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Jun Takahashi et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 18(2), 208-215 (2012-12-04)
Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18...
Kelly A Brant et al.
American journal of respiratory cell and molecular biology, 49(1), 105-113 (2013-03-26)
Numerous epidemiological studies have linked exposure to particulate matter (PM) air pollution with acute respiratory infection and chronic respiratory and cardiovascular diseases. We have previously shown that soluble nickel (Ni), a common component of PM, alters the release of CXC...
Th Weiss
VASA. Zeitschrift fur Gefasskrankheiten, 32(4), 187-192 (2003-12-26)
Mode of action of prostaglandin E1 in the treatment of peripheral arterial disease. Prostaglandin E1 has been used for the first time in the treatment of peripheral arterial occlusive disease 30 years ago. Although widely used, the exact mechanism of...
Li-Ping Kang et al.
Phytochemistry, 107, 182-189 (2014-08-31)
Sixteen steroidal saponins, including seven previously unreported compounds, were isolated from Tribulus terrestris. The structures of the saponins were established using 1D and 2D NMR spectroscopy, mass spectrometry, and chemical methods. They were identified as: 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-2α,3β,22α,26-tetrol-12-one (terrestrinin C), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin...
Ilaria Lucca et al.
Revue medicale suisse, 8(365), 2327-2330 (2013-01-22)
Obesity concerns more than 200 million people in the world, with an increasing prevalence in western countries. It is closely related to multiple medical conditions, such as diabetes and hypertension. It was recently shown that testosterone deficiency syndrome and erectile...
Tongyun Chen et al.
The Journal of thoracic and cardiovascular surgery, 147(4), 1362-1367 (2013-11-21)
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide and prostaglandin E1 in the treatment of pulmonary hypertension after mitral valve replacement. Sixty patients with postoperative pulmonary hypertension were divided randomly into 3 groups that received saline, prostaglandin...
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated...
Masayuki Hashiguchi et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 124(6), 321-332 (2004-06-01)
To study the effectiveness for the treatment of intermittent claudication (IC) of three drugs with antiplatelet effects, cilostazol, beraprost sodium, and prostaglandin E(1) (PGE(1)), by using a systemic review of literature and a meta-analysis. A search was undertaken for studies...
Yanming Fan et al.
Coronary artery disease, 26(8), 671-677 (2015-08-13)
The aim of this study was to explore whether intravenous administration of liposomal prostaglandin E1 (lipo-PGE1) can reduce the incidence of periprocedural myocardial injury (PMI) in patients with unstable angina undergoing an elective percutaneous coronary intervention (PCI). In this randomized-controlled...
Practical aspects of prostaglandin E1 before and after solid organ transplantation.
H Müller et al.
Advances in experimental medicine and biology, 433, 9-12 (1997-01-01)
Eric S Schiffhauer et al.
American journal of physiology. Lung cellular and molecular physiology, 304(5), L324-L331 (2013-01-15)
Multiple sodium and chloride channels on the apical surface of nasal epithelial cells contribute to periciliary fluid homeostasis, a function that is disrupted in patients with cystic fibrosis (CF). Among these channels is the chloride channel CLCN2, which has been...
Wan-Jung Lu et al.
Platelets, 25(8), 595-602 (2014-01-18)
Hinokitiol (4-isopropyl-tropolone) is a bioactive compound with various pharmacological activities that is found in the wood of cupressaceous plants. Platelet activation plays an important role in thrombogenesis. In our previous study, hinokitiol specifically inhibited collagen-induced platelet aggregation ex vivo and...
Marcello Gomide et al.
The Journal of thoracic and cardiovascular surgery, 146(5), 1146-1151 (2013-10-17)
Preoperative comorbidities (PCMs) are known risk factors for Norwood stage I (NW1). We tested the hypothesis that short-term bilateral pulmonary arterial banding (bPAB) before NW1 could improve the prognosis of these high-risk patients. From January 2006 to October 2011, 17...
Raymond A Costabile et al.
Expert opinion on pharmacotherapy, 9(8), 1421-1429 (2008-05-14)
Erectile dysfunction is a disease affecting millions of men over the age of 40. Alprostadil, a synthetic form of prostaglandin E(1), was introduced almost three decades ago, and is today considered an alternative treatment for erectile dysfunction. The purpose of...
A P Lea et al.
Drugs & aging, 8(1), 56-74 (1996-01-01)
Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised...
Robert C De Lisle
BMC gastroenterology, 12, 156-156 (2012-11-08)
Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion. In a mouse model of the genetic disease cystic fibrosis, we...
Han Wang et al.
The Cochrane database of systematic reviews, (5)(5), CD006872-CD006872 (2010-05-14)
Diabetic kidney disease (DKD) is one of the major chronic microvascular complications in diabetes mellitus, and may progress to end-stage kidney disease (ESKD). There are no definitely effective approaches for preventing, delaying or treating DKD. Small studies have shown that...
Takashi Onoe et al.
Transplantation, 95(12), 1521-1527 (2013-04-20)
Small-for-size syndrome remains the greatest limiting factor of expanding segmental liver transplantation from living donors. Portal hyperperfusion is considered to substantially contribute to small-for-size syndrome. We investigated the impact of continuous portal infusion of prostaglandin E1 (PGE1) on small-for-size grafts...
O Gottschalk et al.
Scandinavian journal of rheumatology, 43(5), 356-363 (2014-05-16)
The use of statins in the prevention and treatment of cardiovascular diseases is well established. Their use as anti-inflammatory and immunomodulatory agents in the treatment of rheumatoid arthritis (RA) has also been investigated, with several clinical and experimental studies indicating...
Leah Armon et al.
Fertility and sterility, 102(3), 885-890 (2014-07-27)
To characterize the nature of the human oocyte-derived chemoattractant. Laboratory in vitro study. Academic research institute. Ten healthy sperm donors. Oocyte-conditioned media from women undergoing IVF treatment because of male factor infertility. Sperm samples were processed by the migration-sedimentation technique. Oocyte-conditioned...
Swimming through the gut: implications of fluid transport on the microbiome.
Sean P Colgan
Digestive diseases and sciences, 58(3), 602-603 (2013-01-31)
Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
Pediatric Cardiology, 37(1), 131-134 (2016)
Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and alteration of Akt phosphorylation.
Yang P, Cartwright C, Chan D, et al.
Molecular Carcinogenesis, 53(7), 566-577 (2014)
Massimo Polito et al.
BJU international, 110(11 Pt C), E954-E957 (2012-10-20)
Study Type--Therapy (outcomes) Level of Evidence 2a. What's known on the subject? and What does the study add? Erectile dysfunction (ED) is a well known implication of radical prostatectomy (RP). Despite the search for technical improvement in the surgical procedure...
Rebecca A Russell et al.
The Annals of thoracic surgery, 96(3), 885-890 (2013-08-07)
Presentation in shock and preoperative infection remain risk factors for neonatal cardiac surgery. This report describes bilateral pulmonary artery banding (bPAB) in ductal-dependent lesions with systemic outflow obstruction as rescue intervention before surgery with cardiopulmonary bypass in these high-risk neonates....
Pierre Costa et al.
Drugs, 72(17), 2243-2254 (2012-11-23)
The global burden of erectile dysfunction (ED) is increasing. It is estimated that 8-19% of men in Europe have ED and that by 2025 the prevalence of ED worldwide will reach 322 million. The gold standard therapy for ED is...
Maryam Doroudi et al.
The Journal of steroid biochemistry and molecular biology, 145, 65-74 (2014-09-30)
1α,25(OH)2D3 regulates osteoblasts and chondrocytes via its membrane-associated receptor, protein disulfide isomerase A3 (Pdia3) in caveolae. 1α,25(OH)2D3 binding to Pdia3 leads to phospholipase-A2 (PLA2)-activating protein (PLAA) activation, stimulating cytosolic PLA2 and resulting in prostaglandin E2 (PGE2) release and PKCα activation...
[Prostaglandin E1: results and perspectives in clinical practice].
N G Guseva
Klinicheskaia meditsina, 79(2), 4-10 (2001-06-23)
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives...
Adalet Demir et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(6), 974-983 (2014-09-05)
Donor to recipient (D/R) matching in lung transplantation (LTx) is usually directed by blood group (identity or compatibility) and predicted total lung capacity (pTLC) based on height and age. Other donor (D) and recipient (R) characteristics such as cytomegalovirus (CMV)...
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