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Merck

375160

(S)-(+)-Ibuprofen

ReagentPlus®, 99%

Sinónimos:

S-(+)-IBU, (S)-(+)-2-(4-Isobutylphenyl)propionic acid, (S)-(+)-4-Isobutyl-α-methylphenylacetic acid

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1 G

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5 G

MXP 2,787.00


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Fórmula lineal:
(CH3)2CHCH2C6H4CH(CH3)CO2H
Número CAS:
Peso molecular:
206.28
Beilstein/REAXYS Number:
3590022
MDL number:
UNSPSC Code:
12352002
PubChem Substance ID:
NACRES:
NA.22

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product line

ReagentPlus®

assay

99%

form

powder

optical activity

[α]20/D +59°, c = 2 in ethanol

mp

49-53 °C (lit.)

functional group

carboxylic acid

SMILES string

CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

InChI key

HEFNNWSXXWATRW-JTQLQIEISA-N

Gene Information

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1 of 4

Este artículo
284785I4883I110
assay

99%

assay

98%

assay

≥98% (GC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

powder

form

-

form

powder

form

-

mp

49-53 °C (lit.)

mp

152-154 °C (lit.)

mp

77-78  °C

mp

-

product line

ReagentPlus®

product line

-

product line

-

product line

-

optical activity

[α]20/D +59°, c = 2 in ethanol

optical activity

[α]25/D +66°, c = 1 in chloroform

optical activity

-

optical activity

-

General description

(S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.[1]

Application

(S)-(+)-Ibuprofen may be used as a starting material to synthesize hydrogelators with the potential ability to release it via enzyme-mediated hydrolysis.[2]
Enantiomeric form of the anti-inflammatory agent ibuprofen used in pharmacokinetic studies.[3]

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Clase de almacenamiento

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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(S)-(+)-Ibuprofen-based hydrogelators: an approach toward anti-inflammatory drug delivery.
Bhuniya S, et al.
Tetrahedron Letters, 47(40), 7153-7156 (2006)
Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography-electrospray mass spectrometry.
Bonato PS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 796(2), 413-420 (2003)
Elizabeth R Southey et al.
Current medical research and opinion, 25(9), 2207-2222 (2009-07-18)
The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. MEDLINE (1950 to November 2008), EMBASE (1980 to
Jennifer Manley et al.
The Annals of pharmacotherapy, 41(7), 1227-1232 (2007-05-24)
To evaluate the literature examining prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization. Articles were identified via MEDLINE/PubMed/EMBASE (1966-March 2007) using the following key terms: vaccination, immunization, diphtheria-tetanus toxoids-whole pertussis (DTwP), diphtheria tetanus-toxoid
F Jamali et al.
Journal of pharmaceutical sciences, 81(3), 221-225 (1992-03-01)
The influences of absorption rate and dosage size on the pharmacokinetics of ibuprofen (IB) enantiomers were studied in six healthy subjects. Rapidly absorbed solutions (50, 100, 200, 400, 600, and 1200 mg) and regular 600-mg tablets of racemic IB were

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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