2-Methylnicotinic acid imidazolide

Name: 2-Methylnicotinic acid imidazolide
Brand: ALDRICH
Price: 2108 MXP

Sinónimos:

(1H-imidazol-1-yl)(2-methylpyridin-3-yl)methanone, 1H-Imidazol-1-yl(2-methyl-3-pyridinyl)methanone, 3-(1H-imidazole-1-carbonyl)-2-methylpyridine, NAI, RNA SHAPE probe, RNA structure probe, mNAI

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50 MG

MXP 2,108.00

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MXP 2,108.00

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Fórmula empírica (notación de Hill):

C₁₀H₉N₃O

Número CAS:

1055970-47-2

Peso molecular:

187.20

UNSPSC Code:

12352106

NACRES:

NA.22

MDL number:

MFCD25954959

Form:

powder

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SMILES string

[n]2(cncc2)C(=O)c1c(nccc1)C

InChI

1S/C10H9N3O/c1-8-9(3-2-4-12-8)10(14)13-6-5-11-7-13/h2-7H,1H3

InChI key

OWQPEDNXDCVXJO-UHFFFAOYSA-N

form

powder

mp

68-72 °C

storage temp.

2-8°C

Quality Level

100

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Este artículo	719501	SML2440	1411038
Sigma-Aldrich 913839 2-Methylnicotinic acid imidazolide	Sigma-Aldrich 719501 N-Methyl-4-(tributylstannyl)imidazole	Sigma-Aldrich SML2440 SGC-iMLLT	USP 1411038 Methimazole Related Compound C
Quality Level 100	Quality Level 100	Quality Level -	Quality Level -
form powder	form liquid	form powder	form -
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C
mp 68-72 °C	mp -	mp -	mp -

Application

2-Methylnicotinic acid imidazolide (NAI or mNAI) is an RNA SHAPE probe for live-cell RNA structure profiling. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes to react with the 2′-hydroxyl group and provides insight to RNA structure and its dynamics in varied cells states or in cells with gene knockouts. It has also been extended to the SHALiPE approach, selective 2′-hydroxyl acylation with lithium ion-based primer extension.

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies

SnapShot: RNA Structure Probing Technologies

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

Determination of in vivo RNA structure in low-abundance transcripts

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Referencia del producto

Descripción

Precios

115959

Benzoyl cyanide, 98%

320293

Dimethyl sulfate, ≥99%

03-310

In Vivo SHAPE Reagent for Live Cell RNA Structure Analysis, permits the analysis of RNA structure in living cells

908401

1-Methyl-7-nitroisatoic anhydride

913812

2-(Azidomethyl)nicotinic acid imidazolide, ≥95%

914487

2-(Diphenylphosphanyl)benzamide, ≥95%

914983

ThT-NE, ≥95%

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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RNA SHAPE analysis in living cells.

Robert C Spitale et al.

Nature chemical biology, 9(1), 18-20 (2012-11-28)

RNA structure has important roles in practically every facet of gene regulation, but the paucity of in vivo structural probes limits current understanding. Here we design, synthesize and demonstrate two new chemical probes that enable selective 2'-hydroxyl acylation analyzed by

Conditional control of RNA-guided nucleic acid cleavage and gene editing.

Shao-Ru Wang et al.

Nature communications, 11(1), 91-91 (2020-01-05)

Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR

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