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Taliha Öner et al.
Pediatrics, 133(1), e138-e142 (2013-12-25)
Vitamin B12 is involved in the production of adrenaline from noradrenaline. It is the cofactor involved in catecholamine degradation and plays a role in myelin synthesis. The current study aimed to investigate the association between vitamin B12 levels and postural
Determination of cyanocobalamin in multivitamin tablets by multimode high-performance liquid chromatography
Kitprapiumpo N, et al.
Mahidol University Journal of Pharmaceutical Sciences, 381-382 (2011)
Jeongdae Im et al.
Environmental science & technology, 48(22), 13181-13187 (2014-10-21)
The hydrofluoroolefin 2,3,3,3-tetrafluoropropene (HFO-1234yf) has been introduced to replace 1,1,1,2-tetrafluoroethane (HFC-134a) as refrigerant in mobile, including vehicle, air conditioning systems because of its lower global warming potential. HFO-1234yf is volatile at ambient temperatures; however, high production volumes and widespread handling
Brad Hine et al.
Journal of cellular biochemistry, 115(11), 1948-1954 (2014-06-11)
Intestinal uptake of vitamin B12 (hereafter B12) is impaired in a significant proportion of the human population. This impairment is due to inherited or acquired defects in the expression or function of proteins involved in the binding of diet-derived B12
Ontario health technology assessment series, 13(23), 1-45 (2014-01-01)
More than 2.9 million serum vitamin B12 tests were performed in 2010 in Ontario at a cost of $40 million. Vitamin B12 deficiency has been associated with a few neurocognitive disorders. To determine the clinical utility of B12 testing in
Ivan G Pallares et al.
Biochemistry, 53(50), 7969-7982 (2014-11-26)
CobA from Salmonella enterica (SeCobA) is a member of the family of ATP:Co(I)rrinoid adenosyltransferase (ACAT) enzymes that participate in the biosynthesis of adenosylcobalamin by catalyzing the transfer of the adenosyl group from an ATP molecule to a reactive Co(I)rrinoid species
Determination of vitamin B12 in multivitamin tablets by multimode high-performance liquid chromatography
Wongyai S
Journal of Chromatography A, 870(1-2), 217-220 (2000)
Marzia Dolcino et al.
PloS one, 9(5), e97571-e97571 (2014-05-17)
Regular intravenous immunoglobulin treatment is used to replace antibody deficiency in primary immunodeficiency diseases; however the therapeutic effect seems to be related not only to antibody replacement but also to an active role in the modulation of the immune response.
Luciana Hannibal et al.
Clinical chemistry and laboratory medicine, 51(3), 477-488 (2012-12-18)
The causes of cobalamin (B12, Cbl) deficiency are multifactorial. Whether nutritional due to poor dietary intake, or functional due to impairments in absorption or intracellular processing and trafficking events, the major symptoms of Cbl deficiency include megaloblastic anemia, neurological deterioration
Paula Dominguez-Salas et al.
The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)
Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were
Mattias Johansson et al.
Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants
Neelam Chhillar et al.
Annals of Indian Academy of Neurology, 17(3), 308-312 (2014-09-16)
Changes in lifestyle habits such as diet modification or supplementation have been indicated as probable protective factors for a number of chronic conditions including Alzheimer's disease (AD). With this background, we aim to hypothesize that whether C677T polymorphism of methylenetetrahydrofolate
A F Remacha et al.
Annals of hematology, 93(4), 565-569 (2013-09-24)
Plasma holotranscobalamin (holoTC) transports active cobalamin. Decreased levels of holoTC have been considered to be the earliest marker of cobalamin (Cbl) deficiency. In this work, holoTC was evaluated in low or borderline serum Cbl (LB12) and a concordance analysis was
Illuminating the black box of B12 biosynthesis.
Harry A Dailey
Proceedings of the National Academy of Sciences of the United States of America, 110(37), 14823-14824 (2013-08-27)
A Bøyum et al.
Scandinavian journal of immunology, 80(6), 390-397 (2014-10-28)
The homeostatic control of the redox system (the redoxome) in mammalian cells depends upon a large number of interacting molecules, which tend to buffer the electronegativity of cells against oxidants or reductants. Some of these components kill - at high
Reiko Nishihara et al.
The American journal of clinical nutrition, 100(6), 1479-1488 (2014-11-21)
Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood. We hypothesized that excess alcohol consumption might increase risk of colorectal carcinoma with hypomethylation of insulin-like growth factor
Vladimir M Korkhov et al.
Nature structural & molecular biology, 21(12), 1097-1099 (2014-11-18)
The reaction mechanism of BtuCD-F-catalyzed vitamin B12 transport into Escherichia coli is currently unclear. Here we present the structure of the last missing state in the form of AMP-PNP-bound BtuCD, trapped by a disulfide cross-link. Our structural and biochemical data
Alvin Nursalim et al.
Acta medica Indonesiana, 45(2), 150-156 (2013-06-19)
to determine whether the administration of folic acid, vitamin B6 and vitamin B12 would lead to reduction of cardiovascular complication and mortality among CKD patients. a search was conducted on PubMed and Google. The selection of title and abstract was
Matthew A A Grant et al.
The ISME journal, 8(7), 1418-1427 (2014-02-14)
The growth dynamics of populations of interacting species in the aquatic environment is of great importance, both for understanding natural ecosystems and in efforts to cultivate these organisms for industrial purposes. Here we consider a simple two-species system wherein the
Rebecca L Lander et al.
Public health nutrition, 17(9), 1984-1992 (2013-09-07)
To examine the micronutrient status of disadvantaged pre-schoolers from Northeast Brazil, following the introduction of pro-poor policies, by assessing the prevalence of anaemia and micronutrient deficiencies and the role of sociodemographic factors, genetic Hb disorders and parasitic infections. In a
András Jeney
Orvosi hetilap, 154(44), 1754-1758 (2013-10-29)
Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of
Regan L Bailey et al.
The American journal of clinical nutrition, 98(2), 460-467 (2013-06-28)
No consensus exists about which cutoff point should be applied for serum vitamin B-12 (SB-12) concentrations to define vitamin B-12 status in population-based research. The study's aim was to identify whether a change point exists at which the relation between
Inong R Gunanti et al.
The Journal of nutrition, 144(12), 2027-2033 (2014-11-21)
Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however
Common vitamin B complex agents and folic acid: Part I. Cyanocobalamin (vitamin B12) (kaybovite [parenteral]; berubigen; betalin-12; kaybovite-1000; rubramin-pc).
D W Claussen
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 19(6), 221-222 (1996-11-01)
Jack Metz
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 103(12 Suppl 1), 978-981 (2013-12-05)
Reports from some Western countries indicate that mandatory folate food fortification (FFF) has substantially reduced the prevalence of folate deficiency, leading to calls for folate testing following FFF to be limited to specific indications such as macrocytic anaemia. This is
Anthony Mézière et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 69(12), 1576-1585 (2014-07-27)
Cobalamin deficiency is responsible for hematological, neurological, neurocognitive, and neuropsychiatric impairments and is a risk factor for cardiovascular diseases, particularly in the elderly people. In order to determine B12 status in old inpatients, a total number of 14,904 hospitalized patients
Katherine R Heal et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2398-2404 (2014-10-11)
Vitamin B(12) is an essential nutrient for more than half of surveyed marine algae species, but methods for directly measuring this important cofactor in seawater are limited. Current mass spectrometry methods do not quantify all forms of B(12), potentially missing
Pallavi K Choudhary et al.
Journal of bacteriology, 195(22), 5186-5195 (2013-09-17)
The strategic adaptation of prokaryotes in polluted niches involves the efficient regulation of their metabolism. The obligate anaerobe and metabolically versatile Desulfitobacterium hafniense reductively dechlorinates halogenated organic compounds (so-called organohalides). Some D. hafniense strains carry out organohalide respiration (OHR), a
Bhawani Chamlagain et al.
Food chemistry, 166, 630-638 (2014-07-24)
A sensitive and selective method is needed to analyse in situ produced vitamin B12 in plant-based materials, potential new dietary sources of vitamin B12. A UHPLC/UV method was developed and validated for the determination of human active vitamin B12 in
Nikita L van der Zwaluw et al.
Neurology, 83(23), 2158-2166 (2014-11-14)
We investigated the effects of 2-year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels. This multicenter, double-blind, randomized, placebo-controlled trial included 2,919 elderly participants (65 years and older) with Hcy levels
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