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1 MG
MXP 10,464.00
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Fórmula empírica (notación de Hill):
C27H39O2D7
Número CAS:
Peso molecular:
409.70
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.25
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Servicio técnico
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Permítanos ayudarledescription
cholest-5-en-3β,7β-diol-d7
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700044P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Categorías relacionadas
1 of 4
Este artículo | 700042P | 700014P | 700043P |
|---|---|---|---|
| assay >99% (TLC) | assay >99% (TLC) | assay >99% (TLC) | assay >99% (TLC) |
| form powder | form powder | form powder | form powder |
| packaging pkg of 1 × 1 mg (700044P-1mg) | packaging pkg of 1 × 1 mg (700042P-1mg) | packaging pkg of 1 × 1 mg (700014P-1mg) | packaging pkg of 1 × 1 mg (700043P-1mg) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| description cholest-5-en-3β,7β-diol-d7 | description cholest-5-ene-3,4-diol-d7 | description cholestanol, 5β,6β-epoxy-d7 | description cholest-5-en-3β,7α-diol-d7 |
| manufacturer/tradename Avanti Research™ - A Croda Brand | manufacturer/tradename Avanti Research™ - A Croda Brand | manufacturer/tradename Avanti Research™ - A Croda Brand | manufacturer/tradename Avanti Research™ - A Croda Brand |
General description
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol.[1] 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
Application
7β-hydroxycholesterol-d7 has been used:
- as cholesterol oxidation product for mass spectroscopy analysis[2]
- as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis[3]
- as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry[4]
- as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification[5]
Biochem/physiol Actions
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice.[6] 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.[1]
Packaging
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Clase de almacenamiento
11 - Combustible Solids
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