386529

Chlorotrimethylsilane

purified by redistillation, ≥99%

• Sinónimos: Trimethylsilyl chloride, TMSCl, TMCS, Trimethylchlorosilane
• Fórmula lineal: (CH₃)₃SiCl
• Número de CAS: 75-77-4
• Peso molecular: 108.64
• Beilstein: 1209232
• Número de EC: 200-900-5
• Número MDL: MFCD00000502
• ID de la sustancia en PubChem: 24864097
• NACRES: NA.22

Propiedades

• Nivel de calidad: 200
• densidad de vapor: 3.7 (vs air)
• presión de vapor: 100 mmHg ( 25 °C)
• ensayo: ≥99%
• formulario: liquid
• temp. de autoignición: 752 °F
• purificado por: glass distillation; redistillation
• lim. expl.: 6.4 %
• impurezas: <0.1% dichlorodimethylsilane
• índice de refracción: n20/D 1.387 (lit.)
• bp: 57 °C (lit.)
• mp: −40 °C (lit.)
• densidad: 0.856 g/mL at 25 °C (lit.)
• SMILES string: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChI key: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Descripción

Descripción general

Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.

Aplicación

Chlorotrimethylsilane (TMSCl) can be used as:       

• A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.      
• A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.        
• A trapping agent for the anions generated during acyloin condensation reaction.       
• A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
•  A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.        
• A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.       
• A reagent in Fischer glycosidation.       
• A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et₃SiH.
• A reagent to synthesize sodium trimethylsilanethiolate (Me₃SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me₃SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.

Envase

1, 2 L in Sure/Seal™

25, 100, 4×100 mL in Sure/Seal™

Información de seguridad

• pictogramas: GHS02,GHS05,GHS06
• Palabra de señalización: Danger
• Frases de peligro: H225 - H301 + H331 - H312 - H314
• Consejos de prudencia: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Riesgos supl.: EUH014
• Código de clase de almacenamiento: 3 - Flammable liquids
• WGK: WGK 1
• Punto de inflamabilidad F: -18.4 °F - closed cup
• Punto de inflamabilidad C: -28 °C - closed cup
• Equipo de protección personal: Faceshields, Gloves, Goggles