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Isolation and Characterization of Novel Cyclotides from Viola hederaceae SOLUTION STRUCTURE AND ANTI-HIV ACTIVITY OF vhl-1, A LEAF-SPECIFIC EXPRESSED CYCLOTIDE
Chen B, et al.
Journal of biological and chemical chronicles, 280(23), 22395-22405 (2005)
Jun Tang et al.
Peptides, 31(8), 1434-1440 (2010-06-29)
Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif. In general, bioactive plant cyclopeptides are
Bin Chen et al.
The Journal of biological chemistry, 280(23), 22395-22405 (2005-04-13)
Based on a newly established sequencing strategy featured by its efficiency, simplicity, and easy manipulation, the sequences of four novel cyclotides (macrocyclic knotted proteins) isolated from an Australian plant Viola hederaceae were determined. The three-dimensional solution structure of V. hederaceae
Kristen Ryan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11250-11258 (2012-08-17)
Mitochondrial oxidative stress and damage have been implicated in the etiology of temporal lobe epilepsy, but whether or not they have a functional impact on mitochondrial processes during epilepsy development (epileptogenesis) is unknown. One consequence of increased steady-state mitochondrial reactive
Dmitri Mouradov et al.
Methods in molecular biology (Clifton, N.J.), 426, 459-474 (2008-06-11)
Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling
Conan K L Wang et al.
Journal of natural products, 71(1), 47-52 (2007-12-18)
Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities, including anti-HIV and insecticidal activities. More than 100 different cyclotides have been isolated from two phylogenetically distant plant families
Aaron G Poth et al.
The Journal of biological chemistry, 287(32), 27033-27046 (2012-06-16)
Cyclotides are a large family of plant peptides that are structurally defined by their cyclic backbone and a trifecta of disulfide bonds, collectively known as the cyclic cystine knot (CCK) motif. Structurally similar cyclotides have been isolated from plants within
Amanda D Gillon et al.
The Plant journal : for cell and molecular biology, 53(3), 505-515 (2007-12-19)
Plant cyclotides are a large family of naturally occurring circular proteins that are produced from linear precursors containing one, two or three cyclotide domains. The mechanism of excision of the cyclotide domains and ligation of the free N- and C-termini
Cristina Pagliano et al.
Photosynthesis research, 108(1), 33-46 (2011-04-14)
We describe a one-step detergent solubilization protocol for isolating a highly active form of Photosystem II (PSII) from Pisum sativum L. Detailed characterization of the preparation showed that the complex was a monomer having no light harvesting proteins attached. This
Domain architecture and biochemical characterization of vertebrate Mcm10
Robertson PD, et al.
Journal of biological and chemical chronicles, 283(6), 3338-3348 (2008)
Jun Yin et al.
British journal of pharmacology, 173(14), 2208-2223 (2016-06-25)
Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half-life (t1/2 ) to a clinically useful range. We developed a novel uncharged and unstructured recombinant polypeptide composed of five amino acids (P
Sofía B Rodríguez et al.
Archives of biochemistry and biophysics, 504(2), 190-196 (2010-09-21)
Peptidylarginine deiminase (PAD), which catalyzes the deimination of the guanidino group from peptidylarginine residues, belongs to a superfamily of guanidino group modifying enzymes that have been shown to produce an S-alkylthiouronium ion intermediate during catalysis. Thiol-directed reagents iodoacetamide and iodoacetate
Isolation and characterization of cytotoxic cyclotides from Viola tricolor
Tang J, et al.
Peptides, 31(8), 1434-1440 (2010)
Diane D Park et al.
Cell chemical biology, 28(4), 567-582 (2020-12-31)
The pleiotropic functions of macrophages in immune defense, tissue repair, and maintenance of tissue homeostasis are supported by the heterogeneity in macrophage sub-populations that differ both in ontogeny and polarization. Although glycans and glycan-binding proteins (GBPs) are integral to macrophage
Hosein Mohimani et al.
Journal of proteome research, 10(10), 4505-4512 (2011-08-20)
Hundreds of ribosomally synthesized cyclopeptides have been isolated from all domains of life, the vast majority having been reported in the last 15 years. Studies of cyclic peptides have highlighted their exceptional potential both as stable drug scaffolds and as
Nan Jia et al.
Scientific reports, 10(1), 5320-5320 (2020-03-27)
Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and glycosphingolipid-glycans from total human lungs, along
Sofía B Rodríguez et al.
Archives of biochemistry and biophysics, 488(1), 14-22 (2009-06-24)
Porphyromonas gingivalis peptidylarginine deiminase (PAD) catalyzes the deimination of peptidylarginine residues of various peptides to produce peptidylcitrulline and ammonia. P. gingivalis is associated with adult-onset periodontitis and cardiovascular disease, and its proliferation depends on secretion of PAD. We have expressed
Patrick D Robertson et al.
The Journal of biological chemistry, 283(6), 3338-3348 (2007-12-11)
Mcm10 plays a key role in initiation and elongation of eukaryotic chromosomal DNA replication. As a first step to better understand the structure and function of vertebrate Mcm10, we have determined the structural architecture of Xenopus laevis Mcm10 (xMcm10) and
Shane M Simonsen et al.
The Plant cell, 17(11), 3176-3189 (2005-10-04)
Cyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds. It had been postulated that they might be an especially large family of host defense agents, but this
Jenny Forshed et al.
Molecular & cellular proteomics : MCP, 10(10), M111-M111 (2011-07-08)
We present a tool to improve quantitative accuracy and precision in mass spectrometry based on shotgun proteomics: protein quantification by peptide quality control, PQPQ. The method is based on the assumption that the quantitative pattern of peptides derived from one
Qiaoping Qin et al.
BMC genomics, 11, 111-111 (2010-02-18)
Cyclotides are a family of circular peptides that exhibit a range of biological activities, including anti-bacterial, cytotoxic, anti-HIV activities, and are proposed to function in plant defence. Their high stability has motivated their development as scaffolds for the stabilisation of
David C Ireland et al.
The Biochemical journal, 400(1), 1-12 (2006-07-29)
Cyclotides are a fascinating family of plant-derived peptides characterized by their head-to-tail cyclized backbone and knotted arrangement of three disulfide bonds. This conserved structural architecture, termed the CCK (cyclic cystine knot), is responsible for their exceptional resistance to thermal, chemical
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