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Miao Guo et al.
Animal reproduction science, 214, 106287-106287 (2020-02-24)
Estrogen receptor alpha (ERα) is a ligand-activated transcription factor that regulates cellular responses to estrogens and transcription processes of target genes. In this study, changes in DNA methylation and histone modifications in the promoter region and Exon 1 of the
Qionghua Zhu et al.
Cell reports, 26(2), 415-428 (2019-01-10)
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-function mutations that tumor-propagating cells exhibit increased Mll1
Min Tu et al.
Cancer letters, 383(2), 272-281 (2016-10-25)
Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect
Yao Xiong et al.
The Journal of steroid biochemistry and molecular biology, 200, 105640-105640 (2020-02-23)
Bisphenol A(BPA) is one of the most widespread endocrine disruptors in the environment and is associated with reproductive diseases. In this study, we focused on the correlation between environmentally relevant levels of BPA exposure and histone modification during endometrial stromal
Bamaprasad Dutta et al.
Molecular & cellular proteomics : MCP, 13(9), 2183-2197 (2014-05-17)
The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including growth and replication, DNA repair and recombination, and oncogenic
Ming-Hong Sun et al.
Ecotoxicology and environmental safety, 198, 110662-110662 (2020-04-28)
2, 2', 4, 4'-Tetrabrominated diphenyl ether (PBDE47) is the most abundant homologues in polybrominated diphenyl ethers (PBDEs) and is used widely in daily life as a brominated flame retardant. It has been shown that PBDE47 has neurotoxicity, thyroid toxicity, and
Zoé Joly-Lopez et al.
Nature plants, 6(2), 119-130 (2020-02-12)
The extent to which sequence variation impacts plant fitness is poorly understood. High-resolution maps detailing the constraint acting on the genome, especially in regulatory sites, would be beneficial as functional annotation of noncoding sequences remains sparse. Here, we present a
Kathy-Ann Secker et al.
Cancers, 12(5) (2020-05-28)
Epigenetic dysregulation plays a pivotal role in mixed-lineage leukemia (MLL) pathogenesis, therefore serving as a suitable therapeutic target. S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in
Grace R Williams et al.
Methods (San Diego, Calif.), 92, 36-50 (2015-07-15)
The type 1 parathyroid hormone receptor (PTH1R) is a key regulator of calcium homeostasis and bone turnover. Here, we employed SILAC-based quantitative mass spectrometry and bioinformatic pathways analysis to examine global changes in protein phosphorylation following short-term stimulation of endogenously
Yicun Wang et al.
Inflammation, 40(2), 414-421 (2016-12-29)
Immune suppression plays critical roles in the development of chronic osteomyelitis, and the mechanisms underlying the development of immune suppression in chronic osteomyelitis have attracted much attention. LAG-3 is an important suppressor of T cell activation, but the role of
Zhichao Zhang et al.
Molecular neurobiology, 57(2), 997-1008 (2019-10-28)
Neural stem/progenitor cells (NSPCs) persist in the mammalian brain throughout life and can be activated in response to the physiological and pathophysiological stimuli. Epigenetic reprogramming of NPSC represents a novel strategy for enhancing the intrinsic potential of the brain to
Michael J Law et al.
G3 (Bethesda, Md.), 7(3), 1001-1010 (2017-02-02)
In the budding yeast
Tanmoy Bhattacharyya et al.
Current biology : CB, 29(6), 1002-1018 (2019-03-12)
Meiotic recombination is required for correct segregation of chromosomes to gametes and to generate genetic diversity. In mice and humans, DNA double-strand breaks (DSBs) are initiated by SPO11 at recombination hotspots activated by PRDM9-catalyzed histone modifications on open chromatin. However
Shizhao Li et al.
Cancer prevention research (Philadelphia, Pa.), 13(5), 449-462 (2020-03-19)
Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary
Rima Matsuyama et al.
Journal of bioscience and bioengineering, 123(3), 382-389 (2016-10-16)
The establishment process of high-producing Chinese hamster ovary (CHO) cells for therapeutic protein production is usually laborious and time consuming because of the low probability of obtaining stable, high-producing clones over a long term. Thus, development of an efficient approach
Xue Zhang et al.
Frontiers in cell and developmental biology, 8, 582715-582715 (2020-11-03)
Microcystin-leucine arginine (MC-LR) is the most toxic cyanotoxin found in water bodies. Microcystins are produced as secondary products of cyanobacteria metabolism. They have a stable structure, and can bioaccumulate in living organisms. Humans and livestock who drink fresh water containing
Adeleye Opejin et al.
Cell reports, 33(8), 108424-108424 (2020-11-26)
Various processes induce and maintain immune tolerance, but effector T cells still arise under minimal perturbations of homeostasis through unclear mechanisms. We report that, contrary to the model postulating primarily tolerogenic mechanisms initiated under homeostatic conditions, effector programming is an integral
Maja Semanjski et al.
Science signaling, 11(547) (2018-09-13)
The bacterial serine-threonine protein kinase HipA promotes multidrug tolerance by phosphorylating the glutamate-tRNA ligase (GltX), leading to a halt in translation, inhibition of growth, and induction of a physiologically dormant state (persistence). The HipA variant HipA7 substantially increases persistence despite
Anastasia Kougioumtzi et al.
PloS one, 9(6), e98404-e98404 (2014-06-05)
Despite the pleiotropic effects of the progesterone receptor in breast cancer, the molecular mechanisms in play remain largely unknown. To gain a global view of the PR-orchestrated networks, we used next-generation sequencing to determine the progestin-regulated transcriptome in T47D breast
Kaori Naganuma et al.
BMC cancer, 14, 988-988 (2014-12-21)
Epigenetic modifications play important roles in the regulation of gene expression determining cellular phenotype as well as various pathologies such as cancer. Although the loss of keratin 13 (KRT13) is reportedly linked to malignant transformation of oral epithelial cells, the
Vivian Tam et al.
eLife, 9 (2021-01-01)
The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and function. We present DIPPER, a deep and comprehensive IVD proteomic resource comprising 94 genome-wide profiles from 17 individuals. To begin with, protein modules defining key directional trends spanning
Wei-Ju Chen et al.
Scientific reports, 7(1), 9411-9411 (2017-08-27)
The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells.
Bhavna Padmanabhan et al.
Infection and immunity, 88(3) (2019-12-11)
Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing vacuole (CCV). To establish this unique niche, C. burnetii requires the Dot/Icm type IV secretion system (T4SS) to translocate a cohort of effector proteins into the
Shangrong Wu et al.
Mechanisms of ageing and development, 171, 1-6 (2018-02-06)
The osteogenic capacities of bone marrow-derived stromal cells (BMSCs) diminish during replicative senescence, and these changes affect the success of therapeutic application of BMSCs. In this study, we sought to explore the molecular mechanisms underlying the osteogenic differentiation capacities that
Mai Thi Nhu Tran et al.
Nature communications, 8(1), 1700-1700 (2017-11-24)
The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages. Here, we show the expression of the first
Alex-Ane Mathieu et al.
Proteomics, 16(23), 3009-3018 (2016-10-01)
Studying cell differentiation and transformation allows a better understanding of the mechanisms involved in the initiation and the evolution of cancer. The role of proteins which participate in these processes is dependent on their location within the cell. Determining the
Yi Ding et al.
Journal of experimental & clinical cancer research : CR, 38(1), 498-498 (2019-12-21)
The MYCN amplification is a defining hallmark of high-risk neuroblastoma. Due to irregular oncogenes orchestration, tumor cells exhibit distinct fatty acid metabolic features from non-tumor cells. However, the function of MYCN in neuroblastoma fatty acid metabolism reprogramming remains unknown. Gas
J H Kleinschmidt et al.
Biophysical journal, 73(5), 2546-2555 (1997-11-25)
The interactions of lysine oligopeptides with dimyristoyl phosphatidylglycerol (DMPG) bilayer membranes were studied using spin-labeled lipids and electron spin resonance spectroscopy. Tetralysine and pentalysine were chosen as models for the basic amino acid clusters found in a variety of cytoplasmic
P Hallenborg et al.
Cell death & disease, 7(6), e2289-e2289 (2016-07-01)
The ubiquitin ligase MDM2 is best known for balancing the activity of the tumor suppressor p53. We have previously shown that MDM2 is vital for adipocyte conversion through controlling Cebpd expression in a p53-independent manner. Here, we show that the
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