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700054P

Avanti

5α,6β-dihydroxycholestanol

Avanti Polar Lipids

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Sinónimos:
3β,5α,6β-trihydroxycholestane
Empirical Formula (Hill Notation):
C27H48O3
Número de CAS:
1253-84-5
Peso molecular:
420.67
NACRES:
NA.25

descripción

Cholestane-3β,5α,6β-triol

Análisis

>99% (TLC)

formulario

powder

envase

pkg of 1 × 25 mg (700054P-25mg)
pkg of 1 × 5 mg (700054P-5mg)

manufacturer/tradename

Avanti Polar Lipids

enviado en

dry ice

temp. de almacenamiento

−20°C

InChI

1S/C27H48O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28-30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,25-,26-,27+/m1/s1

InChI key

YMMFNKXZULYSOQ-RUXQDQFYSA-N

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Este artículo
700055P700013P700012P
5α,6β-dihydroxycholestanol Avanti Polar Lipids

Avanti

700054P

5α,6β-dihydroxycholestanol

5α,6β-dihydroxycholestanol-d7 Avanti Polar Lipids

Avanti

700055P

5α,6β-dihydroxycholestanol-d7

15β-hydroxycholestane Avanti Polar Lipids

Avanti

700013P

15β-hydroxycholestane

15α-hydroxycholestane Avanti Polar Lipids

Avanti

700012P

15α-hydroxycholestane

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 1 mg (700055P-1mg), pkg of 1 × 5 mg (700055P-5mg)

packaging

pkg of 1 × 5 mg (700013P-5mg)

packaging

pkg of 1 × 5 mg (700012P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700054P

manufacturer/tradename

Avanti Polar Lipids 700055P

manufacturer/tradename

Avanti Polar Lipids 700013P

manufacturer/tradename

Avanti Polar Lipids 700012P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Descripción general

5α,6β-dihydroxycholestanol is a structural derivative of cholesterol. It is produced by the low-density lipoprotein oxidation (LDL) and is a cholesterol autooxidation product. 5α,6β-dihydroxycholestanol is an abundant oxysterol.

Aplicación

5α,6β-dihydroxycholestanol has been used as a cholesterol oxidation product in reversed phase chromatography (RP-HPLC) and mass spectroscopy analysis. It may be used as an internal standard in tandem mass spectrometry (MS/MS analysis) of plasma samples.

Acciones bioquímicas o fisiológicas

5α,6β-dihydroxycholestanol (5α,6α-diOH-Chol) or cholestan-3β,5α,6β-triol (C-triol) levels are elevated along with 7-ketocholesterol in Niemann-Pick type C (NP-C) disease and is a key biomarkers for detection. It exhibits neuroprotective functionality during central nervous system (CNS) ischemia.

Envase

5 mL Amber Glass Screw Cap Vial (700054P-25mg)
5 mL Amber Glass Screw Cap Vial (700054P-5mg)

también adquirido normalmente con este producto

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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Referencia del producto
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Haiyan Hu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11426-11438 (2014-08-22)
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death of the CNS in various disorders, including cerebral and spinal cord ischemia. However, the intrinsic and physiological mechanisms of modulation of these receptors are essentially unknown. Here
Sara Boenzi et al.
Journal of lipid research, 57(3), 361-367 (2016-01-07)
Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions. Cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC) have been proposed as new biomarkers for the diagnosis of Niemann-Pick type C (NP-C)
Ren Sheng et al.
Nature communications, 5, 4393-4393 (2014-07-16)
Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the
M Voorink-Moret et al.
Molecular genetics and metabolism, 123(2), 76-84 (2018-01-02)
In patients suspected of a lipid storage disorder (sphingolipidoses, lipidoses), confirmation of the diagnosis relies predominantly on the measurement of specific enzymatic activities and genetic studies. New UPLC-MS/MS methods have been developed to measure lysosphingolipids and oxysterols, which, combined with
G J Schroepfer
Physiological reviews, 80(1), 361-554 (2000-01-05)
Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation. The most notable oxysterol activities center around the regulation of cholesterol homeostasis, which appears to be
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