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700056P

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lathosterol-d7

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Sinónimos:

5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)

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About This Item

Fórmula empírica (notación de Hill):
C27H39D7O
Número de CAS:
2260669-10-9
Peso molecular:
393.70
Número MDL:
MFCD22416731
Código UNSPSC:
41141804
NACRES:
NA.25
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Ensayo

>99% (TLC)

Formulario

powder

envase

pkg of 1 × 1 mg (700056P-1mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

Lathosterol is a metabolite of cholesterol present in human breast milk.[1] Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol.[2] Lathosterol-d7 is a deuterated derivative of lathosterol.

Aplicación

Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification[1] and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.[3]

Acciones bioquímicas o fisiológicas

Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis.[4] The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.[2]

Envase

5 mL Amber Glass Screw Cap Vial (700056P-1mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Punto de inflamabilidad (°F)

No data available

Punto de inflamabilidad (°C)

No data available

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Patrycja A Krakowiak et al.
Human molecular genetics, 12(13), 1631-1641 (2003-06-19)
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Monica Gelzo et al.
Lipids in health and disease, 18(1), 235-235 (2020-01-01)
Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively. The age of the patients suspected of having these disorders is highly variable due to the
Andrea Civra et al.
The Journal of steroid biochemistry and molecular biology, 193, 105424-105424 (2019-07-16)
Oxysterols are cholesterol oxidation derivatives. Those containing an additional hydroxyl group on the side chain of the cholesterol molecule result from a physiological enzymatic synthesis and include the majority of oxysterols present in the circulation. Among these, 25-hydroxycholesterol (25OHC) and

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