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1,1-Dimethylbiguanide hydrochloride


Fórmula lineal:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Número de CAS:
Peso molecular:
Número de EC:
Número MDL:
ID de la sustancia en PubChem:






223-226 °C (lit.)

SMILES string




InChI key


Gene Information

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Descripción general

1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes. Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method. Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans.


1,1-Dimethylbiguanide hydrochloride is suitable biguanide agent used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels. It may be used in the synthesis of the following:
  • bis(1,1-dimethylbiguanido)copper(II) octahydrate
  • bis(1,1-dimethylbiguanido)nickel(II)
  • 1,1-dimethylbiguanidium tetrabromothallate(III)


5 g in glass bottle

Acciones bioquímicas o fisiológicas

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.


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Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids



Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What solvents can be used to dissolve Product D150959, 1,1-Dimethylbiguanide hydrochloride?

    According to the chemicals encyclopedia published by the Royal Society of Chemistry, 1,1-dimethylbiguanide hydrochloride is expected to be soluble in water, or in 95% alcohol.

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1,1-Dimethylbiguanidium tetrabromothallate (III).
He Z, et al.
Acta Crystallographica Section E, Structure Reports Online, 58(11), m647-m649 (2002)
Bis (1, 1-dimethylbiguanido) nickel (II).
Zhu M, et al.
Acta Crystallographica Section E, Structure Reports Online, 58(6), 272-274 (2002)
Nobuyuki Yasuda et al.
Biochemical and biophysical research communications, 298(5), 779-784 (2002-11-07)
Metformin was reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans. There are two possible mechanisms for this effect: (1) metformin inhibits dipeptidyl peptidase IV (DPPIV), an enzyme degrading GLP-1, and (2) metformin enhances GLP-1 secretion. To elucidate the
Bis (1,1-dimethylbiguanido) copper (II) octahydrate.
Zhu M, et al.
Acta Crystallographica Section E, Structure Reports Online, 58(5), 217-219 (2002)
Hui-Ying Tsai et al.
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Maple syrup urine disease (MSUD) is an inherited error in the metabolism of branched-chain amino acids (BCAAs) caused by a severe deficiency of the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, which ultimately leads to neurological disorders. The limited therapies, including protein-restricted


Insulin Signaling and Energy Homeostasis

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Oncogenes and Tumor Suppressors Reprogram Metabolism

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