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Noriko Hikita-Watanabe et al.
Acta oto-laryngologica, 130(1), 79-83 (2009-05-14)
The 'tinnitus-rare' group had a poorer prognosis for hearing than the 'tinnitus-often' group in all sudden sensorineural hearing loss (SSNHL), although the 'shorter duration' group had better prognosis than the 'longer duration' when restricted to SSNHL accompanied by tinnitus. This...
Mark P Yeager et al.
Critical care medicine, 37(10), 2727-2732 (2009-11-04)
There is continuing controversy regarding the effect of glucocorticoids on a systemic inflammatory process. Based ona model of glucocorticoid action that includes both pro- and anti-inflammatory effects, we used the human experimental endotoxemia model to test the hypothesis that a...
Omprakash Shriwas et al.
Apoptosis : an international journal on programmed cell death, 25(3-4), 233-246 (2020-01-25)
Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is one of the major factors of treatment failure in OSCC. Human RNA helicase DDX3 plays an important...
[Rhabdomyolysis in severe acute asthma].
A Awab et al.
Annales francaises d'anesthesie et de reanimation, 28(2), 171-172 (2009-01-23)
Sami Karoui et al.
La Tunisie medicale, 86(4), 322-327 (2009-05-30)
To investigate the efficacy of azathioprine as maintenance therapy in acute severe colitis of Crohn's disease or ulcerative colitis after successful treatment by intravenous corticosteroids. We conduct an open prospective study between 1999 and 2004. All patients with acute severe...
Lingjie Li et al.
Cell stem cell, 24(2), 271-284 (2019-01-29)
Tissue development results from lineage-specific transcription factors (TFs) programming a dynamic chromatin landscape through progressive cell fate transitions. Here, we define epigenomic landscape during epidermal differentiation of human pluripotent stem cells (PSCs) and create inference networks that integrate gene expression...
Ryoukichi Ikeda et al.
Auris, nasus, larynx, 37(1), 114-116 (2009-05-05)
With the increase in the number of patients undergoing warfarin therapy, reports of complications due to such therapy have become frequent. Although upper airway obstruction secondary to bleeding resulting from warfarin therapy is rare, it is a life-threatening complication because...
Annett Isabel Walker et al.
International archives of allergy and immunology, 155(1), 86-92 (2010-11-27)
Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the administration of corticosteroids esterified with succinate. Skin tests, basophil activation tests...
C A Mini et al.
Toxicology in vitro : an international journal published in association with BIBRA, 71, 105069-105069 (2020-12-15)
Three-dimensional skin models, also named 3D skin models, human skin equivalents (HSEs), or Human Epidermal Equivalents (HEEs), have been increasingly used for chemical assessments in terms of efficacy and safety. Considering this, we developed an HEE model using immortalized HaCaT...
T Velpandian et al.
Methods and findings in experimental and clinical pharmacology, 32(3), 171-179 (2010-05-08)
The present study evaluated the protective action of calcium dobesilate (CDO) in various experimental models of cataract. CDO was studied in hydrocortisone-induced cataract in developing chick embryos and selenite-induced cataract in pups. CDO anti-cataract activity was also evaluated after oral...
Setsuko Morinaka
Auris, nasus, larynx, 36(5), 606-608 (2009-03-07)
A 73-year-old man presented to our hospital with a sore throat (left-sided) and hiccups. The patient had mucosal swelling and erosions affecting the left posterior pillar, base of tongue, epiglottis, arytenoid, and aryepiglottic fold. As the laryngeal mucosal edema became...
Ana Feliu et al.
Glia, 68(6), 1255-1273 (2020-01-03)
The failure to remyelinate and regenerate is a critical impediment to recovery in multiple sclerosis (MS), resulting in severe dysfunction and disability. The chondroitin sulfate proteoglycans (CSPGs) that accumulate in MS lesions are thought to be linked to the failure...
Jinhua Liu et al.
Nature communications, 9(1), 4386-4386 (2018-10-24)
In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular processes, their involvement in heme-dependent...
Daniel P Collins et al.
Hepatic medicine : evidence and research, 12, 79-92 (2020-07-02)
Research directed towards drug development, metabolism, and liver functions often utilize primary hepatocytes (PH) for preliminary in vitro studies. Variability in the in vitro functionality of PH and the unsuitability of hepatocarcinoma cells for these studies have driven researchers to...
Eleonora Nucera et al.
European journal of endocrinology, 164(1), 139-140 (2010-10-22)
We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes. The patient underwent an allergological evaluation (prick, intradermal, and patch tests) with hydrocortisone sodium succinate...
HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI).
Basharat, et al.
Toxicology and Applied Pharmacology, 408, 115279-115279 (2021)
Maiko Miyagawa et al.
Acta oto-laryngologica, 129(11), 1326-1329 (2009-10-30)
A 53-year-old male with fluctuating low frequency sensorineural hearing loss and tinnitus, but without vertigo, was evaluated by MRI obtained by intratympanic injection of a gadolinium-based contrast agent (GBCA) before and after the administration of isosorbide. The endolymphatic hydrops was...
Lars Hållström et al.
Critical care medicine, 36(11), 3043-3047 (2008-10-01)
Inhaled nitric oxide and glucocorticoids as a combination therapy may attenuate endotoxin-induced inflammatory responses in humans as indicated by levels of cytokines and clinical signs. Since other authors have shown that combined inhaled nitric oxide and steroids improved the histologic...
Andrew J Semark et al.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 15(1), 63-66 (2013-02-26)
Bolus dose concentrations of hydrocortisone (50mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of low concentrations of hydrocortisone sodium succinate (1 mg/ mL) with midazolam (1 mg/mL...
Takahiro Michiba et al.
Auris, nasus, larynx, 40(2), 162-166 (2012-07-31)
Some patients with sudden sensorineural hearing loss (SSNHL) are frustrated by residual tinnitus even after accomplishment of the treatment for SSNHL. In the present prospective study, we examined patients' backgrounds of sex, laterality and age together with changes in hearing...
Kelsey A Hart et al.
American journal of veterinary research, 73(1), 68-75 (2011-12-30)
To compare daily endogenous cortisol production rate and the pharmacokinetics of an i.v. bolus of hydrocortisone between neonatal foals and adult horses. 10 healthy full-term 2- to 4-day-old foals and 7 healthy adult horses. Blood samples were collected from each...
Jian-hua Lin et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 30(2), 377-378 (2010-02-18)
To study the therapeutic effect of glucocorticoid on early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation. Thirteen liver transplantation recipients with serum total bilirubin above 171 micromol/L at two weeks to one month postoperatively were enrolled in this study. After...
Rajagopal N Aravalli et al.
Hepatic medicine : evidence and research, 12, 15-27 (2020-02-28)
Primary human hepatocytes (PHHs) are the ideal candidates for studying critical liver functions such as drug metabolism and toxicity. However, as they are isolated from discarded livers that are unsuitable for transplantation, they possess limited expansion ability in vitro and...
Joost Schalkwijk et al.
Science translational medicine, 11(510) (2019-09-20)
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum parasites and also blocked transmission of sexual stages to...
Crenguta Livia Calma et al.
Tropical doctor, 42(1), 54-55 (2011-11-08)
This case report focuses on hydatidosis, one of the most important parasitic zoonoses in Romania. We describe an interesting paediatric case of an eight-year old boy from a rural region presenting with a both giant and life-threatening pulmonary cyst (that...
Brian H Cuthbertson et al.
Intensive care medicine, 35(11), 1868-1876 (2009-08-05)
Use of etomidate in the critically ill is controversial due to its links with an inadequate response to corticotropin and potential for excess mortality. In a septic shock population, we tested the hypotheses that etomidate administration induces more non-responders to...
Jian Liu et al.
Journal of neuroscience research, 98(7), 1498-1513 (2020-03-14)
The neuroretina is protected by its own defense system, that is microglia and the complement system. Under normal physiological conditions, microglial activation is tightly regulated by the neurons although the underlying mechanism remains elusive. Using published single-cell RNA sequencing data...
Wendy Saltzman et al.
Psychoneuroendocrinology, 34(8), 1222-1234 (2009-04-14)
Both acute and chronic stress can impair maternal behavior and increase rates of infant abuse in several species. The mechanisms inducing these effects are unknown, but experimental manipulation of circulating corticosterone levels alters maternal behavior in rats, and circulating or...
Susan W Aucott et al.
Pediatrics, 122(4), 775-781 (2008-10-03)
Relative adrenal insufficiency in extremely low birth weight infants may contribute to significant morbidity and death. Our objective was to evaluate the relationship between cortisol concentrations and short-term outcomes. Cortisol concentrations were obtained for 350 intubated, extremely low birth weight...
E Autret-Leca et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 16(7), 999-1004 (2009-05-05)
In 1999, 80% of French neonatal centers used corticosteroids, mainly betamethasone (BMT), to prevent or treat bronchopulmonary dysplasia (BPD) [Lee SK, McMillan DD, Ohlson A, et al. Variations in practice and outcomes in the canadian NICU Network 1996-1997. Pediatrics 2000;106:1070-9]....
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