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Bart Kramer et al.
International journal of molecular sciences, 20(18) (2019-09-25)
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current
Robin Püllen et al.
Cells, 10(7) (2021-08-08)
Formation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dramatically. However, comparative studies between embryonic
Marina Angélica Marciano et al.
Clinical oral investigations, 19(9), 2201-2209 (2015-04-30)
The aim of this research was to analyse the dental discolouration caused by mineral trioxide aggregate (MTA) induced by bismuth oxide and also assess the colour stability of other dental cements. Bismuth oxide, calcium tungstate and zirconium oxide were placed
Pranjali Yadav et al.
ACS biomaterials science & engineering, 5(12), 6590-6601 (2019-12-09)
A mesoporous magnetic nanohybrid functionalized with 14 wt % carbon nitride (CN) and loaded with curcumin (Cur) has been developed as a combination platform for photodynamic therapy and magnetic hyperthermia. CN-Cur complexes on the nanoparticle surface facilitate fast charge separation
Luisa Zupin et al.
Journal of biophotonics, 12(10), e201900043-e201900043 (2019-06-21)
Laser therapy, also known as Photobiomodulation (PBM) is indicated to reduce pain associated with different pathologies and applied using protocols that vary in wavelength, irradiance and fluence. Its mechanisms of action are still unclear and possibly able to directly impact
Hae-Ran Park et al.
BMC cancer, 9, 85-85 (2009-03-19)
Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer
Percíllia Victória Santos de Oliveira et al.
Redox biology, 22, 101142-101142 (2019-03-15)
Redox-related plasma proteins are candidate reporters of protein signatures associated with endothelial structure/function. Thiol-proteins from protein disulfide isomerase (PDI) family are unexplored in this context. Here, we investigate the occurrence and physiological significance of a circulating pool of PDI in
Marisa Zallocchi et al.
JCI insight, 6(5) (2021-01-22)
Hair cell loss is the leading cause of hearing and balance disorders in humans. It can be caused by many factors, including noise, aging, and therapeutic agents. Previous studies have shown the therapeutic potential of quinoxaline against drug-induced ototoxicity. Here
Anthony Laugeray et al.
Neurotoxicity research, 33(1), 87-112 (2017-09-08)
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in offspring later in life. In the present study
A Tampieri et al.
Nanotechnology, 22(1), 015104-015104 (2010-12-08)
Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, in the presence of magnetite nano-particles. The magnetic phase acted as a sort of cross-linking agent for the collagen, inducing a chemico-physical-mechanical stabilization of the material
Manuela Estermann et al.
PloS one, 15(12), e0241500-e0241500 (2020-12-04)
The presence of ascites in the peritoneal cavity leads to morphological and functional changes of the peritoneal mesothelial cell layer. Cells loose cell-cell interactions, rearrange their cytoskeleton, activate the production of fibronectin, and change their cell surface morphology in a
Zheng-Shun Wen et al.
Marine drugs, 9(6), 1038-1055 (2011-07-13)
The study was conducted to investigate the promoted immune response to ovalbumin in mice by chitosan nanoparticles (CNP) and its toxicity. CNP did not cause any mortality or side effects when mice were administered subcutaneously twice with a dose of
Sevdan Yılmaz et al.
Fish & shellfish immunology, 78, 140-157 (2018-04-24)
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight
Jelena M Kezic et al.
Experimental eye research, 193, 107995-107995 (2020-03-12)
There is accumulating evidence that aging shifts the central nervous system milieu towards a proinflammatory state, with increased reactivity of microglia in the aging eye and brain having been implicated in the development of age-related neurodegenerative conditions. Indeed, alterations to
Laura K Olsen et al.
Brain, behavior, and immunity, 80, 525-535 (2019-04-29)
Evidence is accumulating to suggest that viral infections and consequent viral-mediated neuroinflammation may contribute to the etiology of idiopathic Parkinson's disease. Moreover, viruses have been shown to influence α-synuclein oligomerization as well as the autophagic clearance of abnormal intra-cellular proteins
Hao-Kuang Wang et al.
Journal of inflammation research, 14, 2363-2376 (2021-06-10)
Cerebral ischemia is a leading cause of disability and death worldwide. However, an effective therapeutic approach for the condition remains undiscovered. The previously proposed growth factor-based therapy has been inefficient due to its inability to pass through the blood-brain barrier.
Hideaki Oike et al.
PloS one, 6(8), e23709-e23709 (2011-09-09)
The circadian clock is closely associated with energy metabolism. The liver clock can rapidly adapt to a new feeding cycle within a few days, whereas the lung clock is gradually entrained over one week. However, the mechanism underlying tissue-specific clock
Janhavi Sharma et al.
Journal of immunological methods, 351(1-2), 30-35 (2009-10-06)
One of the initial steps in the inflammatory process involves the adherence and transmigration of circulating polymorphonuclear leukocytes (PMN) across the endothelial cell monolayer. One of the main constituents of the neutrophil phagosome that contributes to bacterial killing is myeloperoxidase
Martin Pšenička et al.
Theriogenology, 83(6), 1085-1092 (2015-01-07)
We report, for the first time, a series of baseline techniques comprising isolation and transplantation of female and male early-stage germ cells in sturgeon to generate a germline chimera as a potential tool for surrogate reproduction and gene banking. Cells
Sarah E W Grubb et al.
Infection and immunity, 77(9), 3872-3878 (2009-07-08)
Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the circulation to distant organs, where it causes multiple organ failure. Despite the severity of systemic C. albicans infection
Kevin Enck et al.
Current pharmaceutical design, 26(26), 3134-3140 (2020-02-11)
There is a significant interest in effective oral drug delivery of therapeutic substances. For probiotics, there is a particular need for a delivery platform that protects the bacteria from destruction by the acidic stomach while enabling targeted delivery to the
F Ruffinatti et al.
Current Alzheimer research, 15(11), 986-1004 (2018-06-14)
It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis
Elisa Boutet-Robinet et al.
STAR protocols, 2(4), 100872-100872 (2021-11-09)
We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin. In this protocol, we describe the specific steps for assessing
Chuanfang Li et al.
Experimental physiology, 105(6), 1035-1049 (2020-01-09)
What is the central question of this study? What is the role of microRNA-424-5p (miR-424-5p) in aortic smooth muscle cells? How does miR-424-5p function as a suppressor of the inflammatory response? What is the main finding and its importance? Upregulation
Daria Fresia et al.
Journal of clinical medicine, 10(11) (2021-07-03)
Glucose is one of the most important metabolic substrates of the retina, and glycaemic imbalances can lead to serious side effects, including retinopathy. We previously showed that hypoglycaemia induces retinal cell death in mice, as well as the implication of
Patricia Meyer et al.
Stem cells and development, 29(9), 574-585 (2020-01-23)
Hypoxic-ischemic brain injury is the leading cause of disability and death after successful resuscitation from cardiac arrest, and, to date, no specific treatment option is available to prevent subsequent neurofunctional impairments. The hippocampal cornu ammonis segment 1 (CA1) is one
Zheng Cao et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118718-118718 (2020-04-15)
Alternative splicing enables G protein-coupled receptor (GPCR) genes to greatly increase the number of structurally and functionally distinct receptor isoforms. However, the functional role and relevance of the individual GPCR splice variants in regulating physiological processes are still to be
Vickie H Y Wong et al.
Experimental eye research, 202, 108348-108348 (2020-11-10)
To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal suture in mice. Ocular hypertension (OHT) was induced by applying a circumlimbal suture behind the limbus in male adult C57BL6/J mice. In the OHT group
Jamie L Fornek et al.
Journal of virology, 83(21), 11102-11115 (2009-08-21)
The transmission of H5N1 influenza viruses from birds to humans poses a significant public health threat. A substitution of glutamic acid for lysine at position 627 of the PB2 protein of H5N1 viruses has been identified as a virulence determinant.
Kiran Kundu et al.
Cancer immunology research, 7(7), 1120-1134 (2019-06-06)
mAb-based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T-cell-based adaptive immune responses in patients with cancer. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb
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