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XiPing Zhang et al.
JOP : Journal of the pancreas, 10(1), 8-14 (2009-01-09)
One of the most common complications of acute pancreatitis is acute lung injury, during which intercellular adhesion molecule-1 (ICAM-1) plays an important role by participating in leukocyte adhesion and activation as well as by inducing the "cascade effect" of inflammatory
Emily A Voigt et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(9), 734-747 (2015-05-06)
The spread of acute respiratory viral infections is controlled by type I and III interferon (IFN) signaling. While the mechanisms of type I IFN signaling have been studied in detail, features that distinguish type III IFN signaling remain poorly understood.
T Christopher Aurand et al.
Biotechnology and bioengineering, 113(3), 492-500 (2015-09-16)
Intestinal inflammation has been implicated in a number of diseases, including diabetes, Crohn's disease, and irritable bowel syndrome. Important components of inflammation are interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), which are elevated both on the luminal and submucosal sides
Jean Francois Fonteneau et al.
Journal of immunology (Baltimore, Md. : 1950), 196(1), 64-71 (2015-11-27)
NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II
Perturbation of the T-cell repertoire in patients with unstable angina.
Liuzzo G
Circulation, 100, 2135-2139 (1999)
Haridha Shivram et al.
PloS one, 14(9), e0222435-e0222435 (2019-09-13)
Polycomb repressive complex 2 (PRC2) is a chromatin binding complex that represses gene expression by methylating histone H3 at K27 to establish repressed chromatin domains. PRC2 can either regulate genes directly through the methyltransferase activity of its component EZH2 or
CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy.
Li J
BMC Cancer, 16, 15-15 (2016)
Runde Jiang et al.
Annals of translational medicine, 9(20), 1527-1527 (2021-11-19)
Our study aimed to investigate the effect of cancer-targeting gene-virotherapy and cytokine-induced killer (CIK) cell immunotherapy on lung cancer. CIK cells were obtained from peripheral blood mononuclear cells using interferon (IFN)-γ, interleukin (IL)-2, and CD3 monoclonal antibody. The CIK cells
Amanda A Melillo et al.
Journal of bacteriology, 191(20), 6447-6456 (2009-08-18)
Francisella tularensis is an intracellular pathogen whose survival is in part dependent on its ability to resist the microbicidal activity of host-generated reactive oxygen species (ROS) and reactive nitrogen species (RNS). In numerous bacterial pathogens, CuZn-containing superoxide dismutases (SodC) are
Jeong-A Lim et al.
Autophagy, 11(2), 385-402 (2015-03-12)
Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination in this typical LSD. We have found multiple mitochondrial defects
Enikő Szabó et al.
Stem cells and development, 24(18), 2171-2180 (2015-07-15)
When mesenchymal stem cells (MSCs) are used for therapy of immunological pathologies, they get into an inflammatory environment, altering the effectiveness of the treatment. To establish the impact of environmental inflammatory factors on MSCs' immunofunction in the mirror of intrinsic
J M Venner et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(11), 2565-2576 (2014-09-16)
We used expression microarrays to characterize the changes most specific for pure T cell-mediated rejection (TCMR) compared to other diseases including antibody-mediated rejection in 703 human kidney transplant biopsies, using a Discovery Set-Validation Set approach. The expression of thousands of
Data on sulforaphane treatment mediated suppression of autoreactive, inflammatory M1 macrophages.
Pal S and Konkimalla VB
Data in Brief, 7, 1560-1564 (2016)
Role of TLR gene expression and cytokine profiling in the immunopathogenesis of viral hepatitis E.
Majumdar M
Journal of Clinical Virology, 73, 8-13 (2015)
Laura Pérez-Lago et al.
Journal of clinical microbiology, 53(11), 3423-3429 (2015-08-14)
The strains involved in tuberculosis outbreaks are considered highly virulent and transmissible. We analyzed the case of a patient in Madrid, Spain, who was persistently infected over an 8-year period by the same Beijing Mycobacterium tuberculosis strain. The strain was
Audra A Winder et al.
Respiratory research, 10, 96-96 (2009-10-20)
The recognition of microbial molecular patterns via toll-like receptors (TLRs) is critical for mucosal defenses. Using well-differentiated primary cultures of human airway epithelia, we investigated the effects of exposure of the cells to cytokines (TNF-alpha and IFN-gamma) and dexamethasone (dex)
Robert J van Eijkeren et al.
Frontiers in endocrinology, 11, 479-479 (2020-08-28)
The complex direct and indirect interplay between adipocytes and various adipose tissue (AT)-resident immune cells plays an important role in maintaining local and whole-body insulin sensitivity. Adipocytes can directly interact with and activate AT-resident invariant natural killer T (iNKT) cells
Shaowei Wang et al.
Molecular neurodegeneration, 16(1), 26-26 (2021-04-18)
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer's disease (AD), but the mechanisms for this association are not clear. The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is involved in
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
Szabo SJ
Science, 295, 338-342 (2002)
Zhengdong Chen et al.
Biochemical and biophysical research communications, 524(2), 308-316 (2020-01-29)
Atherosclerotic plaque rupture is the major trigger of acute cardiovascular risk events, and manipulation of M1/M2 macrophage homeostasis is an effective strategy for regulating atherosclerotic plaque stability. This study was aimed to illuminate the effects of oleoylethanolamide (OEA) on macrophage
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
Mumberg D
Proceedings of the National Academy of Sciences of the USA, 96, 8633-8638 (1999)
MicroRNA-155-IFN-? Feedback Loop in CD4(+)T Cells of Erosive type Oral Lichen Planus.
Scientific Reports, 5, 16935-16935 (2015)
Xi Feng et al.
Biochemical pharmacology, 168, 214-223 (2019-07-16)
Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel phosphonamidate containing compound was designed, synthesized and evaluated for its inhibitory activity against key dioxygenases in Trp-Kyn pathway, including IDO1, IDO2
Martin S Davey et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3704-3716 (2014-08-29)
The early immune response to microbes is dominated by the recruitment of neutrophils whose primary function is to clear invading pathogens. However, there is emerging evidence that neutrophils play additional effector and regulatory roles. The present study demonstrates that human
Guowu Hu et al.
The Journal of clinical investigation, 118(3), 1186-1197 (2008-02-09)
Autophagy is a process by which cells recycle cytoplasm and defective organelles during stress situations such as nutrient starvation. It can also be used by host cells as an immune defense mechanism to eliminate infectious pathogens. Here we describe the
MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.
Dorner BG
Proceedings of the National Academy of Sciences of the USA, 99, 6181-6186 (2002)
Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection.
Haring JS
Journal of Immunology, 174, 6791-6802 (2005)
Chin Theng Ng et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(7), 513-522 (2015-04-02)
Interferon-gamma (IFN-γ) is known to potentiate the progression of inflammatory diseases, such as inflammatory bowel disease and atherosclerosis. IFN-γ has been found to disrupt the barrier integrity of epithelial and endothelial cell both in vivo and in vitro. However, the
Ying Liu et al.
Biosensors & bioelectronics, 64, 43-50 (2014-09-06)
Inflammatory cytokines are secreted by immune cells in response to infection or injury. Quantification of multiple cytokines in parallel may help with disease diagnosis by illuminating inflammatory pathways related to disease onset and progression. This paper describes development of an
Pia Isomäki et al.
Rheumatology (Oxford, England), 54(6), 1103-1113 (2014-11-20)
Many cytokines involved in RA activate the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways. Therapeutic drugs that inhibit these pathways are being developed for RA. To investigate disease-related alterations in the activity of JAK-STAT pathways in RA, we
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