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Yu Xi et al.
Journal of pineal research, 67(3), e12596-e12596 (2019-07-25)
Trimethyltin chloride (TMT) is a potent neurotoxin that causes neuroinflammation and neuronal cell death. Melatonin is a well-known anti-inflammatory agent with significant neuroprotective activity. Male C57BL/6J mice were intraperitoneally injected with a single dose of melatonin (10 mg/kg) before exposure to TMT (2.8 mg/kg, ip). Thereafter, the mice received
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Lucio G Costa et al.
Neurotoxicology, 48, 68-76 (2015-03-24)
Polybrominated diphenyl ethers (PBDEs), used for decades as flame retardants, have become widespread environmental contaminants. Exposure is believed to occur primarily through diet and dust, and infants and toddlers have the highest body burden, raising concern for potential developmental neurotoxicity.
Yoni Baert et al.
Biofabrication, 11(3), 035011-035011 (2019-03-29)
In vitro spermatogenesis (IVS) has already been successfully achieved in rodents by organotypic and soft matrix culture systems. However, the former does not allow single cell input, and the latter presents as a simple thick layer in which all cells
Ya-Jing Liu et al.
Neuro endocrinology letters, 34(3), 236-240 (2013-05-21)
Melatonin not only plays an important role in regulating circadian rhythms, but is also involved in antioxidative defense and immunomodulation. Circulating melatonin levels are derived primarily from the pineal gland while other sources of melatonin have also been reported. Recently
Peng Xiao et al.
Journal of cellular physiology, 234(8), 13413-13422 (2019-01-05)
Induction of repeated superovulation with exogenous hormones is widely used in assisted reproductive technology (ART). Though it is generally safe, emerging evidence has indicated that repeated superovulation may compromise oocyte quality. However, few studies have explored how to ameliorate such
Jing-Li Tao et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)
In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists
Artificial light at night: a neglected population health concern of the built environment.
Margaret Grose
Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals, 25(3), 193-195 (2014-12-02)
L Huang et al.
European review for medical and pharmacological sciences, 17(18), 2449-2456 (2013-10-04)
Recently, widespread interest has grown regarding melatonin treatment of hypertension including its cardioprotective effects. Studies in rodents indicate that melatonin plays a role in the pathogenesis of hypertension in rats with metabolic syndrome. Piromelatine, a melatonin agonist, serotonin 5-HT-1A and
Xiaoqi Pan et al.
Oxidative medicine and cellular longevity, 2015, 703709-703709 (2015-07-18)
Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted a protective effect against ACR-induced
Jingli Tao et al.
International journal of molecular sciences, 22(20) (2021-10-24)
In mammalian, the periodic growth and development of ovarian follicles constitutes the physiological basis of female estrus and ovulation. Concomitantly, follicular angiogenesis exerts a pivotal role in the growth of ovarian follicles. Melatonin (N-acetyl-5-methoxytryptamine, Mel), exists in follicle fluid, was
F Chen et al.
Osteoarthritis and cartilage, 28(8), 1121-1132 (2020-05-30)
This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF-κB signaling pathway. Magnetic resonance imaging (MRI), hematoxylin and eosin (H&E) staining and Safranin-O staining were used to measure disc degeneration in rat needle
[Experimental and clinical evidence for anticonvulsant activity of melatonin].
E B Arushanian
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(11), 111-115 (2014-01-31)
Ryan T Oglesby et al.
Magnetic resonance in medicine, 84(5), 2389-2399 (2020-04-18)
The diagnosis of monoamine-related psychiatric disorders is based on the phenomenological evaluation of symptoms and behavior by trained clinicians. The CEST technique can be sensitive to monoamines such as serotonin. This study quantifies the CEST properties of the compounds in
Anup K Srivastava et al.
Biomaterials science, 8(5), 1345-1363 (2020-01-09)
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and localized deposition of cytoplasmic fibrillary inclusions as Lewy bodies in the brain. The aberrant phosphorylation of α-synuclein at serine 129 is the key process
Lauren M Hablitz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(45), 14957-14965 (2015-11-13)
Melatonin supplementation has been used as a therapeutic agent for several diseases, yet little is known about the underlying mechanisms by which melatonin synchronizes circadian rhythms. G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and
Juliana A Faria et al.
American journal of physiology. Endocrinology and metabolism, 305(2), E230-E242 (2013-05-23)
Melatonin can contribute to glucose homeostasis either by decreasing gluconeogenesis or by counteracting insulin resistance in distinct models of obesity. However, the precise mechanism through which melatonin controls glucose homeostasis is not completely understood. Male Wistar rats were administered an
William J Horton et al.
Psychopharmacology, 232(14), 2519-2530 (2015-02-24)
While it is known that tobacco use varies across the 24-h day, the time-of-day effects are poorly understood. Findings from several previous studies indicate a potential role for melatonin in these time-of-day effects; however, the specific underlying mechanisms have not
Yongxiang Yu et al.
International journal of immunopathology and pharmacology, 35, 20587384211036819-20587384211036819 (2021-08-18)
Type 2 diabetes mellitus (T2DM) is commonly accompanied by obesity and non-alcoholic fatty liver disease (NAFLD), yet the mechanism underlying diabetes-related NAFLD is not fully understood. It has been reported that melatonin can regulate glucose and lipid metabolism. This study
Simone Azevedo de Zanette et al.
BMC pharmacology & toxicology, 15, 40-40 (2014-07-24)
Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifying
Tobias Schmid et al.
PLoS genetics, 11(5), e1005236-e1005236 (2015-05-16)
Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background variation on disease
Ludimila M D Seko et al.
Fertility and sterility, 101(1), 154-161 (2013-11-05)
To examine the best evidence available regarding the effect of melatonin supplementation during controlled ovarian stimulation (COS) on the main assisted reproductive technology (ART) outcomes. Systematic review and meta-analysis of randomized clinical trials (RCT). Not applicable. Women undergoing COS for
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Pengfei Zhang et al.
Molecular human reproduction, 26(2), 65-79 (2020-01-17)
Spermatogenesis, an intricate process occurring in the testis, is responsible for ongoing production of spermatozoa and thus the cornerstone of lifelong male fertility. In the testis, spermatogenesis occurs optimally at a temperature 2-4°C lower than that of the core body.
Areen M Khattabi et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 26(7), 1022-1026 (2018-11-13)
The objective of this research was to investigate the effect of polymer length on the in vitro characteristics of thymoquinone-melatonin (TQ-MLT) when loaded into our previously prepared targeted drug delivery system (TDDS). Our system constructed from silica nanoparticles (NPs) and
Shangming Liu et al.
Journal of pineal research, 59(4), 508-517 (2015-10-18)
Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate
Anna Maria Sniecinska-Cooper et al.
Sleep medicine, 16(1), 94-100 (2014-12-03)
A high rate of sleep disturbances has been reported in individuals with Williams syndrome (WS) but the underlying aetiology has yet to be identified. Melatonin and cortisol levels display circadian rhythmicity and are known to affect and regulate sleep/wake patterns.
Chen Liu et al.
Molecular medicine reports, 10(3), 1323-1328 (2014-07-26)
Melatonin, a widespread physiological mediator, has been demonstrated to exhibit a dose‑dependent immunoregulatory effect in vitro and in vivo, including mediating physiological circadian rhythms, neutralizing free radicals and exerting antisenescence actions. In the present study, the efficacy and mechanism of
Silvia Rivara et al.
Journal of medicinal chemistry, 50(26), 6618-6626 (2007-12-07)
A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)amido scaffold, along with preliminary structure-activity relationships (SARs), is presented. MT1 and MT2 receptor binding affinity and intrinsic activity have been modulated by the introduction of different substituents on the
Bagher Farhood et al.
Medicina (Kaunas, Lithuania), 55(8) (2019-08-02)
Background and objectives: Pneumonitis and fibrosis are the most common consequences of lung exposure to a high dose of ionizing radiation during an accidental radiological or nuclear event, and may lead to death, after some months to years. So far
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