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Xunmin Ji et al.
Toxicology, 334, 22-32 (2015-05-20)
Heavy metals are common environmental toxicants with adverse effects on steroid biosynthesis. The importance of mitochondria has been recognized in cytotoxic mechanism of heavy metals on Leydig cells these years. But it is still poorly known. Our previous study reported...
Rong-Hu Ke et al.
Journal of neuro-oncology, 118(2), 369-376 (2014-04-18)
Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) has been indicated to have a critical role in various tumors. In the study, we aimed to evaluate the LASS2 expression level in prognostic significance and compare it with commonly...
Katarzyna Gajos et al.
Theriogenology, 84(3), 457-466 (2015-05-13)
Mares that fail to become pregnant after repeated breeding, without showing typical signs of clinical endometritis, should be suspected of subclinical endometritis (SE). Contact with infectious agents results in altered synthesis and secretion of inflammatory mediators, including cytokines and arachidonic...
Jaesung Peter Choi et al.
Endocrine-related cancer, 22(5), 687-701 (2015-08-20)
Haploinsufficient inactivating phosphatase and tensin homolog (Pten) mutations cause Cowden syndrome, an autosomal dominant risk genotype for hormone dependent reproductive cancers. As androgen actions mediated via the androgen receptor (AR) supports uterine growth and may modify uterine cancer risk, we...
Libia Pérez-Torres et al.
The Journal of reproduction and development, 61(3), 199-203 (2015-03-06)
The aim of this study was to establish if pre-synchronization would enhance the number of animals cycling prior to conventional breeding at 45 days irrespective of the length of calf separation. Multiparous Bos indicus cows were allotted in four groups...
Carolina Panis et al.
Cancer letters, 357(1), 186-195 (2014-12-02)
Overexpression of human epithelial growth factor receptor 2 (HER2) is a poor prognostic factor in breast cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. Receptor...
Xiu Xu et al.
FEBS letters, 588(9), 1580-1589 (2014-03-19)
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are...
Pablo U Díaz et al.
Theriogenology, 84(7), 1149-1160 (2015-07-19)
Cystic ovarian disease (COD) is a major factor contributing to poor reproductive efficiency of lactating dairy cows. The objective of the present study was to analyze the endocrine profile, growth dynamics, and histologic characteristics of persistent ovarian follicles-cysts developing in...
Hsun-Ming Chang et al.
The Journal of clinical endocrinology and metabolism, 99(10), E1922-E1932 (2014-07-26)
Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin β-subunits (βA, βB, βC, and βE in humans). Although activins A (βAβA), B (βBβB), AB (βAβB), and AC (βAβC) have been demonstrated in...
Progesterone for traumatic brain injury--resisting the sirens' song.
Lee H Schwamm
The New England journal of medicine, 371(26), 2522-2523 (2014-12-11)
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Jennifer R Taube et al.
Human molecular genetics, 23(20), 5464-5478 (2014-06-04)
Alternative splicing of the proteolipid protein 1 gene (PLP1) produces two forms, PLP1 and DM20, due to alternative use of 5' splice sites with the same acceptor site in intron 3. The PLP1 form predominates in central nervous system RNA....
C V Barnwell et al.
Domestic animal endocrinology, 52, 75-81 (2015-04-29)
The hormone progesterone is essential for proper embryonic development. The objective of this study was to examine the relationship between recipient serum concentrations of progesterone, at the time of embryo transfer and at conceptus recovery, on conceptus development from in...
Carla Mulas et al.
Lab on a chip, 20(14), 2580-2591 (2020-06-24)
Combining live imaging with the ability to retrieve individual cells of interest remains a technical challenge. Combining imaging with precise cell retrieval is of particular interest when studying highly dynamic or transient, asynchronous, or heterogeneous cell biological and developmental processes....
Natalie Falkenberg et al.
Oncotarget, 6(10), 8103-8114 (2015-03-24)
miR-221/-222 and components of the urokinase-type plasminogen activator system (uPAS) are associated with metastasis and poor prognosis in breast cancer, including the triple-negative subtype (TNBC). Modification of components of uPAS and involved miRNAs may contribute to targeted therapy for breast...
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional...
Xindong Zhang et al.
BMC bioinformatics, 16, 92-92 (2015-04-19)
Identifying diagnosis and prognosis biomarkers from expression profiling data is of great significance for achieving personalized medicine and designing therapeutic strategy in complex diseases. However, the reproducibility of identified biomarkers across tissues and experiments is still a challenge for this...
Rikke Poulsen et al.
Aquatic toxicology (Amsterdam, Netherlands), 168, 28-37 (2015-10-04)
A 27-day controlled exposure study of adult male African clawed frogs (Xenopus laevis) was conducted to examine the mechanism by which tebuconazole may disrupt steroidogenesis. The fungicide was measured by LC-MS/MS in tank water and in target tissues (adipose, kidney...
Masahiro Kaneko et al.
Biochemical and biophysical research communications, 443(2), 505-510 (2013-12-18)
Nucleoside transport is important for nucleic acid synthesis in cells that cannot synthesize nucleosides de novo, and for entry of many cytotoxic nucleoside analog drugs used in chemotherapy. This study demonstrates that various steroid hormones induce inhibition of nucleoside transport...
Hideyuki Ohzawa et al.
Breast cancer (Tokyo, Japan), 21(5), 563-570 (2012-10-31)
The effectiveness of neoadjuvant chemotherapy is evaluated on the basis of pathological responses and survival outcome, because achievement of a pathological complete response (pCR) is a good predictor of long-term survival. However, few studies have assessed the survival of breast...
Xiao-Huan Liang et al.
The Journal of biological chemistry, 289(34), 23534-23545 (2014-07-12)
Embryo implantation is a highly synchronized process between an activated blastocyst and a receptive uterus. Successful implantation relies on the dynamic interplay of estrogen and progesterone, but the key mediators underlying embryo implantation are not fully understood. Here we show...
Pil H Lee et al.
Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08)
A multiple linear regression QSAR model was developed based on a set of 61 compounds with internally consistent permeability data measured across Franz cell. The data was normalized using a mean permeability value of a reference compound, 3-isobutyl-1-methylxanthine (IBMX). The...
Laura Piccardi et al.
Aviation, space, and environmental medicine, 84(10), 1092-1094 (2013-11-23)
Discordant findings have been reported about the change in pregnant women's cognitive test performance. Visuo-spatial abilities, which are crucial in terrestrial/flight navigation, could be influenced by hormonal variations. A 32-yr-old Italian Air Force pilot underwent a 2-D Mental Rotation Task...
Stefania Taraborrelli
Acta obstetricia et gynecologica Scandinavica, 94 Suppl 161, 8-16 (2015-09-12)
The aim of this article is to review the physiology of progesterone and focus on its physiological actions on tissues such as endometrium, uterus, mammary gland, cardiovascular system, central nervous system and bones. In the last decades, the interest of...
Esteban Grasso et al.
The Journal of endocrinology, 221(1), 121-131 (2014-02-05)
During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction. Vasoactive intestinal peptide (VIP) is produced by trophoblast cells and modulates the maternal...
Arylsulphatase A activity in human endometrial polyps inversely correlates with aging.
U Indraccolo et al.
Minerva ginecologica, 65(3), 361-362 (2013-05-22)
Jee Hyun Kim et al.
Journal of Korean medical science, 29(9), 1266-1270 (2014-09-24)
This prospective study investigated the relationship between anti-Müllerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was...
Ana Cristina S Herrera et al.
Clinical breast cancer, 14(6), 451-459 (2014-08-01)
Recent studies have suggested a regulatory role for some of the metabolites derived from oxidative stress in breast cancer. In this way, cancer-induced oxidative changes could modify the breast environment and potentially trigger systemic responses that may affect disease prognosis and...
Meghan M Morrison et al.
PLoS genetics, 11(7), e1005291-e1005291 (2015-07-02)
Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTORC2 activity in...
Si Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15)
In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other...
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