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PHR1019

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G Xiao et al.
Industrial health, 39(2), 206-210 (2001-05-09)
The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were
Kyra J Barnes et al.
European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)
To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were
Justin A Edward et al.
Biomacromolecules, 13(8), 2483-2489 (2012-08-02)
The ring-opening polymerization of substituted cyclic carbonates with 1-(3,5-bis-trifluoromethyl-phenyl)-3-cyclohexyl-thiourea (TU)/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) organocatalysts afford highly functionalized oligocarbonates. The fluorescent alkaloid quinine can be readily incorporated into the oligocarbonates either by initiation from quinine or by ring-opening polymerization of a quinine-functionalized cyclic
Farhaan Hafeez et al.
Drug development and industrial pharmacy, 40(6), 838-844 (2013-04-23)
Onychomycosis is a common fungal infection of the nail plate and bed that affects up to 14% of the population and can have a substantial impact on the quality of life of those affected. This study compared the onychopharmacokinetics, nail
Epidural administration of methylprednisolone acetate preserved with benzyl alcohol.
C C King et al.
The Annals of pharmacotherapy, 28(1), 59-60 (1994-01-01)
Jinjin Zhang et al.
Inorganic chemistry, 51(24), 13380-13389 (2012-12-12)
A series of alkali metal complexes supported by two bulky tetraphenols were synthesized and characterized. The reactions of α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xylene(para-tetraphenol) with (n)BuLi, sodium, and KSi(NMe(2))(3) gave bimetallic complexes 1, 2, and 3, respectively. Treatments of the α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-m-xylene(meta-tetraphenol) with 2 or 4
Laura A Jones et al.
The Journal of cell biology, 207(4), 499-516 (2014-11-26)
Cytoplasmic dynein 1 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we
V M L Jolliffe et al.
Clinical and experimental dermatology, 37(8), 862-864 (2012-11-23)
Dermatologists may see patients with actual or suspected local anaesthetic (LA) allergy who require an urgent dermatological procedure to be performed without time for formal allergy testing. We report a case of shave biopsy and subsequent excision biopsy of an
Thomas Pöschinger et al.
Investigative radiology, 49(7), 445-456 (2014-03-07)
Dynamic contrast-enhanced (DCE) micro-computed tomography (micro-CT) has emerged as a valuable imaging tool to noninvasively obtain quantitative physiological biomarkers of drug effect in preclinical studies of antiangiogenic compounds. In this study, we explored the ability of DCE micro-CT to assess
M LeBel et al.
Developmental pharmacology and therapeutics, 11(6), 347-356 (1988-01-01)
Reports on fatal benzyl alcohol poisoning in premature neonates implied that the toxicity may be due to larger doses per kilogram than for adults. It has been postulated that the load of benzoic acid (metabolite of benzyl alcohol) may exceed
H Weibel et al.
Acta pharmaceutica Nordica, 3(3), 159-162 (1991-01-01)
Benzyl carbonate esters of dextran with varying degrees of substitution have been synthesized. The kinetics of the hydrolytic cleavage of the carbonate ester bond in aqueous solution within the pH range 0.44-10.46 (37 degrees C) has been investigated. The degradation
Nikki M Magdaong et al.
The journal of physical chemistry. B, 118(38), 11172-11189 (2014-08-30)
Rhodopin, rhodopinal, and their glucoside derivatives are carotenoids that accumulate in different amounts in the photosynthetic bacterium, Rhodoblastus (Rbl.) acidophilus strain 7050, depending on the intensity of the light under which the organism is grown. The different growth conditions also
M Higo et al.
Analytical chemistry, 66(6), 818-823 (1994-03-15)
Inelastic electron tunneling spectroscopy has been used for the detection and characterization of biological compounds in human sweat adsorbed on alumina surfaces. The sweat was collected from students and distributed to aqueous and benzene phases by solvent extraction. Both solutions
Toshiyuki Fukuda et al.
Biological & pharmaceutical bulletin, 26(2), 271-273 (2003-02-11)
Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting
Y Zhu et al.
Neurobiology of disease, 74, 114-125 (2014-12-03)
Spinal cord injury (SCI) leads to formation of a fibrotic scar that is inhibitory to axon regeneration. Recent evidence indicates that the fibrotic scar is formed by perivascular fibroblasts, but the mechanism by which they are recruited to the injury
Aditya M Kunjapur et al.
Journal of the American Chemical Society, 136(33), 11644-11654 (2014-07-31)
Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding alcohols. We report the construction of an Escherichia
C L Froebe et al.
Dermatologica, 181(4), 277-283 (1990-01-01)
The relationship between the in vivo irritation potential of sodium lauryl sulfate (SLS) and linear alkyl benzene sulfonate (LAS) and the ability of these two surfactants to remove lipid from the stratum corneum (SC) in vitro were investigated. Either surfactant
C H Pierce et al.
Scandinavian journal of work, environment & health, 22(2), 112-118 (1996-04-01)
The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely
Roy Bogseth et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1987-1990 (2014-09-25)
Simple alcohols formed protonated acetonitrile adducts containing up to two acetonitrile molecules when analyzed by ESI or APCI in the presence of acetonitrile in the solvent. These acetonitrile adducts underwent dissociation to form a nitrilium ion, also referred to as
Toralf Bork et al.
Biomedical microdevices, 16(5), 779-792 (2014-07-06)
The MedStream Programmable Infusion Pump, an intrathecal pump indicated for the treatment of chronic intractable pain and severe spasticity (CE-mark) or severe spasticity (US), has a highly accurate medication delivery (within 10% of the programmed flow rate) and is certified
Jun Zhang et al.
Journal of pharmaceutical sciences, 104(5), 1592-1600 (2015-02-20)
Protein stability, one of the major concerns for therapeutic protein development, can be optimized during process development by evaluating multiple formulation conditions. This can be a costly and lengthy procedure where different excipients and storage conditions are tested for their
Qiong Liu et al.
Biochimica et biophysica acta, 1828(9), 2111-2120 (2013-05-11)
The ability to adjust cell volume is required for the adaptation to osmotic stress. Plant protoplasts can swell within seconds in response to hypoosmotic shock suggesting that membrane material is released from internal stores. Since the stability of plant membranes
Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form.
Darwish HW, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 169, 50-57 (2016)
Kevin Deplanche et al.
Journal of the Royal Society, Interface, 9(72), 1705-1712 (2012-03-09)
We report a novel biochemical method based on the sacrificial hydrogen strategy to synthesize bimetallic gold (Au)-palladium (Pd) nanoparticles (NPs) with a core/shell configuration. The ability of Escherichia coli cells supplied with H(2) as electron donor to rapidly precipitate Pd(II)
Béatrice Hechler et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 232-243 (2005-03-29)
Our aim was to determine whether the newly described P2X1 antagonist NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt] could selectively antagonize the platelet P2X1 receptor and how it affected platelet function. NF449 inhibited alpha,beta-methyleneadenosine 5'-triphosphate-induced shape change (IC50 = 83 +/- 13
Wenhuai Kang et al.
Journal of food science, 77(10), C1030-C1035 (2012-09-27)
The aroma-active compounds in Chinese bayberry were identified using gas chromatography-olfactometry (GC-O) and GC-mass spectrometry techniques. The volatile compounds were extracted using Liquid-liquid extraction, solvent-assisted flavor evaporation and headspace solid-phase microextraction (HS-SPME), respectively. On the basis of odor intensity, the
Endea J Curry et al.
Dermatitis : contact, atopic, occupational, drug, 16(4), 203-208 (2006-03-16)
Benzyl alcohol is a weak sensitizer found in a wide array of plants and plant products, foods, cosmetics, and medications. Delayed contact dermatitis reactions as well as immediate, urticarial, and systemic reactions have been reported to occur with its use
A A Melikian et al.
Carcinogenesis, 20(4), 719-726 (1999-05-01)
To investigate how various levels of exposure affect the metabolic activation pathways of benzene in humans and to examine the relationship between urinary metabolites and other biological markers, we have developed a sensitive and specific liquid chromatographic-tandem mass spectrometric assay
Megan K Luther et al.
The Journal of antimicrobial chemotherapy, 69(12), 3263-3267 (2014-08-07)
Antimicrobial lock solutions are used for prevention and management of catheter-related bloodstream infections. ML8-X10 (a prototype oil-in-water micro-emulsion based on a novel free fatty acid), vancomycin/heparin and taurolidine/citrate/heparin (Taurolock™-Hep500) lock solutions were tested against biofilm-forming Staphylococcus epidermidis and methicillin-susceptible Staphylococcus
Yuma Morimoto et al.
Inorganic chemistry, 51(18), 10025-10036 (2012-09-08)
The rate of oxidation of 2,5-dimethoxybenzyl alcohol (2,5-(MeO)(2)C(6)H(3)CH(2)OH) by [Fe(IV)(O)(N4Py)](2+) (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) was enhanced significantly in the presence of Sc(OTf)(3) (OTf(-) = trifluoromethanesulfonate) in acetonitrile (e.g., 120-fold acceleration in the presence of Sc(3+)). Such a remarkable enhancement of the
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