FLT3
fms-related tyrosine kinase 3
Sinónimos:
CD135, FLK-2, FLK2, STK1
Especie:
Human FLT3 (2322), Mouse Flt3 (14255), Rat Flt3 (140635), Horse FLT3 (100061780), dog FLT3 (486025), chicken FLT3 (100858422), domestic cat FLT3 (101099264), Domestic Rabbit FLT3 (100342842), Zebrafish flt3 (566708), sheep FLT3 (101112331) ...Más
ID UniProtKB:
ID del gen:
- Human(2322) Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
- Mouse(14255) FMS-like tyrosine kinase 3
- Rat(140635) fms-related tyrosine kinase 3
- Horse(100061780) fms-related tyrosine kinase 3
- dog(486025) fms-related tyrosine kinase 3
- chicken(100858422) fms-related tyrosine kinase 3
- domestic cat(101099264) fms-related tyrosine kinase 3
- Domestic Rabbit(100342842) fms-related tyrosine kinase 3
- Zebrafish(566708) fms-related tyrosine kinase 3
- sheep(101112331) fms-related tyrosine kinase 3
- naked mole-rat(101713724) fms-related tyrosine kinase 3
- cow(512700) fms-related tyrosine kinase 3
- domestic guinea pig(100732047) fms-related tyrosine kinase 3
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ELISA
Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-FLT3 (Ab-591) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
ELISA
western blot
western blot
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunohistochemistry
Anti-FLT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Small Molecule - Inhibitor
Proteins
Número de producto
Descripción
Especie
Flt3 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE),
Especie
human
Flt-3/Flk-2 ligand human, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC),
Especie
human
FLT3 (571-993), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human