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Kate Lawrenson et al.
International journal of cancer, 137(8), 1806-1817 (2014-09-11)
Epithelial ovarian cancer (EOC) is still considered the most lethal gynecological malignancy and improved early detection of ovarian cancer is crucial to improving patient prognoses. To address this need, we tested whether candidate EOC biomarkers can be identified using three-dimensional...
Evelyn A Jähne et al.
Journal of pharmaceutical and biomedical analysis, 98, 235-246 (2014-06-21)
The compound (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolin-2-one (indolinone) was identified from lipophilic woad extracts (Isatis tinctoria L., Brassicaceae) as a compound possessing potent histamine release inhibitory and anti-inflammatory properties [1]. To further evaluate the potential of indolinone in terms of crossing the blood-brain barrier...
José Marco-Contelles et al.
Journal of medicinal chemistry, 52(9), 2724-2732 (2009-04-21)
Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent AChE inhibitors in the nanomolar...
J H Teixeira et al.
Oral diseases, 21(6), 713-720 (2015-03-11)
BubR1 and Mad2 are central components of the mitotic checkpoint complex that inhibits anaphase onset until all chromosomes are correctly aligned at the metaphase plate. We propose to analyse the combined expression of BubR1 and Mad2 and assess its significance...
Jason A Campagna et al.
Anesthesiology, 121(6), 1203-1216 (2014-08-30)
Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation "soft" (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM's pharmacology in beagle dogs in preparation for potential first in human phase 1 clinical trials....
Dian Liu et al.
Cell death & disease, 11(4), 224-224 (2020-04-10)
The apoptosis-stimulating protein of p53 (ASPP) family of proteins can regulate apoptosis by interacting with the p53 family and have been identified to play an important role in cancer progression. Previously, we have demonstrated that ASPP2 downregulation can promote invasion...
Melinda Westlund Schreiner et al.
Neuroscience and biobehavioral reviews, 57, 381-391 (2015-10-02)
Non-suicidal self-injury (NSSI) commonly starts in adolescence and is associated with an array of negative outcomes. Neurobiological research investigating NSSI is in its early stages and most studies have examined this behavior within the context of specific diagnoses. However, the...
Antonio Abengózar-Vela et al.
Investigative ophthalmology & visual science, 56(4), 2709-2719 (2015-06-13)
To determine the anti-inflammatory and antioxidant effects of quercetin (QCT) and/or resveratrol (RES) on human conjunctival (IOBA-NHC) and corneal (HCE) epithelial cell lines. IOBA-NHC and HCE cells were treated with QCT (0.5-25 μM), RES (0.5-50 μM) and a low-dose mixture...
Muhammad Saddiq Zahari et al.
Journal of proteome research, 14(9), 3882-3891 (2015-08-13)
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used...
Ye Zhao et al.
BMC cell biology, 15, 40-40 (2014-12-01)
Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated primary endothelial cells due to the unavailability of endothelial cell...
Brandon J Walters et al.
Scientific reports, 5, 17792-17792 (2015-12-08)
The mammalian cochlea is a highly specialized organ within the inner ear. Sensory hair cells (HC) in the cochlea detect and transduce sound waves into electrical impulses that are sent to the brain. Studies of the molecular pathways regulating HC...
Neil Gerard Quigley et al.
Chembiochem : a European journal of chemical biology, 21(19), 2836-2843 (2020-05-03)
αv β6 Integrin is an epithelial transmembrane protein that recognizes latency-associated peptide (LAP) and primarily activates transforming growth factor beta (TGF-β). It is overexpressed in carcinomas (most notably, pancreatic) and other conditions associated with αv β6 integrin-dependent TGF-β dysregulation, such...
Hong Wan et al.
Journal of medicinal chemistry, 52(6), 1693-1700 (2009-03-05)
In CNS drug discovery, knowledge of drug-tissue binding is essential for a better understanding of brain penetration by assessing unbound brain to plasma ratio as well as pharmacokinetics (PK) and pharmacodynamics (PD) relationship by relating free drug concentration to pharmacological...
Sean P Prall et al.
American journal of human biology : the official journal of the Human Biology Council, 27(6), 877-880 (2015-04-02)
Human immune function is strongly influenced by variation in hormone concentrations. The adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) are thought to be beneficial to immune function and disease resistance, but physiologically interact with testosterone and cortisol. We predict that...
Alvine C Mehinto et al.
Water research, 83, 303-309 (2015-07-16)
In vitro bioassays have shown promise as water quality monitoring tools. In this study, four commercially available in vitro bioassays (GeneBLAzer(®) androgen receptor (AR), estrogen receptor-alpha (ER), glucocorticoid receptor (GR) and progesterone receptor (PR) assays) were adapted to screen for...
Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise.
Peake JM, Tan SJ, Markworth JF, et al.
American Journal of Physiology. Endocrinology and Metabolism, 307(7), E539-E552 (2014)
Asher Castiel et al.
BMC cancer, 11, 412-412 (2011-09-29)
Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra centrosomes at two poles, thereby mimicking mitosis in normal cells. Failure of...
Nassima Belaidi et al.
Clinical biochemistry, 48(1-2), 89-92 (2014-12-03)
To extend knowledge about the clinical performances of a new chemiluminescent immunoassay (CLIA) for aldosterone set up in available analysers. We compared the results of a RIA assay to those of a CLIA assay in 198 serum and 80 urine...
Peter Vrtačnik et al.
Analytical biochemistry, 463, 38-44 (2014-07-02)
The accuracy of techniques such as microarrays, reverse transcription polymerase chain reaction, and whole transcriptome shotgun sequencing is critically dependent on RNA quality. We have repeatedly observed extensive RNA degradation following trypsinization, a routine procedure used to dissociate adherent tissue...
Diane C Homeyer et al.
Medical mycology, 53(3), 285-294 (2015-01-30)
Invasive fungal wound infections (IFIs) are increasingly reported in trauma patients and cause considerable morbidity and mortality despite standard of care treatment in trauma centers by experienced medical personnel. Topical agents such as oil of melaleuca, also known as tea...
Ioannis Gkouveris et al.
Oncology reports, 32(5), 2175-2182 (2014-09-02)
Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway possesses confirmed oncogenic potential in oral squamous cell carcinoma (OSCC). Crosstalk with other molecular pathways contributes to STAT3 regulation in cancer. The effects of mitogen-activated protein kinases (MAPKs) and...
Abdullah Hussain et al.
Immunology, 128(2), 236-244 (2009-09-11)
Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously...
Suzanne C Segerstrom et al.
Psychoneuroendocrinology, 49, 299-309 (2014-08-20)
The extant research is inconclusive regarding the best sampling methods to construct reliable measures of between-person differences in derived parameters of diurnal cortisol, and no study provides such recommendations for detecting within-person changes. These studies determined how many days of...
D Marini et al.
Australian veterinary journal, 93(8), 265-270 (2015-07-30)
To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep. Randomised experimental design with four treatment groups: three NSAID groups and one control group (n = 10/group). The study animals were 40 18-month-old Merino ewes with...
Ivana Klopčič et al.
Toxicology letters, 232(2), 376-383 (2014-12-03)
Endocrine-disrupting compounds can interfere with the endocrine organs or hormone system and cause tumors, birth defects and developmental disorders in humans. The estrogen-like activity of compounds has been widely studied but little is known concerning their possible modulation of the...
Iva Kulic et al.
The Journal of experimental medicine, 212(1), 37-52 (2014-12-17)
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ...
K Wesley Overton et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(41), E4386-E4393 (2014-10-01)
Phenotypic heterogeneity within a population of genetically identical cells is emerging as a common theme in multiple biological systems, including human cell biology and cancer. Using live-cell imaging, flow cytometry, and kinetic modeling, we showed that two states--quiescence and cell...
E H Mojumdar et al.
Biochimica et biophysica acta, 1838(10), 2473-2483 (2014-05-31)
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present...
Jaap J A J van der Velden et al.
Experimental dermatology, 24(4), 285-289 (2015-02-04)
Acral peeling skin syndrome (APSS, MIM #609796) is a rare autosomal recessive disorder characterized by superficial exfoliation and blistering of the volar and dorsal aspects of hands and feet. The level of separation is at the junction of the stratum...
Ji Hyun Seo et al.
BMC complementary medicine and therapies, 20(1), 176-176 (2020-06-07)
Glucocorticoids (GCs) are anti-inflammatory drugs widely used to treat acute and chronic inflammatory diseases. However, despite their excellent efficacy, the long-term use of GCs is relatively limited owing to their adverse effects. Recent studies have sought to reduce these adverse...
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