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Rui Zhou et al.
Oncotarget, 6(42), 44609-44622 (2015-11-21)
Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor that has an extremely poor clinical prognosis. Metastasis is the key event in SCLC progression, but its mechanism has not been fully elucidated. MicroRNAs (miRNAs) have been proven to participate
Orsolya Dömötör et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 27(3), 315-328 (2022-03-05)
Solution speciation and serum protein binding of selected In(III) complexes bearing O,O and O,N donor sets were studied to provide comparative data for In(III) and analogous Ga(III) complexes. Aqueous stability of the In(III) complexes of maltol, deferiprone, 8-hydroxyquinoline (HQ) and
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia
Shamsian BS, et al.
Pediatric Hematology and Oncology, 26(5), 356-362 (2009)
Aileen F Keating et al.
Toxicology and applied pharmacology, 241(2), 127-134 (2009-08-22)
4-vinylcyclohexene diepoxide (VCD) is an ovotoxicant that specifically destroys primordial and small primary follicles in the ovaries of mice and rats. In contrast, 7,12-dimethylbenz[a]anthracene (DMBA) is ovotoxic to all ovarian follicle classes. This study investigated phosphatidylinositol-3 kinase signaling involvement in
Ziqiang Wang et al.
Cellular and molecular life sciences : CMLS, 77(17), 3441-3452 (2019-12-16)
The elevated expression of immune checkpoints by the tumor microenvironment is associated with poor prognosis in several cancers due to the exhaustion of tumor-infiltrating lymphocytes (TILs), and the effective suppression of the expression of these genes is key to reversing
Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence.
Sheldon, et al.
PLoS Pathogens, 16, e1008995-e1008995 (2021)
Austen Terwilliger et al.
Journal of bacteriology, 197(14), 2400-2411 (2015-05-13)
Bacteria sustain an infection by acquiring nutrients from the host to support replication. The host sequesters these nutrients as a growth-restricting strategy, a concept termed "nutritional immunity." Historically, the study of nutritional immunity has centered on iron uptake because many
Tamara Matysiak-Budnik et al.
The Journal of experimental medicine, 205(1), 143-154 (2008-01-02)
Celiac disease (CD) is an enteropathy resulting from an abnormal immune response to gluten-derived peptides in genetically susceptible individuals. This immune response is initiated by intestinal transport of intact peptide 31-49 (p31-49) and 33-mer gliadin peptides through an unknown mechanism.
TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Nutritional issues in the patient with diabetes and foot ulcers
Levin and O'Neal's The Diabetic Foot, 199-217 (2008)
Influence of tobacco smoking on transferrin sialylation during pregnancy in smoking and non-smoking women with iron deficiency
Wrzesniak M, et al.
Environmental Toxicology and Pharmacology, 46, 95-102 (2016)
Anna Huguet Ninou et al.
Cancers, 13(14) (2021-07-25)
Replicative repair of interstrand crosslinks (ICL) generated by platinum chemotherapeutics is orchestrated by the Fanconi anemia (FA) repair pathway to ensure resolution of stalled replication forks and the maintenance of genomic integrity. Here, we identify novel regulation of FA repair
Yingyi Zhang et al.
Cell reports, 36(5), 109481-109481 (2021-08-05)
Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import. Here, we establish Fbf1tm1a/tm1a
Non-invasive in vivo imaging of near infrared-labeled transferrin in breast cancer cells and tumors using fluorescence lifetime FRET
Abe K, et al.
PLoS ONE, 8(11), e80269-e80269 (2013)
A Djeha et al.
British journal of haematology, 80(2), 235-241 (1992-02-01)
The effect of different forms of iron and iron-binding proteins on the proliferative response of human lymphocytes to phytohaemagglutinin (PHA) has been studied. Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but
Xiao-hua Lei et al.
PloS one, 6(11), e26603-e26603 (2011-11-19)
The skin is susceptible to different injuries and diseases. One major obstacle in skin tissue engineering is how to develop functional three-dimensional (3D) substitute for damaged skin. Previous studies have proved a 3D dynamic simulated microgravity (SMG) culture system as
Nasa Sinnott-Armstrong et al.
Cell metabolism, 33(3), 615-628 (2021-01-30)
Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density and glycemic traits and identified a
Binding of [Cr (phen) 3] 3+ to transferrin at extracellular and endosomal pHs: Potential application in photodynamic therapy
Garcia PF, et al.
Biochim. Biophys. Acta Gen. Subj., 1840(9), 2695-2701 (2014)
Shujie Ning et al.
International journal of molecular sciences, 20(7) (2019-04-17)
Previous studies have demonstrated that monochromatic light affects plasma melatonin (MEL) levels, which in turn regulates hepatic insulin-like growth factor I (IGF-I) secretion via the Mel1c receptor. However, the intracellular signaling pathway initiated by Mel1c remains unclear. In this study
Cecilia Cederfur et al.
Glycobiology, 18(5), 384-394 (2008-02-12)
Here we report the first survey of galectins binding to glycoproteins of human serum. Serum was subjected to affinity chromatography using immobilized galectins, and the bound glycoproteins were analyzed by electrophoresis, Western blotting, and mass spectrometry. Galectins-3, -8, and -9
Songbo Xie et al.
Journal of cellular physiology, 234(11), 19833-19841 (2019-07-28)
Mammalian erythrocytes are highly specialized cells that have adapted to lose their nuclei and cellular components during maturation to ensure oxygen delivery. Nuclear extrusion, the most critical event during erythropoiesis, represents an extreme case of asymmetric partitioning that requires a
Jimpi Langthasa et al.
Life science alliance, 4(10) (2021-08-12)
Ovarian cancer metastasizes into peritoneum through dissemination of transformed epithelia as multicellular spheroids. Harvested from the malignant ascites of patients, spheroids exhibit startling features of organization typical to homeostatic glandular tissues: lumen surrounded by smoothly contoured and adhered epithelia. Herein
Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
Known and potential roles of transferrin in iron biology
Bartnikas TB
Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, And Medicine, 25(4), 677-686 (2012)
Baosheng Wang et al.
Biochemical and biophysical research communications, 524(2), 288-294 (2020-01-29)
Successful induction of milk protein synthesis relies on prolactin/STAT5. In mice, both laminin and β1 integrin were necessary for STAT5 activity induced by prolactin treatment, resulting in transcriptional activation of β-casein. However, the mechanism by which β1 integrin increases the
Deon G Uffort et al.
The Journal of investigative dermatology, 129(1), 148-154 (2008-08-01)
Tumor expression of inducible nitric oxide synthase (iNOS) predicts poor outcomes for melanoma patients. We have reported the regulation of melanoma iNOS by the mitogen-activated protein kinase (MAPK) pathway. In this study, we test the hypothesis that NF-kappaB mediates this
Dongmei Sun et al.
Molecular and cellular biochemistry, 401(1-2), 21-26 (2014-12-03)
L-Sox5 is a member of sex-determining region Y-type high mobility group box (SOX) family of transcription factors. We assessed the effects of retroviral overexpression of L-Sox5 on chondrocyte differentiation using the clonal murine cell line ATDC5. We observed a temporal-restricted
Large scale screening and identification of novel Ebolavirus and Marburgvirus entry inhibitors
Anantpadma M, et al.
Antimicrobial Agents and Chemotherapy, AAC-00543 (2016)
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