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Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
Neumann H, et al.
The Journal of Experimental Medicine, 185(2), 305-316 (1997)
Jennifer K Lee et al.
Arthritis research & therapy, 17, 28-28 (2015-04-18)
The aim of this study was to investigate the effects of thyroid hormones tri-iodothyronine (T3), thyroxine (T4), and parathyroid hormone (PTH) from the parathyroid glands, known to regulate the developing limb and growth plate, on articular cartilage tissue regeneration using...
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Rosanna Pescini Gobert et al.
Molecular and cellular biology, 29(6), 1538-1553 (2009-01-14)
Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendrocyte differentiation, we performed time-dependent, genome-wide...
Zhi-Yang Chang et al.
PloS one, 8(1), e55291-e55291 (2013-02-06)
This study aimed to evaluate the neuroprotective effect of EPO in the presence of N-methyl-d-aspartate (NMDA)-, trophic factor withdrawal (TFW)-, and tumor necrosis factor-alpha (TNF-α)-induced toxicity on total, small, and large retinal ganglion cells (RGCs). Retinal cells from adult rats...
Melisa Herrero et al.
Neuromolecular medicine, 21(3), 303-313 (2019-05-28)
Vanishing white matter (VWM) disease (OMIM#306896) is an autosomal recessive neurodegenerative leukodystrophy caused by hypomorphic mutations in any of the five genes encoding the subunits of eukaryotic translation initiation factor 2B (eIF2B). The disease is manifested by loss of cerebral...
Packiasamy A R Juliet et al.
Journal of neurochemistry, 109(5), 1285-1299 (2009-05-30)
The germinal matrix of human brain gives rise to oligodendrocytes and astrocytes after mid-gestation. Hemorrhage in the germinal matrix of premature infants is associated with suppressed cell proliferation. We hypothesize that soluble blood constituents have an adverse effect on the...
Lina Dagnino et al.
Methods in molecular biology (Clifton, N.J.), 585, 93-105 (2009-11-13)
In this chapter we review protocols for transient transfection of primary keratinocytes. The ability to transfect primary epidermal cells regardless of their differentiation status allows the biochemical and molecular characterization of multiple proteins. We review methods to analyze exogenous protein...
Alberto Siddu et al.
Neurobiology of disease, 145, 105042-105042 (2020-08-18)
A number of publications have reported that cysteamine has significant therapeutic effects on several aspects of Parkinson's disease (PD)-related pathology but none of these studies have evaluated its impact on pathological forms of α-Synuclein (α-Syn), one of the main hallmarks...
Yi-Ying Kuo et al.
Psychoneuroendocrinology, 118, 104712-104712 (2020-06-02)
Obesity, a critical feature in metabolic disorders, is associated with medical depression. Recent evidence reveals that brown adipose tissue (BAT) activity may contribute to mood disorders, Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels regulate BAT sympathetic nerve activity. However, the mechanism...
Hyesook Yoon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(7), 1483-1500 (2020-01-09)
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PAR1), accelerates myelin development. Here we demonstrate that...
Brian A Davies et al.
Molecular biology of the cell, 31(22), 2463-2474 (2020-08-28)
Intercellular communication is critical for organismal homeostasis, and defects can contribute to human disease states. Polarized epithelial cells execute distinct signaling agendas via apical and basolateral surfaces to communicate with different cell types. Small extracellular vesicles (sEVs), including exosomes and...
Shiping Zou et al.
Journal of neurochemistry, 149(1), 98-110 (2019-01-24)
Myelin disruptions are frequently reported in human immunodeficiency virus (HIV)-infected individuals and can occur in the CNS very early in the disease process. Immature oligodendrocytes (OLs) are quite sensitive to toxic increases in [Ca2+ ]i caused by exposure to HIV-1...
Marsel Lino et al.
Molecular metabolism, 39, 101006-101006 (2020-05-04)
Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardiometabolic disease....
Hannah M Wüst et al.
Nucleic acids research, 48(16), 8959-8976 (2020-07-17)
Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann cell development and myelination chromatin...
Ana Mendanha Falcão et al.
Cell reports, 27(4), 1090-1102 (2019-04-25)
Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of...
Cory L Simpson et al.
Cell reports, 34(5), 108689-108689 (2021-02-04)
The epidermis regenerates continually to maintain a protective barrier at the body's surface composed of differentiating keratinocytes. Maturation of this stratified tissue requires that keratinocytes undergo wholesale organelle degradation upon reaching the outermost tissue layers to form compacted, anucleate cells....
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts.
Cheng SY
Proceedings of the National Academy of Sciences of the USA, 77(6), 3425-3429 (1980)
Carmen Escalona-Garrido et al.
Molecular metabolism, 42, 101097-101097 (2020-10-14)
Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance. Brown adipose tissue (BAT), a therapeutic target against obesity, is an insulin target tissue sensitive to inflammation. Therefore, it is necessary to find...
Richard Daneman et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(2), 641-646 (2009-01-09)
Despite the importance of CNS blood vessels, the molecular mechanisms that regulate CNS angiogenesis and blood-brain barrier (BBB) formation are largely unknown. Here we analyze the role of Wnt/beta-catenin signaling in regulating the formation of CNS blood vessels. First, through...
Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State.
Zhang, et al.
Cell Stem Cell, 27, 784-797 (2021)
Medical Biochemistry, 769-769 (2001)
Murray G Blackmore et al.
Molecular and cellular neurosciences, 44(1), 43-54 (2010-02-18)
Neurons in the central nervous system lose their intrinsic capacity for axon regeneration as they mature, and it is widely hypothesized that changes in gene expression are responsible. Testing this hypothesis and identifying the relevant genes has been challenging because...
Pallavi U Mahaddalkar et al.
Nature biotechnology, 38(9), 1061-1072 (2020-04-29)
Methods for differentiating human pluripotent stem cells to pancreatic and liver lineages in vitro have been limited by the inability to identify and isolate distinct endodermal subpopulations specific to these two organs. Here we report that pancreatic and hepatic progenitors...
Josef Oeckl et al.
STAR protocols, 1(3), 100118-100118 (2020-12-31)
Studying brown and brite adipose tissue requires precise and reliable quantification of cellular thermogenesis. This protocol describes the isolation of primary murine pre-adipocytes, differentiation into thermogenic brown and brite adipocytes, and subsequent oxygen consumption analysis. Commonly applied procedures only measure...
Annette Liessem-Schmitz et al.
Journal of molecular neuroscience : MN, 66(2), 229-237 (2018-08-25)
Mitochondrial dysfunctions mark a critical step in many central nervous system (CNS) pathologies, including multiple sclerosis (MS). Such dysfunctions lead to depolarization of mitochondrial membranes and imbalanced redox homeostasis. In this context, reactive oxygen species (ROS) are potentially deleterious but...
Hiroyuki Sanjo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 9480-9497 (2020-06-01)
In vitro mouse spermatogenesis using a classical organ culture method became possible by supplementing basal culture medium with only the product of bovine serum albumin purified by chromatography (AlbuMAX), which indicated that AlbuMAX contained every chemical factor necessary for mouse...
Scott H Randell et al.
Methods in molecular biology (Clifton, N.J.), 742, 285-310 (2011-05-07)
When primary human airway epithelial (hAE) cells are grown in vitro on porous supports at an air-liquid interface (ALI), they recapitulate in vivo morphology and key physiologic processes. These cultures are useful for studying respiratory tract biology and diseases and...
Carmen Grijota-Martínez et al.
PloS one, 15(7), e0236113-e0236113 (2020-07-21)
Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3'-triiodothyronine (T3) and low thyroxine (T4) levels....
Ronel Z Samuel et al.
Acta biomaterialia, 105, 121-130 (2020-01-29)
Previously we developed a fibrin hydrogel (FH) decorated with laminin-111 peptides (L1p-FH) and supports three-dimensional (3D) gland microstructures containing polarized acinar cells. Here we expand on these results and show that co-culture of rat parotid Par-C10 cells with mesenchymal stem...
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