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Martin J Kelly et al.
Frontiers in neuroendocrinology, 33(4), 376-387 (2012-08-09)
It is well known that many of the actions of estrogens in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there now exists compelling evidence for membrane estrogen
Baojian Xue et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H191-H198 (2014-05-27)
This study investigated sex differences in the sensitization of angiotensin (ANG) II-induced hypertension and the role of central estrogen and ANG-(1-7) in this process. Male and female rats were implanted for telemetered blood pressure (BP) recording. A subcutaneous subpressor dose
Carla Peluso et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1401-1412 (2015-03-21)
In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or
Renée T Fortner et al.
Cancer research, 74(23), 6958-6967 (2014-10-05)
Pregnancy, parity, and circulating steroid hormone levels are associated with risk of breast cancer, but little is known about hormone concentrations during pregnancy and subsequent breast cancer risk. We evaluated early pregnancy (<140 days gestation) serum estradiol, estrone, progesterone, and
Chelsea Catsburg et al.
Cancer research, 74(12), 3248-3258 (2014-04-24)
Women with benign proliferative breast disease (BPBD) are at increased risk for developing breast cancer. Evidence suggests that accumulation of adipose tissue can influence breast cancer development via hyperinsulinemia, increased estrogen, and/or inflammation. However, there are limited data investigating these
Laura Ballester et al.
Fertility and sterility, 102(6), 1762-1768 (2014-09-23)
To determine optimal conditions for the inclusion of oviductal fluid (OF) in IVF protocols. Experimental prospective study. Mammalian reproduction research laboratory. Oviducts and ovaries from porcine females were collected at a slaughterhouse. A total of 30 oviducts and 1,285 oocytes
Min Cai et al.
Neuroscience letters, 558, 115-119 (2013-11-20)
Estrogen has been shown to have neuroprotective effects in numerous experimental studies involving young and adult animals. However, several clinical trials have found that in aged postmenopausal women who received estrogen replacement therapy, there did not appear to be a
Xuefang Liang et al.
Environmental pollution (Barking, Essex : 1987), 189, 184-193 (2014-04-01)
Assessing protein responses to endocrine disrupting chemicals is critical for understanding the mechanisms of chemical action and for the assessment of hazards. In this study, the response of the liver proteome of male rare minnows (Gobiocypris rarus) treated with 17β-estradiol
Lianguo Chen et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 116-125 (2014-03-04)
This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingredient used in the commercial antifoulant SeaNine 211, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) was employed as
Ayse Gul Kebapcilar et al.
Archives of gynecology and obstetrics, 290(6), 1255-1263 (2014-07-16)
Previous studies suggest that serum IGF-1 is higher in women with polycystic ovary syndrome (PCOS). The ophthalmologic effects of IGF-1 excess have not yet been investigated in women with PCOS. The aim of the current study is to compare the
Lydia M M Vermeer et al.
Experimental neurology, 263, 8-16 (2014-09-30)
Migraine is one of the most common neurological disorders, leading to more than 1% of total disability reported and over 68 million visits to emergency rooms or physician's offices each year in the United States. Three times as many women
J Stebbing et al.
Oncogene, 34(16), 2103-2114 (2014-06-10)
Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrate for the first time it functions as a tumor suppressor
Jia-Yih Feng et al.
PloS one, 9(6), e97967-e97967 (2014-06-07)
Sex hormones have diverse immunomodulatory effects that may be involved in the pathogenesis of sepsis. However, the roles of serum sex hormones in predicting outcomes and the severity of organ dysfunction, especially acute kidney injury (AKI), in septic shock patients
Yuji Narukawa et al.
Journal of natural medicines, 69(1), 130-134 (2014-09-17)
Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone
Bong-Wook Park et al.
Stem cells and development, 23(14), 1647-1658 (2014-03-07)
Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells
Shuuji Mawaribuchi et al.
Endocrinology, 155(10), 3996-4005 (2014-07-23)
The African clawed frog, Xenopus laevis, has a ZZ/ZW-type sex-determination system. We previously reported that a W-linked gene, Dm-W, can determine development as a female. However, the mechanisms of early sex differentiation remain unclear. We used microarrays to screen for
Lina E Aguirre et al.
International journal of endocrinology, 2014, 507395-507395 (2014-08-29)
In this study, we evaluated the independent and combined effects of baseline circulating gonadal, anabolic hormones and adipokines on physical function in 107 frail, obese (BMI ≥ 30 kg/m(2)), and older (≥65 yr) subjects. Our results showed significant positive correlations between circulating
Yee-Ming Chan et al.
The Journal of clinical endocrinology and metabolism, 99(12), E2762-E2771 (2014-09-17)
Idiopathic hypogonadotropic hypogonadism (IHH) results from defective synthesis, secretion, or action of GnRH. Kisspeptin is a potent stimulus for GnRH secretion. We probed the functional capacity of the GnRH neuronal network in patients with IHH. Eleven subjects with congenital IHH
Sébastien Fournier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(7), R659-R667 (2015-02-06)
Human and animal studies on sleep-disordered breathing and respiratory regulation show that the effects of sex hormones are heterogeneous. Because neonatal stress results in sex-specific disruption of the respiratory control in adult rats, we postulate that it might affect respiratory
Mariana Nigro et al.
Endocrinology, 155(8), 2881-2891 (2014-06-11)
Menopause is associated with increased visceral adiposity and disrupted glucose homeostasis, but the underlying molecular mechanisms related to these metabolic changes are still elusive. Brown adipose tissue (BAT) plays a key role in energy expenditure that may be regulated by
Sherry A Ferguson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 374-392 (2014-05-07)
The developing central nervous system may be particularly sensitive to bisphenol A (BPA)-induced alterations. Here, pregnant Sprague Dawley rats (n = 11-12/group) were gavaged daily with vehicle, 2.5 or 25.0 μg/kg BPA, or 5.0 or 10.0 μg/kg ethinyl estradiol (EE2)
Xiaoyong Fu et al.
Breast cancer research : BCR, 16(5), 430-430 (2014-09-13)
Activation of the phosphatidylinositol 3-kinase (PI3K) pathway in estrogen receptor α (ER)-positive breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. Phosphatase and tensin homolog (PTEN), a negative regulator of this pathway, is
Meiyan Sun et al.
Endocrinology, 155(8), 2787-2796 (2014-05-16)
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and
Zhonghua Shi et al.
Endocrinology, 155(5), 1982-1990 (2014-03-08)
Omental adipose tissue plays a central role in insulin resistance in gestational diabetes mellitus (GDM), and the molecular mechanisms leading to GDM remains vague. Evidence demonstrates that maternal hormones, such as estradiol, contribute to insulin resistance in GDM. In this
Andrea S Fung et al.
BMC cancer, 15, 112-112 (2015-04-18)
The growth of solid tumors and their regrowth after treatment is dependent upon functional tumor vasculature. Some chemotherapeutic agents have shown anti-angiogenic properties but there are limited studies of the effect of chemotherapy on tumor vasculature. Here we investigate the
Estrogens and myocardial chymase: new insights into pathological hypertrophy and remodeling.
Jorge E Jalil et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 271-272 (2014-11-19)
Anna Kiyomi et al.
Journal of Cancer, 6(4), 367-376 (2015-03-15)
Aromatase inhibitor use for postmenopausal hormone-sensitive breast cancer patients often results in drug-induced osteoarthropathy, while its accurate mechanism has not been clarified. We investigated the implication of female hormones and several cytokines in osteoarthropathy complicated with aromatase inhibitor treatment, and
Re: gonadal steroids and body composition, strength, and sexual function in men.
Allen D Seftel
The Journal of urology, 191(5), 1351-1353 (2014-04-22)
Wen-Chin Tsai et al.
International journal of cardiology, 176(1), 110-118 (2014-07-20)
Aging and testosterone deficiency contribute to the pathogenesis of atrial fibrillation (AF). We determine the effects of testosterone replacement on the electrophysiology and arrhythmogenesis of pulmonary vein (PV) and left atrium (LA) in aged rabbits. Electrocardiography, heart rate variability, echocardiography
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