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Long Ding et al.
Molecular medicine reports, 11(6), 4431-4437 (2015-01-31)
Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits important effects on liver regeneration. However, the mechanism underlying these effects remains unclear.
H Lakshmi Devi et al.
Theriogenology, 143, 98-112 (2019-12-22)
The present study documented the expression and functional role of Fibroblast growth factors (FGFs) family and their receptors (Fibroblast growth factor receptor, FGFRs) in placenta (Cotyledon; COT, Caruncle; CAR) during different stages of pregnancy in water buffalo. Samples were collected
Chike F Oguejiofor et al.
Biology of reproduction, 93(4), 100-100 (2015-09-12)
The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear. Here, we investigated whole-transcriptomic gene expression in primary cultures of mixed
Nilufer Cinkilic et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 770, 72-79 (2014-10-26)
The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline
Sian M Henson et al.
European journal of immunology, 45(5), 1441-1451 (2015-02-25)
Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA
Meghan O Blaya et al.
Experimental neurology, 264, 67-81 (2014-12-09)
Transplantation of neural progenitor cells (NPCs) may be a potential treatment strategy for traumatic brain injury (TBI) due to their intrinsic advantages, including the secretion of neurotrophins. Neurotrophins are critical for neuronal survival and repair, but their clinical use is
Martin Alejandro Krasnapolski et al.
Journal of cancer research and clinical oncology, 141(10), 1727-1738 (2015-02-18)
LM38 murine mammary adenocarcinoma model is formed by LM38-LP (myoepithelial and luminal), LM38-HP (luminal) and LM38-D2 (myoepithelial) cell lines. In a previous work, we had shown that LM38-HP and LM38-D2 cell lines are less malignant than the bicellular LM38-LP cell
Aitor Sánchez-Ferrero et al.
Biomaterials, 68, 42-53 (2015-08-13)
Bone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were produced by means of carbodiimide-catalyzed crosslinking with citric acid, a molecule suggested
Shresh Pathak et al.
Immunologic research, 63(1-3), 236-245 (2015-09-24)
Autoimmune inner ear disease (AIED) is a poorly understood disease marked by bilateral, rapidly progressive hearing loss triggered by unknown stimuli, which is corticosteroid responsive in 60 % of patients. Although the mechanism of the disease is not precisely understood, a
Yanis Toledano-Magaña et al.
Molecules (Basel, Switzerland), 20(6), 9929-9948 (2015-06-04)
Four new hydrazones were synthesized by the condensation of the selected hydrazine and the appropriate nitrobenzaldehyde. A complete characterization was done employing 1H- and 13C-NMR, electrochemical techniques and theoretical studies. After the characterization and electrochemical analysis of each compound, amoebicidal
The sensitivity of 5-formylcytosine to doxorubicin regardless of DNA damage
Turkiye Entomoloji Dergisi (Turkish Journal of Entomology), 40 (2016)
Wayne Goh et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 439-446 (2014-09-17)
Triple negative breast cancers (estrogen, progesterone and human epidermal growth factor 2 (HER2) receptor-negative) are among the most aggressive forms of cancers with limited treatment options. Doxorubicin is one of the agents found in many of the current cancer treatment
Cailing Liu et al.
Investigative ophthalmology & visual science, 55(9), 5551-5560 (2014-08-02)
To investigate the role of DJ-1 in Nrf2-regulated antioxidant defense in corneal endothelial cells (CECs) at baseline and in response to ultraviolet A (UV-A)-induced oxidative stress. DJ-1-deficient CECs were obtained by transfection of an immortalized normal human corneal endothelial cell
Lillian Seu et al.
AIDS research and therapy, 11, 27-27 (2014-09-03)
The level (or frequency) of circulating monocyte subpopulations such as classical (CD14(hi)CD16(-)) and non-classical (CD14(dim)CD16(+)) monocytes varies during the course of HIV disease progression and antiretroviral therapy (ART). We hypothesized that such variation and/or differences in the degree to which
M P Ali et al.
Applied microbiology and biotechnology, 99(23), 10261-10269 (2015-08-05)
Baculoviruses have a long history of safe use as specific, environmentally friendly insecticides that provide alternatives to chemical pesticides for controlling insect pests. However, their use has been limited by several factors, particularly their slow pathogenicity. In this study, we
Sanjay Saw et al.
Inflammation, 38(2), 672-682 (2014-07-24)
Protease(s) enhances airway inflammation and allergic cascade. In the present study, effect of a serine protease inhibitor was evaluated in mouse model of airway disease. Mice were sensitized with cockroach extract (CE) or Per a 10 and treated with 4-(2-aminoethyl)
Jung Jin Lim et al.
Scientific reports, 4, 5923-5923 (2014-08-02)
Enrichment of spermatogonial stem cells (SSCs) from the mammalian adult testis faces several limitations owing to their relatively low numbers among many types of advanced germ cells and somatic cells. The aim of the present study was to improve the
Pedro Réu et al.
PloS one, 14(4), e0216251-e0216251 (2019-05-01)
Cell culture is a ubiquitous and flexible research method. However, it heavily relies on plastic consumables generating millions of tonnes of plastic waste yearly. Plastic waste is a major and growing global concern. Here we describe a new cell culture
Song He et al.
Leukemia & lymphoma, 56(7), 2153-2161 (2014-11-05)
Mounting evidence has proved that cellular adhesion confers resistance to chemotherapy in multiple lymphomas. The molecular mechanism underlying cell adhesion-mediated drug resistance (CAM-DR) is, however, poorly understood. In this study, we investigated the expression and biologic function of histamine-releasing factor
Sally-Anne Stephenson et al.
Oncotarget, 6(10), 7554-7569 (2015-04-02)
EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. EphB4 over-production promotes ligand-independent signaling pathways that increase cancer cell viability and stimulate migration and
Carolina Paola García et al.
Stem cell research, 12(2), 400-414 (2014-01-02)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not
Jisun Oh et al.
Journal of medicinal food, 18(4), 421-428 (2015-02-07)
Red ginseng (Panax ginseng C.A. Meyer) is the most widely recognized medicinal herb due to its remedial effects in various disorders, such as cancers, diabetes, and heart problems. In this study, we investigated the anticancer effect of fermented red ginseng
Marcus Klein et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(2), 273-283 (2014-12-07)
Inflammatory processes are associated with compromised metabolism and elimination of drugs in the liver, largely mediated by proinflammatory cytokines, such as interleukin-6. The Hepa-RG cell line is an established surrogate for primary human hepatocytes (PHH) in drug metabolism and toxicity
Nathalie Khoury et al.
International journal of oncology, 45(5), 2117-2127 (2014-09-06)
Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. Recent studies have focused on the mechanism of action of kefir on cancer cells in vitro. The current study aims at examining the
Yoon Ah Sohn et al.
Biomolecules & therapeutics, 23(1), 53-59 (2015-01-17)
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as
Ileabett M Echevarría-Vargas et al.
PloS one, 9(5), e97094-e97094 (2014-05-29)
Cisplatin has been the most accepted drug for the treatment of ovarian cancer for almost 40 years. Although the majority of patients with ovarian cancer respond to front-line platinum combination chemotherapy, many patients will develop cisplatin-resistance disease, which is extremely
Juliana T Y Lee et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(12), 1743-1755 (2015-06-04)
Differences in matrix compositions in human nucleus pulposus (NP) clinical samples demand different cell isolation protocols for optimal results but there is no clear guide about this to date. Sub-optimal protocols may result in low cell yield, limited reliability of
Ji-Ae Shin et al.
Oncotarget, 6(34), 35667-35683 (2015-10-09)
To date, many different chemotherapeutic agents have been widely used as common treatments for oral cancers. However, their therapeutic effects have been disappointing, and these agents may have unwanted side effects. Among the many regulatory factors, overexpression of pro-survival Bcl-2
Sayeed Ur Rehman et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(2), 1237-1244 (2014-10-26)
6-Mercaptopurine (6MP) is a well-known purine antimetabolite used to treat childhood acute lymphoblastic leukemia and other diseases. Cancer cells as compared to normal cells are under increased oxidative stress and show high copper level. These differences between cancer cells and
Jacinta Simasi et al.
Anticancer research, 34(6), 2841-2850 (2014-06-13)
Tyrosine kinase inhibitors (TKI) have emerged as important therapeutic agents for the treatment of several types of cancer including lung cancer. Recent research attempts show that only a small population of cancer patients responds to TKI and furthermore, these patients
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