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Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Pil H Lee et al.
Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08)
A multiple linear regression QSAR model was developed based on a set of 61 compounds with internally consistent permeability data measured across Franz cell. The data was normalized using a mean permeability value of a reference compound, 3-isobutyl-1-methylxanthine (IBMX). The...
M Debono et al.
Best practice & research. Clinical endocrinology & metabolism, 23(2), 221-232 (2009-06-09)
Current therapy with immediate-release hydrocortisone is the most commonly used regimen for replacement in patients with primary and secondary adrenal insufficiency. However, conventional hydrocortisone cannot provide the physiological rhythm of cortisol release. Physicians have used fixed twice- or thrice-daily doses...
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry, 17(20), 7313-7323 (2009-09-25)
The 80% aqueous acetone extract from the fruit of Piper chaba (Piperaceae) was found to have hepatoprotective effects on D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice. From the ethyl acetate-soluble fraction, three new amides, piperchabamides E, G, and H, 33 amides...
Animesh N Sharma et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(9), R627-R635 (2014-02-28)
How sex steroids modulate glucocorticoid feedback on the hypothalamic-pituitary-corticotrope (HPC) unit is controversial in humans. We postulated that testosterone (T) in men and estradiol (E2) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion. To test this hypothesis, 24...
Charmaine S Tam et al.
Metabolism: clinical and experimental, 63(2), 194-198 (2013-11-26)
The effect of weight loss by diet or diet and exercise on salivary cortisol levels, a measure of hypothalamic pituitary adrenal activity, in overweight individuals is not known. The objective was to test the hypothesis that 24 weeks of moderate...
M J Hannon et al.
The Journal of clinical endocrinology and metabolism, 99(1), 291-298 (2013-11-20)
Hyponatremia is common after acute subarachnoid hemorrhage (SAH) but the etiology is unclear and there is a paucity of prospective data in the field. The cause of hyponatremia is variously attributed to the syndrome of inappropriate antidiuresis (SIAD), acute glucocorticoid...
Wei-Hua Jiao et al.
Journal of natural products, 73(2), 167-171 (2010-01-26)
Four new bis-beta-carboline alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first reported bis-beta-carboline alkaloid possessing a novel cyclobutane moiety. The structures of...
Chrysostomos S Katsenos et al.
Critical care medicine, 42(7), 1651-1657 (2014-03-29)
To investigate the impact of early initiation of hydrocortisone therapy on the clinical course of septic shock and on cytokine release. Prospective study in patients with septic shock treated with low doses of hydrocortisone. ICUs and general wards. Over a...
E S Husebye et al.
Journal of internal medicine, 275(2), 104-115 (2013-12-18)
Primary adrenal insufficiency (PAI), or Addison's disease, is a rare, potentially deadly, but treatable disease. Most cases of PAI are caused by autoimmune destruction of the adrenal cortex. Consequently, patients with PAI are at higher risk of developing other autoimmune...
Irene Cortés-Puch et al.
American journal of physiology. Endocrinology and metabolism, 307(11), E994-E1008 (2014-10-09)
The clinical significance and even existence of critical illness-related corticosteroid insufficiency is controversial. Here, hypothalamic-pituitary-adrenal (HPA) function was characterized in severe canine Staphylococcus aureus pneumonia. Animals received antibiotics and titrated life-supportive measures. Treatment with dexamethasone, a glucocorticoid, but not desoxycorticosterone...
Antonio Marzio et al.
Molecular cell, 73(2), 224-237 (2018-12-18)
The BRCA1-BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently disrupted in breast cancers. PARP inhibitors (PARPis) are used clinically to treat BRCA-mutated breast tumors. Using a genetic screen, we identified EMI1 as a modulator of PARPi...
Zofia Ostrowska et al.
Postepy higieny i medycyny doswiadczalnej (Online), 67, 433-441 (2013-06-12)
It has been suggested that disturbances in melatonin (MEL) secretion might play a role in osteoporosis development in females with anorexia nervosa (AN). It might be hypothesized that changes in the levels of hormones of the pituitary-ovarian, -thyroid and -adrenocortical...
Giorgio Ottaviani et al.
Journal of medicinal chemistry, 49(13), 3948-3954 (2006-06-23)
This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for a set of compounds...
Patsy Lenane et al.
JAMA dermatology, 150(1), 47-50 (2013-11-15)
Alopecia areata is an idiopathic cause of hair loss with limited therapeutic repertoire. To compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients. This single-center, randomized, blind, 2-arm, parallel-group, superiority trial was carried out...
K Kahveci et al.
Nigerian journal of clinical practice, 17(4), 523-527 (2014-06-10)
The aim of this study was to investigate the effect of different types of anesthesia on stress hormones. The study was included 60 ASAI-II cases scheduled for major lower extremity surgery. The cases were randomized into 2 groups: The EA...
Janna L Friedly et al.
The New England journal of medicine, 371(1), 11-21 (2014-07-06)
Epidural glucocorticoid injections are widely used to treat symptoms of lumbar spinal stenosis, a common cause of pain and disability in older adults. However, rigorous data are lacking regarding the effectiveness and safety of these injections. In a double-blind, multisite...
Guodong Zhao et al.
The Journal of surgical research, 193(1), 223-228 (2014-09-27)
To identify the effect of ulinastatin (UTI) administration on stress-induced hyperglycemia and acute insulin (INS) resistance experienced by patients undergoing partial hepatectomy. Forty-six patients undergoing partial hepatectomy were assigned randomly to the control group (group C) or UTI treatment group...
Carla Giordano et al.
European journal of endocrinology, 170(2), 311-319 (2013-11-21)
Diabetes mellitus (DM) is one of the most frequent complications of Cushing's syndrome (CS). The aim of this study was to define the changes in insulin sensitivity and/or secretion in relation to glucose tolerance categories in newly diagnosed CS patients....
John W Ingle et al.
The Laryngoscope, 124(4), 921-927 (2014-01-30)
Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid...
Huang Tang et al.
Bioorganic & medicinal chemistry letters, 22(6), 2257-2261 (2012-02-22)
A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced β-amyloid (Aβ) aggregation. The synthetic compounds exhibited high AChE inhibitory activity with IC(50)...
Rajesh Aneja et al.
Archives of disease in childhood, 92(2), 165-169 (2006-09-28)
Recent studies show that children who die from fulminant meningococcaemia have very low cortisol:adrenocorticotrophic hormone (ACTH) ratios within the first 8 h of presentation to emergency facilities compared with survivors. This observation supports the possibility that adrenal insufficiency may contribute...
Gudmundur Johannsson et al.
Hormone research, 68 Suppl 5, 182-188 (2008-02-07)
Glucocorticoid (GC) deficiency is a consequence of various disorders that are by themselves rare. Because of this low prevalence, the low cost of GC replacement therapy and the belief that existing outcomes are good, there has been little interest in...
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry letters, 18(6), 2038-2042 (2008-02-22)
The methanolic extract from the fruit of Piper chaba (Piperaceae) was found to have a hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. From the ethyl acetate-soluble fraction, a new amide constituent named piperchabamide E together with twenty...
Partial hypopituitarism: a sequel of extrapontine myelinosis.
Subodh Banzal et al.
Neurology India, 61(3), 307-308 (2013-07-19)
Muhammad Alimuddin et al.
Journal of medicinal chemistry, 51(16), 5140-5142 (2008-08-01)
A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2)...
Jitske Tiemensma et al.
European journal of endocrinology, 171(2), 171-182 (2014-05-08)
A high prevalence of psychological morbidity and maladaptive personality as well as impaired quality of life (QoL) is observed in patients with and without hydrocortisone dependency following (cured) Cushing's syndrome. However, it is currently unclear whether a similar pattern is...
Timing of corticosteroids in refractory septic shock: a key or wishful thinking?*.
Steven B Greenberg et al.
Critical care medicine, 42(7), 1733-1735 (2014-06-17)
Evidence accumulating that depression may hinder survival.
Vicki Brower
Journal of the National Cancer Institute, 106(1), djt446-djt446 (2014-01-10)
Markus A Lill et al.
Journal of medicinal chemistry, 48(18), 5666-5674 (2005-09-02)
We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis, we simulated the...
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