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A S Khalid et al.
Irish medical journal, 106(4), 107-110 (2013-05-23)
Recent studies have associated pregnancy loss with subclinical hypothyroidism, defined as elevated thyroid-stimulating-hormone level, with normal free thyroxine. In overt hypothyroidism, the free thyroxine is low. Subclinical and overt hypothyroidism occurs in 0.25-2.5% and 0.2-0.3% of pregnancies respectively. We examined
La-or Chailurkit et al.
European journal of endocrinology, 170(1), 63-67 (2013-10-17)
Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males. To examine whether circulating estradiol (E₂) is related to thyroid autoimmunity in males. One-thousand two-hundred and sixty-three males
Ralph S Grand et al.
Nucleic acids research, 42(20), 12585-12599 (2014-10-25)
Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells
Martina Koeberl et al.
Journal of immunological methods, 415, 6-16 (2014-12-03)
Food allergies are increasing worldwide, demonstrating a considerable public health concern. Shellfish allergy is one of the major food groups causing allergic sensitization among adults and children, affecting up to 2% of the general world population. Tropomyosin (TM) is the
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
M Taillefer et al.
Applied and environmental microbiology, 81(7), 2423-2432 (2015-01-27)
Clostridium thermocellum produces ethanol as one of its major end products from direct fermentation of cellulosic biomass. Therefore, it is viewed as an attractive model for the production of biofuels via consolidated bioprocessing. However, a better understanding of the metabolic
Sonja Heyerdahl et al.
Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
Carla B Schubiger et al.
Applied and environmental microbiology, 81(2), 658-665 (2014-11-09)
Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F.
Lydia-Ann Harris et al.
Nucleic acids research, 42(22), 14053-14059 (2014-11-29)
The DNA sequence preferences of nearly all sequence specific DNA binding proteins are influenced by the identities of bases that are not directly contacted by protein. Discrimination between non-contacted base sequences is commonly based on the differential abilities of DNA
Melissa M L Wong et al.
PloS one, 10(3), e0122025-e0122025 (2015-03-31)
Lentil (Lens culinaris ssp. culinaris) is a nutritious and affordable pulse with an ancient crop domestication history. The genus Lens consists of seven taxa, however, there are many discrepancies in the taxon and gene pool classification of lentil and its
Jérôme Gouge et al.
The EMBO journal, 34(8), 1126-1142 (2015-03-13)
Eukaryotic DNA polymerase mu of the PolX family can promote the association of the two 3'-protruding ends of a DNA double-strand break (DSB) being repaired (DNA synapsis) even in the absence of the core non-homologous end-joining (NHEJ) machinery. Here, we
Xuan Zhuang et al.
Scientific reports, 5, 7922-7922 (2015-01-30)
The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus impaired spermatogenesis. The expression of mRNAs and miRNAs in testicular tissues obtained
Jin Duan et al.
FEMS microbiology letters, 361(2), 181-189 (2014-10-21)
Bacteria often have multiple copies of ribosomal RNA (rrn) genes in their genomes. The presence of multiple rrn operons suggests an advantage to the organism, perhaps through adjustable control of protein expression in response to altered environmental conditions. In the
Pradeepraj Durairaj et al.
Enzyme and microbial technology, 70, 58-65 (2015-02-11)
FoCYP53A19, a novel cytochrome P450 capable of performing benzoate hydroxylation, was identified and characterized from the ascomycete Fusarium oxysporum f.sp. lycopersici. Comparative functional analysis of FoCYP53A19 with the heterologous and homologous cytochrome P450 reductases (CPR) such as Saccharomyces cerevisiae (ScCPR)
Levothyroxine dose and measurement of TSH.
Prasanna Santhanam
The American journal of medicine, 128(1), e13-e13 (2015-01-03)
Pharmacotherapy: Levothyroxine in the elderly-finding the breaking point.
Linda Koch
Nature reviews. Endocrinology, 7(8), 435-435 (2011-06-15)
Xiao-Long Zhou et al.
Nucleic acids research, 42(22), 13873-13886 (2014-11-22)
Yeast mitochondria contain a minimalist threonyl-tRNA synthetase (ThrRS) composed only of the catalytic core and tRNA binding domain but lacking the entire editing domain. Besides the usual tRNA(Thr)2, some budding yeasts, such as Saccharomyces cerevisiae, also contain a non-canonical tRNA(Thr)1
Images in clinical medicine. Myxedema.
Joyce Kim
The New England journal of medicine, 372(8), 764-764 (2015-02-19)
Longfei Yang et al.
Drug design, development and therapy, 9, 1319-1330 (2015-03-15)
Breast cancer is considered to be the most common malignancy in women. Treatment of breast cancer has been focused on molecular targeted therapy, and anticancer peptides are considered to be some of the most promising candidate drugs. In the current
Yacong Zhao et al.
International immunopharmacology, 24(2), 219-223 (2014-12-24)
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders. BLyS binding peptides and their Fc fusion proteins may be alternative BLyS antagonists in such application. In this study, the activity of BLyS binding peptide 814 obtained
Inga Mertens-Walker et al.
Experimental cell research, 333(1), 105-115 (2015-03-01)
The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of
Chris C-S Hsiung et al.
Genome research, 25(2), 213-225 (2014-11-06)
Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors
Héctor F Escobar-Morreale et al.
The Journal of clinical endocrinology and metabolism, 90(8), 4946-4954 (2005-06-02)
Combined infusion of levothyroxine plus liothyronine, as opposed to levothyroxine alone, is the only way of restoring the concentrations of circulating TSH, T4, and T3 as well as those of both T4 and T3 in all tissues of thyroidectomized rats.
Rachel A Okrent et al.
Microbiology (Reading, England), 160(Pt 11), 2432-2442 (2014-08-29)
Pseudomonas fluorescens WH6 secretes a germination-arrest factor (GAF) that we have identified previously as 4-formylaminooxyvinylglycine. GAF irreversibly inhibits germination of the seeds of numerous grassy weeds and selectively inhibits growth of the bacterial plant pathogen Erwinia amylovora. WH6-3, a mutant
Sofie Bliddal et al.
European journal of endocrinology, 170(2), 329-339 (2013-11-28)
Correct interpretation of thyroid status during pregnancy is vital to secure fetal development. Pregnancy-related changes in maternal thyroid status necessitate the use of gestational age-specific reference ranges. In this study, we investigated between-laboratory reproducibility of thyroid reference ranges in pregnant
Arthur Constant Zébré et al.
Journal of bacteriology, 197(9), 1559-1572 (2015-02-19)
Listeriae take up glucose and mannose predominantly through a mannose class phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS(Man)), whose three components are encoded by the manLMN genes. The expression of these genes is controlled by ManR, a LevR-type transcription activator containing two PTS
Annenienke C van de Ven et al.
European journal of endocrinology, 171(2), 183-191 (2014-05-08)
The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known
Rajagopal Sudarsan et al.
Parasitology international, 64(1), 43-49 (2014-10-05)
In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a
Gabriele Loers et al.
The Biochemical journal, 460(3), 437-446 (2014-03-29)
Lack of permissive mechanisms and abundance of inhibitory molecules in the lesioned central nervous system of adult mammals contribute to the failure of functional recovery, which leads to severe disabilities in motor functions or pain. Previous studies have indicated that
Filippa Fleetwood et al.
Microbial cell factories, 13, 179-179 (2014-12-31)
Cell display technologies (e.g. bacterial display) are attractive in directed evolution as they provide the option to use flow-cytometric cell sorting for selection from combinatorial libraries. The aim of this study was to engineer and investigate an expression vector system
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