700040P

desmosterol-d6

cholesta-5,24-dien-3β-ol-d6, powder

• Synonym(s): 24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)
• Empirical Formula (Hill Notation): C₂₇H₃₈OD₆
• CAS Number: 1246298-67-8
• Molecular Weight: 390.67
• NACRES: NA.25

Properties

• ensayo: >99% (TLC)
• formulario: powder
• envase: pkg of 1 × 1 mg (700040P-1mg)
• manufacturer/tradename: Avanti Polar Lipids 700040P
• enviado en: dry ice
• temp. de almacenamiento: −20°C

Description

Descripción general

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

Aplicación

Desmosterol-d6 has been used:

• as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
• as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
• for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

Acciones bioquímicas o fisiológicas

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

Envase

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids