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H6648

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Jamie L Fornek et al.
Journal of virology, 83(21), 11102-11115 (2009-08-21)
The transmission of H5N1 influenza viruses from birds to humans poses a significant public health threat. A substitution of glutamic acid for lysine at position 627 of the PB2 protein of H5N1 viruses has been identified as a virulence determinant.
Kevin Enck et al.
Current pharmaceutical design, 26(26), 3134-3140 (2020-02-11)
There is a significant interest in effective oral drug delivery of therapeutic substances. For probiotics, there is a particular need for a delivery platform that protects the bacteria from destruction by the acidic stomach while enabling targeted delivery to the
Hamideh Babaloo et al.
Journal of cellular physiology, 234(7), 11060-11069 (2018-12-26)
The significant consequences of spinal cord injury (SCI) include sensory and motor disability resulting from the death of neuronal cells and axon degeneration. In this respect, overcoming the consequences of SCI including the recovery of sensory and motor functions is
Daria Fresia et al.
Journal of clinical medicine, 10(11) (2021-07-03)
Glucose is one of the most important metabolic substrates of the retina, and glycaemic imbalances can lead to serious side effects, including retinopathy. We previously showed that hypoglycaemia induces retinal cell death in mice, as well as the implication of
Vickie H Y Wong et al.
Experimental eye research, 202, 108348-108348 (2020-11-10)
To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal suture in mice. Ocular hypertension (OHT) was induced by applying a circumlimbal suture behind the limbus in male adult C57BL6/J mice. In the OHT group
Chuanfang Li et al.
Experimental physiology, 105(6), 1035-1049 (2020-01-09)
What is the central question of this study? What is the role of microRNA-424-5p (miR-424-5p) in aortic smooth muscle cells? How does miR-424-5p function as a suppressor of the inflammatory response? What is the main finding and its importance? Upregulation
Sarah E W Grubb et al.
Infection and immunity, 77(9), 3872-3878 (2009-07-08)
Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the circulation to distant organs, where it causes multiple organ failure. Despite the severity of systemic C. albicans infection
Zheng Cao et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118718-118718 (2020-04-15)
Alternative splicing enables G protein-coupled receptor (GPCR) genes to greatly increase the number of structurally and functionally distinct receptor isoforms. However, the functional role and relevance of the individual GPCR splice variants in regulating physiological processes are still to be
Zheng-Shun Wen et al.
Marine drugs, 9(6), 1038-1055 (2011-07-13)
The study was conducted to investigate the promoted immune response to ovalbumin in mice by chitosan nanoparticles (CNP) and its toxicity. CNP did not cause any mortality or side effects when mice were administered subcutaneously twice with a dose of
Patricia Meyer et al.
Stem cells and development, 29(9), 574-585 (2020-01-23)
Hypoxic-ischemic brain injury is the leading cause of disability and death after successful resuscitation from cardiac arrest, and, to date, no specific treatment option is available to prevent subsequent neurofunctional impairments. The hippocampal cornu ammonis segment 1 (CA1) is one
F Ruffinatti et al.
Current Alzheimer research, 15(11), 986-1004 (2018-06-14)
It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis
Kiran Kundu et al.
Cancer immunology research, 7(7), 1120-1134 (2019-06-06)
mAb-based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T-cell-based adaptive immune responses in patients with cancer. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb
Trim Lajqi et al.
Frontiers in immunology, 11, 546415-546415 (2020-10-27)
Microglia, the innate immune cells of the central nervous system, feature adaptive immune memory with implications for brain homeostasis and pathologies. However, factors involved in the emergence and regulation of these opposing responses in microglia have not been fully addressed.
Ofer Elhanani et al.
Cell reports, 31(5), 107591-107591 (2020-05-07)
The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a limited understanding of the underlying mechanisms. Using an in vitro
Elisa Boutet-Robinet et al.
STAR protocols, 2(4), 100872-100872 (2021-11-09)
We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin. In this protocol, we describe the specific steps for assessing
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Anisuzzaman et al.
Frontiers in immunology, 12, 635622-635622 (2021-05-11)
Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of Schistosoma mansoni, into adult worms. This natural course of infection can be mimicked in experimental mouse models
Jan Krivanek et al.
Nature communications, 11(1), 4816-4816 (2020-09-25)
Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the
María Isabel Hernández-Alvarez et al.
Cell, 177(4), 881-895 (2019-05-06)
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2
Uxía Nogueira-Recalde et al.
EBioMedicine, 45, 588-605 (2019-07-10)
Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. Human chondrocytes with IL-6 induced
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Susanna Sforzini et al.
Environmental pollution (Barking, Essex : 1987), 196, 60-71 (2014-10-12)
In this study, a battery of biomarkers was utilised to evaluate the stress syndrome induced in the earthworm Eisenia andrei by exposure to environmentally realistic concentrations of benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) in OECD soil. The set of tests was
Weronika Piorońska et al.
BMC cancer, 21(1), 1006-1006 (2021-09-10)
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is unclear. We examined the expression pattern of PRRX1 in nine
Aziliz Lecomte et al.
Advanced biosystems, 4(11), e2000114-e2000114 (2020-11-03)
Brain organoids is an exciting technology proposed to advance studies on human brain development, diseases, and possible therapies. Establishing and applying such models, however, is hindered by the lack of technologies to chronically monitor neural activity. A promising new approach
A Nicolas et al.
Lab on a chip, 21(9), 1676-1685 (2021-04-17)
Assessment of epithelial barrier function is critically important for studying healthy and diseased biological models. Here we introduce an instrument that measures transepithelial electrical resistance (TEER) of perfused epithelial tubes in the microfluidic OrganoPlate platform. The tubules are grown in
Caroline Perner et al.
STAR protocols, 2(1), 100333-100333 (2021-02-23)
In this protocol, we provide step-by-step instructions for dissection and culture of primary murine dorsal root ganglia (DRG), which provide an opportunity to study the functional properties of peripheral sensory neurons in vitro. Further, we describe the analysis of neuropeptide
Elżbieta Łopieńska-Biernat et al.
Pathogens (Basel, Switzerland), 9(12) (2020-12-16)
Anisakis simplex (s.l.) is a complex of three sibling (biological) species of parasitic nematodes of marine mammals, including A. berlandi, A. pegreffii and A. simplex (s.s.). It is characterized by a complex life cycle in which humans can become accidental
Afshin Fathi et al.
Journal of biological engineering, 14(1), 27-27 (2020-12-10)
Hybrid fibrous mat containing cell interactive molecules offers the ability to deliver the cells and drugs in wound bed, which will help to achieve a high therapeutic treatment. In this study, a co-electrospun hybrid of polyvinyl alcohol (PVA), chitosan (Ch)
Ofer Elhanani et al.
STAR protocols, 1(2), 100096-100096 (2020-10-29)
The potential of reprogrammed β cells derived from pancreatic exocrine cells to treat diabetes has been demonstrated in animal models. However, the precise mechanisms and regulators involved in this process are not clear. Here, we describe a method that allows
Bart Kramer et al.
International journal of molecular sciences, 20(18) (2019-09-25)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current
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