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Vito Guagnano et al.
Cancer discovery, 2(12), 1118-1133 (2012-09-25)
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel
Karen Schindler et al.
Biology of reproduction, 80(4), 795-803 (2009-01-09)
Meiotic maturation in oocytes is a prolonged process that is unique because of cell cycle arrests at prophase of meiosis I (MI) and at metaphase of meiosis II (MII). Fluctuations in cyclin-dependent kinase 1 (CDK1/CDC2A) activity govern meiotic progression, yet
Junko Nakazawa et al.
Chemistry & biology, 10(2), 131-137 (2003-03-06)
To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as
Xiaoqing Chen et al.
Diabetes, 71(4), 795-811 (2022-01-20)
Methazolamide (MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit cardiomyocyte hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes and diabetic db/db mice. However, whether MTZ has a cardioprotective effect in the setting of diabetic
S Cherradi et al.
Journal of experimental & clinical cancer research : CR, 36(1), 89-89 (2017-07-01)
Metastatic colorectal cancer (mCRC) is one of the major causes of cancer-related death. Despite the substantial progress in mCRC management, it remains important to identify new therapeutic options and biological markers for personalized medicine. Here, we investigated the expression of
Luc Gailhouste et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(7), 1840-1854 (2018-05-16)
Primary liver tumors are mainly represented by hepatocellular carcinoma (HCC), one of the most aggressive and resistant forms of cancer. Liver tumorigenesis is characterized by an accumulation of epigenetic abnormalities, leading to gene extinction and loss of hepatocyte differentiation. The
Timo Frensing et al.
Vaccine, 29(41), 7125-7129 (2011-06-10)
Influenza B virus infections are mainly restricted to humans, which is partially caused by the inability of influenza B virus NS1 protein to counteract the innate immune response of other species. However, for cell culture-based influenza vaccine production non-human cells
Sonia Guidato et al.
Developmental biology, 310(2), 250-263 (2007-09-04)
The Wnt signaling pathway is tightly regulated by extracellular and intracellular modulators. Wise was isolated as a secreted protein capable of interacting with the Wnt co-receptor LRP6. Studies in Xenopus embryos revealed that Wise either enhances or inhibits the Wnt
Flora Gilde et al.
Acta biomaterialia, 46, 55-67 (2016-09-17)
Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as an insoluble cue physically bound to a
Elizabeth Sloan et al.
PLoS pathogens, 11(7), e1005059-e1005059 (2015-07-23)
Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is
Clara I Marín-Briggiler et al.
Frontiers in cell and developmental biology, 9, 777086-777086 (2021-12-07)
To acquire fertilization competence, mammalian sperm must undergo several biochemical and physiological modifications known as capacitation. Despite its relevance, the metabolic pathways that regulate the capacitation-related events, including the development of hyperactivated motility, are still poorly described. Previous studies from
Jean Albrengues et al.
Nature communications, 6, 10204-10204 (2015-12-17)
Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of cancer cells. Here we unveil that exposure to LIF initiates
Yongjun Fan et al.
The Journal of biological chemistry, 285(10), 7324-7333 (2009-12-19)
The high glucose consumption of tumor cells even in an oxygen-rich environment, referred to as the Warburg effect, has been noted as a nearly universal biochemical characteristic of cancer cells. Targeting the glycolysis pathway has been explored as an anti-cancer
Valentina Cianfanelli et al.
Nature cell biology, 17(1), 20-30 (2014-12-02)
Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the
Lauren Parker Huff et al.
American journal of physiology. Cell physiology, 316(5), C621-C631 (2019-02-07)
Polymerase-δ-interacting protein 2 (Poldip2) controls a wide variety of cellular functions and vascular pathologies. To mediate these effects, Poldip2 interacts with numerous proteins and generates reactive oxygen species via the enzyme NADPH oxidase 4 (Nox4). We have previously shown that
Marie-José Bijlmakers et al.
Scientific reports, 6, 29232-29232 (2016-07-15)
The activity of RING ubiquitin ligases (E3s) depends on an interaction between the RING domain and ubiquitin conjugating enzymes (E2), but posttranslational events or additional structural elements, yet largely undefined, are frequently required to enhance or regulate activity. Here, we
Neha Saxena et al.
Journal of cell science, 131(7) (2018-03-15)
Efficient homing of human mesenchymal stem cells (hMSCs) is likely to be dictated by a combination of physical and chemical factors present in the microenvironment. However, crosstalk between the physical and chemical cues remains incompletely understood. Here, we address this
Sara Koenig McLaughlin et al.
Cancer cell, 24(3), 365-378 (2013-09-14)
RAS genes are commonly mutated in cancer; however, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and ERK. Here, we report that the RasGAP gene, RASAL2, functions as a tumor and metastasis suppressor. RASAL2 is mutated
Wiebke Handke et al.
Journal of immunology (Baltimore, Md. : 1950), 182(5), 2849-2858 (2009-02-24)
Immediately after viral infection, innate responses including expression of IFN-alpha/beta and IFN-stimulated genes (ISGs) are elicited ubiquitously by recruitment of specific pathogen recognition receptors. The velocity to induce IFN-alpha/beta and ISGs in response to an infection is often decisive for
Xiao-Min Zhang et al.
Neuroreport, 30(5), 369-377 (2019-02-12)
Gap junctions (GJs) are novel molecular targets for pain therapeutics due to their pain-promoting function. INI-0602, a new GJ inhibitor, exerts a neuroprotective role, while its role in neuropathic pain is unclear. The objective was to investigate the analgesic role
Bouke J Duijnisveld et al.
Arthritis research & therapy, 13(6), R207-R207 (2011-12-17)
Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of
Inbal Wortzel et al.
iScience, 24(6), 102670-102670 (2021-07-01)
ERK1c is an alternatively spliced isoform of ERK1 that specifically regulates mitotic Golgi fragmentation, which allows division of the Golgi during mitosis. We have previously shown that ERK1c translocates to the Golgi during mitosis where it is activated by a
Lara M Kingeter et al.
BMC biotechnology, 9, 49-49 (2009-05-26)
Confocal microscopy is a widely employed methodology in cellular biology, commonly used for investigating biological organization at the cellular and sub-cellular level. Most basic confocal microscopes are equipped to cleanly discriminate no more than four fluorophores in a given sample
Joseph D Dukes et al.
Molecular biology of the cell, 22(17), 3192-3205 (2011-07-16)
Genetic screens in Drosophila have identified regulators of endocytic trafficking as neoplastic tumor suppressor genes. For example, Drosophila endosomal sorting complex required for transport (ESCRT) mutants lose epithelial polarity and show increased cell proliferation, suggesting that ESCRT proteins could function
Danielle M Paul et al.
The Journal of cell biology, 219(9) (2020-06-02)
Microtubules and filamentous (F-) actin engage in complex interactions to drive many cellular processes from subcellular organization to cell division and migration. This is thought to be largely controlled by proteins that interface between the two structurally distinct cytoskeletal components.
Peter C Goughnour et al.
Journal of extracellular vesicles, 10(1), e12029-e12029 (2021-03-13)
Glycyl-tRNA synthetase 1 (GARS1), a cytosolic enzyme secreted from macrophages, promotes apoptosis in cancer cells. However, the mechanism underlying GARS1 secretion has not been elucidated. Here, we report that GARS1 is secreted through unique extracellular vesicles (EVs) with a hydrodynamic
Nobuhiro Sasai et al.
PloS one, 8(7), e68478-e68478 (2013-08-13)
Cellular senescence is post-mitotic or oncogene-induced events combined with nuclear remodeling. MCAF1 (also known as hAM or ATF7IP), a transcriptional cofactor that is overexpressed in various cancers, functions in gene activation or repression, depending on interacting partners. In this study
Lixin Mi et al.
The Journal of biological chemistry, 283(32), 22136-22146 (2008-06-06)
Isothiocyanates (ITCs) found in cruciferous vegetables, including benzyl-ITC (BITC), phenethyl-ITC (PEITC), and sulforaphane (SFN), inhibit carcinogenesis in animal models and induce apoptosis and cell cycle arrest in various cell types. The biochemical mechanisms of cell growth inhibition by ITCs are
Jae-Wook Lee et al.
International journal of medical sciences, 18(5), 1247-1258 (2021-02-03)
Di-(2-ethylhexyl) phthalate (DEHP) that is one of the most commonly used phthalates in manufacturing plastic wares regulates tumorigenesis. Thymosin beta-4 (TB4), an actin-sequestering protein, has been reported as a novel regulator to form primary cilia that are antenna-like organelles playing
Yosuke Funato et al.
Nature communications, 12(1), 3683-3683 (2021-06-19)
Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is considered essential
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