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Teneale A Stewart et al.
ACS pharmacology & translational science, 3(1), 63-75 (2020-04-08)
An essential process in predicting the in vivo pharmacological activity of a candidate molecule involves the evaluation of target responses using established model systems. While these models largely comprise immortalized cells, which are often serially passaged as monolayers on uniformly...
Mehmet Soner Türküner et al.
Cell biology international, 44(3), 744-754 (2019-11-27)
Recent epidemiologic studies pointed out a significant correlation between dietary monosodium glutamate (MSG) and increased body mass index. Corroborating evidences came from animal studies depicting a clear association between dietary MSG intake and increased abdominal fat, dyslipidemia, adipocyte hypertrophy, and...
Jamie Sharp et al.
Biotechnology progress, 34(2), 432-444 (2017-12-02)
Few studies report whole pancreatic tissue culture, as it is a difficult task using traditional culture methods. Here, a factorial design was used to investigate the singular and combinational effects of flow, dissolved oxygen concentration (D.O.) and pulsation on whole...
Nadia Badolati et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-15)
Liver diseases affect millions of people worldwide. In most of the cases, severe hepatic dysfunction and liver cancer stem from mild and common clinical signs including hepatic steatosis, insulin resistance, liver inflammation, and oxidative stress, all together referred to as...
Fabien Cannac et al.
Science advances, 6(16), eaay7928-eaay7928 (2020-06-05)
The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by secretion of a dually lipid-modified morphogen, Hh, a process dependent on a membrane-integral protein Dispatched. Although Dispatched...
Niklas Mejhert et al.
Molecular cell, 77(6), 1251-1264 (2020-02-06)
Lipid droplets (LDs) store lipids for energy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that...
Leanne Woods-Burnham et al.
The Prostate, 77(16), 1601-1608 (2017-10-17)
Understanding how biological factors contribute to prostate cancer (PCa) health disparities requires mechanistic functional analysis of specific genes or pathways in pre-clinical cellular and animal models of this malignancy. The 22Rv1 human prostatic carcinoma cell line was originally derived from...
Leanne Woods-Burnham et al.
Scientific reports, 8(1), 15063-15063 (2018-10-12)
Glucocorticoid receptor (GR) is emerging as a key driver of prostate cancer (PCa) progression and therapy resistance in the absence of androgen receptor (AR) signaling. Acting as a bypass mechanism, GR activates AR-regulated genes, although GR-target genes contributing to PCa...
Mikkel Morsing et al.
Breast cancer research : BCR, 22(1), 102-102 (2020-10-01)
Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs consist of unique parenchymal entities embedded within...
Taha Azad et al.
Oncogene, 39(2), 334-355 (2019-09-04)
The Hippo pathway has emerged as a key signaling pathway that regulates various biological functions. Dysregulation of the Hippo pathway has been implicated in a broad range of human cancer types. While a number of stimuli affecting the Hippo pathway...
Carmen Hurtado Del Pozo et al.
Cell reports, 28(3), 773-791 (2019-07-18)
Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this receptor...
Ke Chen et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 3535-3549 (2020-10-30)
Multiple symmetric lipomatosis (MSL) is a rare disease showing chronic progression of multiple, symmetrical, and non-encapsulated subcutaneous lipoma. The cause of the disease remains unknown. This study reported and summarized 13 sporadic cases of Type I MSL patients in terms...
B J Thering et al.
Journal of dairy science, 92(5), 2027-2037 (2009-04-25)
Studying long-chain fatty acid (LCFA) effects on gene network expression in bovine cells could provide useful information for future practical applications. An optimized in vitro system that does not require tissue collection or cell isolation could fill a niche in...
Minnie Rangarajan et al.
Journal of bacteriology, 190(8), 2920-2932 (2008-02-12)
We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance. APS is a phosphorylated branched mannan that shares a common epitope with posttranslational additions to some of the Arg-gingipains....
Jienny Lee et al.
Bioscience reports, 40(4) (2020-04-02)
Mesenchymal stem cells (MSCs) possess the ability to differentiate into multiple cell lineages, and thus, confer great potential for use in regenerative medicine and biotechnology. In the present study, we attempted to isolate and characterize bovine tongue tissue epithelium-derived MSCs...
Xiaofei Tian et al.
Frontiers in psychiatry, 11, 815-815 (2020-09-10)
Delayed neurologic sequelae (DNS) are recurrent-transient neuropsychiatric consequences of carbon monoxide (CO) intoxication. Pathologically DNS features damages to the brain white matter. Here we test a hypothesis that direct cytotoxicity of CO to oligodendrocytes plays a role in the development...
Soham Chanda et al.
Cell stem cell, 25(1), 103-119 (2019-06-04)
Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic expression of proneural transcription factors. Here we show that directly reprogrammed neurons, despite their rapid maturation kinetics, can model teratogenic mechanisms that specifically affect early neurodevelopment. We...
Taiichi Tsuyama et al.
The Journal of cell biology, 216(3), 815-834 (2017-02-18)
Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which...
Chelsea Hepler et al.
eLife, 7 (2018-09-29)
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to identify and isolate functionally distinct subpopulations...
Sanjeev Sharma et al.
Cell reports, 27(7), 1979-1990 (2019-05-16)
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. We report that in Drosophila, phosphatidylinositol 5 phosphate 4-kinase (PIP4K) is...
Themis Thoudam et al.
Diabetes, 68(3), 571-586 (2018-12-14)
Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca2+ transport from the ER to mitochondria via an IP3R1-GRP75-VDAC1 complex-dependent mechanism. Excessive MAM formation may cause mitochondrial Ca2+ overload and mitochondrial dysfunction....
Ken Kobayashi et al.
Journal of mammary gland biology and neoplasia, 23(1-2), 75-88 (2018-04-11)
In lactating mammary glands, alveolar mammary epithelial cells (MECs) synthesize and secrete milk components. MECs also form less permeable tight junctions (TJs) to prevent the leakage of milk components. During lactation, MECs are exposed to temperature changes by metabolic heat...
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose...
Zhen Luo et al.
American journal of physiology. Cell physiology, 316(2), C198-C209 (2018-11-30)
Significant embryo loss remains a serious problem in pig production. Reactive oxygen species (ROS) play a critical role in embryonic implantation and placentation. However, the potential mechanism of ROS on porcine trophectoderm (pTr) cell fate during the peri-implantation period has...
Sanne Løkkegaard et al.
NPJ breast cancer, 7(1), 2-2 (2021-01-06)
Resistance to endocrine therapy in estrogen receptor-positive (ER+) breast cancer is a major clinical problem with poorly understood mechanisms. There is an unmet need for prognostic and predictive biomarkers to allow appropriate therapeutic targeting. We evaluated the mechanism by which...
Hsin-Yu Sung et al.
Journal of neurochemistry, 150(6), 691-708 (2019-06-06)
Interleukin-33 (IL-33), a member of the IL1 family, has been found to be expressed in oligodendrocytes (OLGs) and released as an alarmin from injured OLGs to work on other glial cell-types in the central nervous system. However, its functional role...
Luiz Osório Leiria et al.
Cell metabolism, 30(4), 768-783 (2019-07-30)
Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body temperature. Since the role of the lipoxygenase (LOX) family in cold adaptation remains elusive, we aimed to investigate whether...
Heat stress affects some physiological and productive variables and alters metabolism in dairy ewes.
Mehaba, et al.
Journal of Dairy Science, 104, 1099-1110 (2021)
Michael J Kerins et al.
Molecular and cellular biology, 39(13) (2019-04-24)
The nuclear factor (erythroid 2)-like 2 (NRF2 or NFE2L2) transcription factor regulates the expression of many genes that are critical in maintaining cellular homeostasis. Its deregulation has been implicated in many diseases, including cancer and metabolic and neurodegenerative diseases. While...
Felipe Martelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25840-25850 (2020-09-30)
Declining insect population sizes are provoking grave concern around the world as insects play essential roles in food production and ecosystems. Environmental contamination by intense insecticide usage is consistently proposed as a significant contributor, among other threats. Many studies have...
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