Supel™ BioSPME 96-Pin Devices were developed to greatly improve upon the speed and simplicity compared with current sample preparation techniques employed for plasma protein binding studies and other free analyte analyses. This new and innovative technology targets the stringent specifications and quality levels needed by bioanalytical laboratories today.
Supel™ BioSPME 96-pin devices were directly compared with rapid equilibrium dialysis as this is often considered the standard approach for plasma protein binding determination. Supel™ BioSPME offers accurate results with a 3x faster workflow, as shown in the data generated from our analysis involving their direct comparison with rapid equilibrium dialysis. The blue lines indicate the protein binding range of values from the literature. And, the compounds shown with star marks are charged at physiological pH.
Supel™ BioSPME 96-pin devices offer many advantages over the rapid equilibrium dialysis workflow. They provide better time savings, sample cleanliness, and a more simplified workflow, while still maintaining the same high standards of accuracy and reproducibility required by the bioanalytical laboratories performing these workflows. For better and detailed results, download our app note comparing Supel™ BioSPME Vs rapid equilibrium dialysis method. In addition, Supel™ BioSPME devices offers the flexibility of using either a fully automated method or manual method, to suit the needs and capabilities of your lab.