700056P

lathosterol-d7

Avanti Polar Lipids 700056P, powder

• Synonym(s): 5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)
• Empirical Formula (Hill Notation): C₂₇H₃₉D₇O
• CAS Number: 2260669-10-9
• Molecular Weight: 393.70
• NACRES: NA.25

Properties

• ensayo: >99% (TLC)
• formulario: powder
• envase: pkg of 1 × 1 mg (700056P-1mg)
• manufacturer/tradename: Avanti Polar Lipids 700056P
• enviado en: dry ice
• temp. de almacenamiento: −20°C

Description

Descripción general

Lathosterol is a metabolite of cholesterol present in human breast milk. Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol. Lathosterol-d7 is a deuterated derivative of lathosterol.

Aplicación

Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.

Acciones bioquímicas o fisiológicas

Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis. The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.

Envase

5 mL Amber Glass Screw Cap Vial (700056P-1mg)

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Punto de inflamabilidad F: No data available
• Punto de inflamabilidad C: No data available