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m6770

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Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice.

Chelsea Hepler et al.

eLife, 7 (2018-09-29)

White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-sequencing and FACS to identify and isolate functionally distinct subpopulations

Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.

Alexandros Sountoulidis et al.

PloS one, 7(8), e41460-e41460 (2012-08-24)

Signaling by Bone Morphogenetic Proteins (BMP) has been implicated in early lung development, adult lung homeostasis and tissue-injury repair. However, the precise mechanism of action and the spatio-temporal pattern of BMP-signaling during these processes remains inadequately described. To address this

Directed differentiation of pluripotent stem cells to functional hepatocytes.

Philip Roelandt et al.

Methods in molecular biology (Clifton, N.J.), 997, 141-147 (2013-04-03)

Differentiation of human stem cells to hepatocytes is crucial for industrial applications as well as to develop new therapeutic strategies for liver disease. The protocol described here, using sequentially growth factors known to play a role in liver embryonic development

Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches.

Brendan Evano et al.

Cell reports, 30(10), 3195-3206 (2020-03-12)

Stem cells can be maintained through symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs). How and when these divisions occur in vivo in vertebrates is poorly understood. Here, we developed a clonogenic cell tracing method that demonstrates the asymmetric distribution

Distinct skeletal stem cell types orchestrate long bone skeletogenesis.

Thomas H Ambrosi et al.

eLife, 10 (2021-07-20)

Skeletal stem and progenitor cell populations are crucial for bone physiology. Characterization of these cell types remains restricted to heterogenous bulk populations with limited information on whether they are unique or overlap with previously characterized cell types. Here we show

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.

Philip Roelandt et al.

PloS one, 5(8), e12101-e12101 (2010-08-17)

Stem cell-derived hepatocytes may be an alternative cell source to treat liver diseases or to be used for pharmacological purposes. We developed a protocol that mimics mammalian liver development, to differentiate cells with pluripotent characteristics to hepatocyte-like cells. The protocol

Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells.

Karen Pauwelyn et al.

PloS one, 6(8), e23096-e23096 (2011-08-11)

Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for human (h)ESC. We recently described a four-step protocol to induce hepatocyte-like cells from

Tumor microenvironment-based screening repurposes drugs targeting cancer stem cells and cancer-associated fibroblasts.

Pei-Jung Lee et al.

Theranostics, 11(19), 9667-9686 (2021-10-15)

The tumorous niche may drive the plasticity of heterogeneity and cancer stemness, leading to drug resistance and metastasis, which is the main reason of treatment failure in most cancer patients. The aim of this study was to establish a tumor

Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells.

Tai-Ling Chao et al.

Frontiers in microbiology, 10, 2942-2942 (2020-02-11)

The pulmonary stem/progenitor cells, which could be differentiated into downstream cells to repair tissue damage caused by influenza A virus, have also been shown to be the target cells of influenza virus infection. In this study, mouse pulmonary stem/progenitor cells

Bone marrow mesenchymal stem cell donors with a high body mass index display elevated endoplasmic reticulum stress and are functionally impaired.

Baris Ulum et al.

Journal of cellular physiology, 233(11), 8429-8436 (2018-05-26)

Bone marrow mesenchymal stem cells (BM-MSCs) are promising candidates for regenerative medicine purposes. The effect of obesity on the function of BM-MSCs is currently unknown. Here, we assessed how obesity affects the function of BM-MSCs and the role of endoplasmic

Transplantation of Human umbilical cord mesenchymal stem cells promotes functional recovery after spinal cord injury by blocking the expression of IL-7.

C-S Bao et al.

European review for medical and pharmacological sciences, 22(19), 6436-6447 (2018-10-20)

This research aimed to investigate the therapeutic effects of transplanted human umbilical cord mesenchymal stem cells (hUCMSCs) on spinal cord injury in mice and to explore its molecular mechanism. Spinal cord injury model in C57BL/6J mice was established. On the

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy.

P Rocheteau et al.

Nature communications, 6, 10145-10145 (2015-12-17)

Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by severe infection and is associated with mortality in 60% of cases. Morbidity due to sepsis is

An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.

Jeff Ishibashi et al.

Molecular and cellular biology, 32(12), 2289-2299 (2012-04-05)

Fibroblastic preadipocyte cells are recruited to differentiate into new adipocytes during the formation and hyperplastic growth of white adipose tissue. Peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipogenesis, is expressed at low levels in preadipocytes, and its levels

An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.

Jeff Ishibashi et al.

Molecular and cellular biology, 32(12), 2289-2299 (2012-04-05)

Benzo[a]pyrene induces fibrotic changes and impairs differentiation in lung stem cells.

Yi-Hsin Tseng et al.

Ecotoxicology and environmental safety, 210, 111892-111892 (2021-01-12)

Human activities have generated air pollution, with extremely small particles (PM 2.5, particulate matter less than 2.5 µm in diameter) and liquid droplets, which become a menace to human health. Among the pollutants, polycyclic aromatic hydrocarbons (PAHs), which enhance the risks

Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells.

Gülen Güney-Esken et al.

Stem cell research & therapy, 12(1), 287-287 (2021-05-15)

Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and consequent loss of function of in

Generation of Human iMelanocytes from Induced Pluripotent Stem Cells through a Suspension Culture System.

Li-Ping Liu et al.

STAR protocols, 1(1), 100004-100004 (2020-10-29)

Melanocytes, derived from neural crest cells, are involved in melanin production. This protocol describes a method to generate induced melanocytes (iMelanocytes) from human induced pluripotent stem cells (iPSCs) using a suspension culture system, which considerably improves the differentiation efficiency. The

Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues.

Cécile Coste et al.

PloS one, 12(7), e0177962-e0177962 (2017-07-07)

Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC.

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