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Human colon tissue in organ culture: preservation of normal and neoplastic characteristics
Dame MK, et al.
In Vitro Cellular & Developmental Biology. Animal, 46(2), 114-122 (2010)
Katherine A Giles et al.
Clinical epigenetics, 13(1), 37-37 (2021-02-19)
BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF chromatin remodelling complex, with key roles in modulating DNA accessibility. Dysregulation of BRG1 is observed, but functionally uncharacterised, in a wide range of malignancies. We have probed the functions...
Yoshiro Saito et al.
Journal of lipid research, 56(11), 2172-2182 (2015-09-29)
Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting in a complex phenotype. Selenoproteins play a significant role...
Sarah E Conduit et al.
Human molecular genetics, 29(1), 31-48 (2019-10-19)
Polycystic kidney disease (PKD) results in the formation of renal cysts that can impair function leading to renal failure. DNA damage accumulates in renal epithelial cells in PKD, but the molecular mechanisms are unclear and are investigated here. Phosphoinositide 3-kinase...
Stephanie L Yahn et al.
Neurobiology of disease, 134, 104674-104674 (2019-11-16)
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including...
Hitoo Nishi et al.
Molecular and cellular biology, 31(4), 744-755 (2010-12-15)
MicroRNAs (miRNAs), small noncoding RNAs, are negative regulators of gene expression and play important roles in gene regulation in the heart. To examine the role of miRNAs in the expression of the two isoforms of the cardiac myosin heavy chain...
Hormonal regulation of mannan-binding lectin synthesis in hepatocytes
Sorensen CM, et al.
Clinical and Experimental Immunology, 145(1), 173-182 (2006)
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Agostina Nardone et al.
Cytotechnology, 63(1), 67-80 (2010-12-29)
A small subpopulation of stem/progenitor cells can give rise to the diversity of differentiated cells that comprise the bulk of the tumor. Are proliferating cells, within the bulk of tumor, few cells with uncommon features? The cell biological approach provides...
Irene Antolino-Lobo et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1105-1112 (2010-04-15)
Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase...
Sabine Sewing et al.
Molecular therapy. Nucleic acids, 14, 67-79 (2018-12-26)
Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift...
Noemi García-Romero et al.
Cells, 9(6) (2020-06-11)
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common...
Pradnya Gangatirkar et al.
Nature protocols, 2(1), 178-186 (2007-04-03)
This protocol describes an ex vivo three-dimensional coculture system optimized to study the skin regenerative ability of primary human keratinocytes grown at the air-liquid interface on collagen matrices embedded with human dermal fibroblasts. An option for enrichment of keratinocyte stem...
Patricia L Theard et al.
eLife, 9 (2020-09-09)
Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI effectiveness. We...
Ricardo Cruz-Acuña et al.
Journal of cell science, 132(20) (2019-09-29)
Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell-extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D microenvironments. In addition, these fully defined matrices overcome the lot-to-lot variability of naturally derived materials...
Jung-Feng Lin et al.
International journal of molecular sciences, 20(21) (2019-10-28)
Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron is a highly-pure iron source, which reduces...
Shozo Sonoda et al.
Nature protocols, 4(5), 662-673 (2009-04-18)
We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly polarized and functional monolayer. Disruption of the polarized RPE function plays an important role in the pathogenesis...
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts.
Cheng SY
Proceedings of the National Academy of Sciences of the USA, 77(6), 3425-3429 (1980)
Jungwook Paek et al.
ACS nano, 13(7), 7627-7643 (2019-06-14)
The vasculature is an essential component of the circulatory system that plays a vital role in the development, homeostasis, and disease of various organs in the human body. The ability to emulate the architecture and transport function of blood vessels...
Medical Biochemistry, 769-769 (2001)
Enhancer trap method using a green fluorescent protein reporter plasmid for cloning tissue-specific enhancers active in prostate cells.
Fujiko Watt et al.
Methods in molecular medicine, 81, 321-331 (2003-05-03)
Transgenic mice expressing the human growth hormone gene provide a model system to study human growth hormone synthesis and secretion in non-tumor-derived pituitary cells: differential effects of dexamethasone and thyroid hormone
Vakili H, et al.
Molecular and cellular endocrinology, 345(1-2), 48-57 (2011)
Benjamin W Darbro et al.
The Journal of investigative dermatology, 125(3), 499-509 (2005-08-25)
Cellular stasis, also known as telomere-independent senescence, prevents many epithelial cells from becoming immortalized by telomerase alone. As human keratinocytes age in culture, protein levels of the tumor suppressor p16INK4a continue to increase, resulting in growth arrest independent of telomere...
Ana Feliu et al.
Glia, 68(6), 1255-1273 (2020-01-03)
The failure to remyelinate and regenerate is a critical impediment to recovery in multiple sclerosis (MS), resulting in severe dysfunction and disability. The chondroitin sulfate proteoglycans (CSPGs) that accumulate in MS lesions are thought to be linked to the failure...
C M Sørensen et al.
Clinical and experimental immunology, 145(1), 173-182 (2006-06-24)
Activation of the complement system via the plasma protein mannan-binding lectin (MBL) provides a first line of defence against infections. The plasma level of MBL is, in part, determined genetically, but may also be influenced by different hormones in vivo....
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
Sheng Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(8), 1650-1664 (2021-01-17)
Promoting oligodendrocyte (OL) differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector transcription factor 7-like 2 (TCF7l2) was upregulated in MS lesions and had been proposed to inhibit OL differentiation....
Yi Lu et al.
Science translational medicine, 12(554) (2020-07-31)
Oxidative stress is emerging as a crucial contributor to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying the disturbed redox homeostasis in cystic cells remain elusive. Here, we identified the impaired activity of the...
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