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Jeongdae Im et al.
Environmental science & technology, 48(22), 13181-13187 (2014-10-21)
The hydrofluoroolefin 2,3,3,3-tetrafluoropropene (HFO-1234yf) has been introduced to replace 1,1,1,2-tetrafluoroethane (HFC-134a) as refrigerant in mobile, including vehicle, air conditioning systems because of its lower global warming potential. HFO-1234yf is volatile at ambient temperatures; however, high production volumes and widespread handling
M Verdú et al.
Journal of animal science, 93(6), 3018-3033 (2015-06-27)
A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting
B X E Desbiolles et al.
Nano letters, 19(9), 6173-6181 (2019-08-20)
Micronanotechnology-based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a considerable challenge. In this study, a novel type of nanopatterned volcano-shaped microelectrode
Azita Hekmatdoost et al.
PloS one, 10(12), e0143569-e0143569 (2015-12-03)
To determine whether 5-methylenetetrahydrofolate (MTHF) is more effective than folic acid supplementation in treatment of recurrent abortion in different MTHFR gene C677T and A1298C polymorphisms. A randomized, double blind, placebo-controlled trial conducted April 2011-September 2014 in recurrent abortion clinics in
Brad Hine et al.
Journal of cellular biochemistry, 115(11), 1948-1954 (2014-06-11)
Intestinal uptake of vitamin B12 (hereafter B12) is impaired in a significant proportion of the human population. This impairment is due to inherited or acquired defects in the expression or function of proteins involved in the binding of diet-derived B12
Bhawani Chamlagain et al.
Food chemistry, 166, 630-638 (2014-07-24)
A sensitive and selective method is needed to analyse in situ produced vitamin B12 in plant-based materials, potential new dietary sources of vitamin B12. A UHPLC/UV method was developed and validated for the determination of human active vitamin B12 in
Taliha Öner et al.
Pediatrics, 133(1), e138-e142 (2013-12-25)
Vitamin B12 is involved in the production of adrenaline from noradrenaline. It is the cofactor involved in catecholamine degradation and plays a role in myelin synthesis. The current study aimed to investigate the association between vitamin B12 levels and postural
Ivan G Pallares et al.
Biochemistry, 53(50), 7969-7982 (2014-11-26)
CobA from Salmonella enterica (SeCobA) is a member of the family of ATP:Co(I)rrinoid adenosyltransferase (ACAT) enzymes that participate in the biosynthesis of adenosylcobalamin by catalyzing the transfer of the adenosyl group from an ATP molecule to a reactive Co(I)rrinoid species
Marzia Dolcino et al.
PloS one, 9(5), e97571-e97571 (2014-05-17)
Regular intravenous immunoglobulin treatment is used to replace antibody deficiency in primary immunodeficiency diseases; however the therapeutic effect seems to be related not only to antibody replacement but also to an active role in the modulation of the immune response.
C M Miller et al.
New Zealand veterinary journal, 63(4), 211-219 (2015-01-16)
To measure the magnitude and variability in production responses to anthelmintic treatments administered to adult ewes around lambing. Ewes carrying twin lambs, from sheep and beef farms (eight in Year 1 and six in Year 2) in the Wairarapa region
Daniela Baldoni et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(6), 829-837 (2015-04-11)
Vitamin B12 (cyanocobalamin, Cbl) is accumulated by rapidly replicating prokaryotic and eukaryotic cells. We investigated the potential of a Tc-99m labelled Cbl derivative ([(99m)Tc]PAMA(4)-Cbl) for targeting infections caused by Escherichia coli and Staphylococcus aureus. In vitro binding assays were followed
Ontario health technology assessment series, 13(23), 1-45 (2014-01-01)
More than 2.9 million serum vitamin B12 tests were performed in 2010 in Ontario at a cost of $40 million. Vitamin B12 deficiency has been associated with a few neurocognitive disorders. To determine the clinical utility of B12 testing in
David Preiss et al.
The lancet. Diabetes & endocrinology, 2(2), 116-124 (2014-03-14)
Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes. We did a single-centre, double-blind, placebo-controlled trial at the Glasgow
Anita Dayaldasani et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 84(1-2), 92-97 (2014-01-01)
Low maternal vitamin B12 status is a risk factor for various adverse pregnancy outcomes. Although vitamin B12 deficiency is not a primary target of newborn screening (NBS) programs, measurements of propionylcarnitine (C3) and its ratios with acetylcarnitine (C3/C2) and palmitoylcarnitine
I Audet et al.
Journal of animal science, 93(1), 147-157 (2014-11-22)
Homocysteine (Hcy), an intermediary sulfur AA, is recognized as a powerful prooxidant with deleterious effects on physiological and immune functions. In piglets, there is an acute 10-fold increase of plasma concentrations of homocysteine (pHcy) during the first 2 wk of
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
Nor A Mohd-Shukri et al.
Nutrients, 7(10), 8431-8443 (2015-10-13)
The health behaviours of pregnant women with very severe obesity are not known, though these women are at high risk of pregnancy complications. We carried out a prospective case-control study including 148 very severely obese (BMI >40 kg/m²) and 93
Paul O Sheridan et al.
Bio-protocol, 10(7), e3575-e3575 (2021-03-05)
Roseburia and Eubacterium species of the human gut microbiota play an important role in the maintaince of human health, partly by producing butyrate, the main energy source of our colonic epithelial cells. However, our knowledge of the biochemistry and physiology
Theodoros Michelakos et al.
Journal of aging and health, 25(4), 589-616 (2013-04-10)
To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece.
Tito Borner et al.
Cell reports, 31(11), 107768-107768 (2020-06-20)
Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a
Stephen D Merrigan et al.
American journal of clinical pathology, 141(5), 702-705 (2014-04-10)
To systematically assess five automated cobalamin assays for intrinsic factor binding antibody (IFBA)-induced interference using pooled serum. Six pools created from IFBA-negative and IFBA-positive serum representing low, normal, and high cobalamin concentrations were analyzed before and after polyethylene glycol (PEG)
Vitamin B12 and pernicious anemia--the dawn of molecular medicine.
H Franklin Bunn
The New England journal of medicine, 370(8), 773-776 (2014-02-21)
Satoru Watanabe et al.
Acta haematologica, 133(1), 83-88 (2014-08-30)
In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). In the present study, peripheral blood T cell subsets, including regulatory T cells (T(reg)s), were examined before and after
Common vitamin B complex agents and folic acid: Part I. Cyanocobalamin (vitamin B12) (kaybovite [parenteral]; berubigen; betalin-12; kaybovite-1000; rubramin-pc).
D W Claussen
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 19(6), 221-222 (1996-11-01)
Mahesh S Desai et al.
Cell, 167(5), 1339-1353 (2016-11-20)
Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic
Dieuwertje E G Kok et al.
Clinical epigenetics, 7, 121-121 (2015-11-17)
Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation
Haibing He et al.
International journal of pharmaceutics, 493(1-2), 451-459 (2015-08-09)
To improve the oral absorption of insulin, a novel carrier of Vitamin B12 (VB12) gel core solid lipid nanopaticles (Gel-Core-SLN, GCSLN) was designed with a gel core, lipid matrix and VB12-coated surface. VB12-stearate was synthesized and characterized by infrared spectroscopy
Akio Nakajima et al.
PloS one, 10(5), e0126582-e0126582 (2015-05-15)
IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients
Luciana Hannibal et al.
Clinical chemistry and laboratory medicine, 51(3), 477-488 (2012-12-18)
The causes of cobalamin (B12, Cbl) deficiency are multifactorial. Whether nutritional due to poor dietary intake, or functional due to impairments in absorption or intracellular processing and trafficking events, the major symptoms of Cbl deficiency include megaloblastic anemia, neurological deterioration
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Koh A, et al.
Cell, 175(4), 947-961 (2018)
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