of inflammatory leukocytes die and are phagocytically cleared each day. This regular renewal facilitates the normal termination of inflammatory responses, suppressing pro-inflammatory mediators and inducing their anti-inflammatory counterparts. Here we investigate the role of the receptor tyrosine kinase (RTK)
Y Wu et al.
Clinical and experimental immunology, 179(2), 277-293 (2014-09-18)
The role of NOD-like receptor family (NLRP3) has been confirmed in various inflammatory diseases. The association between NLRP3 and hyper-bileacidaemia during the sepsis remains unclear. We aimed to investigate whether NLRP3 silencing protects against the sepsis-induced hyper-bileacidaemia. Sepsis was induced
Fabiola Paciello et al.
Antioxidants (Basel, Switzerland), 10(8) (2021-08-28)
The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated
C H Zheng et al.
European cells & materials, 29, 224-236 (2015-04-22)
The 1,9-dimethylmethylene blue (DMMB) assay is widely used to quantify sulfated glycosaminoglycan (sGAG) contents of engineered tissues, culture media, tissue samples and bodily fluids, but the assay is subject to interference from polyanions such as hyaluronic acid (HA), DNA and
Marianela Galle et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 22(7-8), 696-704 (2015-07-05)
Geraniol (G) is a natural isoprenoid present in the essential oils of several aromatic plants, with various biochemical and pharmacologic properties. Nevertheless, the mechanisms of action of G on cellular metabolism are largely unknown. We propose that G could be
A Rossin et al.
Cell death and differentiation, 22(4), 643-653 (2014-10-11)
The death receptor Fas undergoes a variety of post-translational modifications including S-palmitoylation. This protein acylation has been reported essential for an optimal cell death signaling by allowing both a proper Fas localization in cholesterol and sphingolipid-enriched membrane nanodomains, as well
Julie Céline Brodeur et al.
Chemosphere, 112, 70-76 (2014-07-23)
The herbicide glyphosate and the insecticide cypermethrin are key pesticides of modern management in soy and corn cultures. Although these pesticides are likely to co-occur in ephemeral ponds or aquatic systems supporting amphibian wildlife, the toxicological interactions prevailing in mixtures
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
Haiwei Chen et al.
Cell, 177(5), 1217-1231 (2019-04-23)
The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria
Maria Belen Jaurena et al.
Nature communications, 6, 7476-7476 (2015-06-24)
All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here
Débora E Rinaldi et al.
Biochimica et biophysica acta, 1848(8), 1646-1655 (2015-04-29)
P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1-P5. The ion transported by the P5-ATPases is not known. Five genes named ATP13A1-ATP13A5 that belong to the P5-ATPase group are present in humans. Loss-of-function mutations
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