900889

Sigma-Aldrich

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

≥95%

Sinónimos:
LAP
Empirical Formula (Hill Notation):
C16H16LiO3P
Número de CAS:
Peso molecular:
294.21

Quality Level

assay

≥95%

form

crystalline powder

color

white to off-white

storage temp.

2-8°C

SMILES string

CC1=C(C(P(C2=CC=CC=C2)(O[Li])=O)=O)C(C)=CC(C)=C1

Categorías relacionadas

Application

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis

Certificado de origen

Zachary M Geisterfer et al.
STAR protocols, 1(3), 100221-100221 (2020-12-31)
Cell-free extract derived from the eggs of the African clawed frog Xenopus laevis is a well-established model system that has been used historically in bulk aliquots. Here, we describe a microfluidic approach for isolating discrete, biologically relevant volumes of cell-free...
Benjamin D Fairbanks et al.
Biomaterials, 30(35), 6702-6707 (2009-09-29)
Due to mild reaction conditions and temporal and spatial control over material formation, photopolymerization has become a valuable technique for the encapsulation of living cells in three dimensional, hydrated, biomimetic materials. For such applications, 2-hydroxy-1-[4-(2-hydroxyethoxy) phenyl]-2-methyl-1-propanone (I2959) is the most...
Benjamin D Fairbanks et al.
Macromolecules, 44(8), 2444-2450 (2011-04-23)
Various techniques have been adopted to impart a biological responsiveness to synthetic hydrogels for the delivery of therapeutic agents as well as the study and manipulation of biological processes and tissue development. Such techniques and materials include polyelectrolyte gels that...
Andrew C Daly et al.
Nature communications, 12(1), 753-753 (2021-02-04)
Cellular models are needed to study human development and disease in vitro, and to screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of functional tissue models with requisite cell densities and heterogeneity to appropriately model...
Zhiguang Qiao et al.
Biomaterials, 266, 120385-120385 (2020-10-30)
Despite significant advances in osteochondral tissue engineering, it remains challenging to successfully reconstruct native-like complex tissues organized in three-dimension with spatially varying compositional, structural and functional properties. In this contribution, inspired by the gradients in extracellular matrix (ECM) composition and...
Artículos
The introduction of LAP and water-dispersible photoinitiator nanoparticles of TPO, enables the development of novel formulations for 3D bioprinting, tissue engineering applications, and device manufacturing.
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Contenido relacionado
Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.
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