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700054P

Avanti

5α,6β-dihydroxycholestanol

Avanti Research™ - A Croda Brand

Sinónimos:

3β,5α,6β-trihydroxycholestane

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Tamaño de envaseSKUDisponibilidadPrecio
5 mg
Comprobar disponibilidad del carrito
MXP 2,498.00
25 mg
Comprobar disponibilidad del carrito
MXP 9,385.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C27H48O3
Número CAS:
1253-84-5
Peso molecular:
420.67
MDL number:
MFCD00021171
UNSPSC Code:
12352211
NACRES:
NA.25

MXP 2,498.00

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description

Cholestane-3β,5α,6β-triol

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@]21[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)C[C@H]2O)(CC[C@@H](C1)O)C

InChI

1S/C27H48O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28-30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,25-,26-,27+/m1/s1

InChI key

YMMFNKXZULYSOQ-RUXQDQFYSA-N

General description

5α,6β-dihydroxycholestanol is a structural derivative of cholesterol.[1] It is produced by the low-density lipoprotein oxidation (LDL) and is a cholesterol autooxidation product.[2] 5α,6β-dihydroxycholestanol is an abundant oxysterol.[3]

Application

5α,6β-dihydroxycholestanol has been used as a cholesterol oxidation product in reversed phase chromatography (RP-HPLC) and mass spectroscopy analysis.[4] It may be used as an internal standard in tandem mass spectrometry (MS/MS analysis) of plasma samples.[5]

Biochem/physiol Actions

5α,6β-dihydroxycholestanol (5α,6α-diOH-Chol) or cholestan-3β,5α,6β-triol (C-triol) levels are elevated along with 7-ketocholesterol in Niemann-Pick type C (NP-C) disease and is a key biomarkers for detection.[6] It exhibits neuroprotective functionality during central nervous system (CNS) ischemia.[3]

Packaging

5 mL Amber Glass Screw Cap Vial (700054P-25mg)
5 mL Amber Glass Screw Cap Vial (700054P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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5α,6β-dihydroxycholestanol Avanti Research™ - A Croda Brand

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5α,6β-dihydroxycholestanol

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700033P

5β,6β-epoxycholestanol

4β-hydroxycholesterol Avanti Research™ - A Croda Brand

Avanti

700036P

4β-hydroxycholesterol

5α,6α-epoxycholestanol Avanti Research™ - A Croda Brand

Avanti

700032P

5α,6α-epoxycholestanol

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 5 mg (700033P-5mg)

packaging

pkg of 1 × 10 mg (700036P-10mg), pkg of 1 × 5 mg (700036P-5mg)

packaging

pkg of 1 × 5 mg (700032P-5mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

form

powder

form

powder

form

powder

form

powder

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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M Voorink-Moret et al.
Molecular genetics and metabolism, 123(2), 76-84 (2018-01-02)
In patients suspected of a lipid storage disorder (sphingolipidoses, lipidoses), confirmation of the diagnosis relies predominantly on the measurement of specific enzymatic activities and genetic studies. New UPLC-MS/MS methods have been developed to measure lysosphingolipids and oxysterols, which, combined with
Haiyan Hu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11426-11438 (2014-08-22)
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death of the CNS in various disorders, including cerebral and spinal cord ischemia. However, the intrinsic and physiological mechanisms of modulation of these receptors are essentially unknown. Here
Sara Boenzi et al.
Journal of lipid research, 57(3), 361-367 (2016-01-07)
Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions. Cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC) have been proposed as new biomarkers for the diagnosis of Niemann-Pick type C (NP-C)
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SKUGTIN
700054P-5MG04061835384648
700054P-25MG04061835384631