700053P

25-hydroxycholesterol-d6

cholest-5-ene-3β,25-diol-d6, powder

• Synonym(s): 26,26,26,27,27,27-hexadeuterocholest-5-ene-3β,25-diol; 25-hydroxycholest-5-en-3-ol(d6)
• Empirical Formula (Hill Notation): C₂₇H₄₀D₆O₂
• CAS Number: 88247-69-2
• Molecular Weight: 408.69
• NACRES: NA.25

Properties

• ensayo: >99% (TLC)
• formulario: powder
• envase: pkg of 1 × 1 mg (700053P-1mg)
• manufacturer/tradename: Avanti Polar Lipids 700053P
• enviado en: dry ice
• temp. de almacenamiento: −20°C

Description

Descripción general

25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.

Aplicación

25-hydroxycholesterol-d6 has been used as an internal standard:

• in the quantification of 25-OHC in jejunum samples by liquid chromatography with tandem mass spectrometry (LC-MS-MS)
• in plasma samples by liquid chromatography-mass spectrometry analysis
• for calibration curve generation for plasma oxysterol quantification

Acciones bioquímicas o fisiológicas

25-hydroxycholesterol is a liver X receptor ligand. This bioactive lipid regulates immune response and macrophages production from monocytes. 25-HC serves as an antiviral effector and may have therapeutic potential. It reduces cholesterol biosynthesis by inactivating sterol regulatory element binding protein and inhibits HMG-CoA reductase (HMGCR). 25-HC may play a protective role in myocardial ischemia-reperfusion injury by inhibiting apoptosis and regulating mitogen-activated protein kinase (MAPK) pathway.

Envase

5 mL Amber Glass Screw Cap Vial (700053P-1mg)

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Punto de inflamabilidad F: No data available
• Punto de inflamabilidad C: No data available