Merck
All Photos(1)

275875

Sigma-Aldrich

4-Aminopyridine

≥99%

Synonym(s):
4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine
Empirical Formula (Hill Notation):
C5H6N2
CAS Number:
Molecular Weight:
94.11
Beilstein:
105782
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.22

Nivel de calidad

100

ensayo

≥99%

formulario

solid

bp

273 °C (lit.)

mp

155-158 °C (lit.)

solubilidad

DMF: soluble(lit.)
DMSO: soluble(lit.)
THF: soluble(lit.)
acetone: soluble(lit.)
acetonitrile: soluble(lit.)
ethanol: soluble(lit.)
isopropanol: soluble(lit.)
methanol: soluble(lit.)
water: soluble(lit.)

SMILES string

Nc1ccncc1

InChI

1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChI key

NUKYPUAOHBNCPY-UHFFFAOYSA-N

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Descripción general

4-Aminopyridine (4-AP) blocks the voltage-dependent potassium channels in other nerve membranes[1]. 4-AP is a K+ channel blocker and causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man[2].

Aplicación

4-Aminopyridine can be used as:
  • A reactant to prepare pharmacologically important 4-amino-N-pyridin-4-yl-butyramide hydrochloride.[3]
  • A reactant to prepare cinnamic acid derivatives as potent cholinesterase inhibitors.[4]
  • A starting material to prepare aza analogs of batracylin, a topoisomerase II inhibitor.[5]

Envase

1, 5 g in glass bottle

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Código de clase de almacenamiento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Punto de inflamabilidad F

312.8 °F

Punto de inflamabilidad C

156 °C

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificate of Analysis

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Certificate of Origin

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