Merck

700059P

Avanti

27-hydroxycholesterol-d6

Avanti Polar Lipids

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Sinónimos:
25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol; 27-hydroxycholest-5-en-3-ol(d6); 111011
Empirical Formula (Hill Notation):
C27H40D6O2
Número de CAS:
Peso molecular:
408.69
NACRES:
NA.25

descripción

25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol

Análisis

>99% (TLC)

formulario

powder

envase

pkg of 1 × 1 mg (700059P-1mg)

manufacturer/tradename

Avanti Polar Lipids

enviado en

dry ice

temp. de almacenamiento

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@]([2H])(C([2H])([2H])[2H])C(O)([2H])[2H]

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Este artículo
LM4114700078P700136P
27-hydroxycholesterol-d6 Avanti Polar Lipids

Avanti

700059P

27-hydroxycholesterol-d6

27-hydroxycholesterol (D6) Avanti Polar Lipids LM4114, methanol solution

Avanti

LM4114

27-hydroxycholesterol (D6)

form

powder

form

methanol solution

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700059P-1mg)

packaging

pkg of 1 × 1 mL (LM4114-1EA)

packaging

pkg of 1 × 1 mg (700078P-1mg)

packaging

pkg of 1 × 1 mg (700136P-1mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

description

25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol

description

-

description

7α,25-dihydroxycholesterol-d6

description

-

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids LM4114

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids 700136P

Descripción general

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in the liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis. 27-hydroxycholesterol-d6 is a deuterated form of 27-hydroxycholesterol.

Aplicación

27-hydroxycholesterol-d6 has been used:
  • as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondria samples
  • as an internal standard in gas chromatography-mass spectrometry (GC–MS) for plasma sterol quantification
  • as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis

Acciones bioquímicas o fisiológicas

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

Envase

5 mL Amber Glass Screw Cap Vial (700059P-1mg)

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

No data available

Punto de inflamabilidad C

No data available


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Las referencias de los producto se combinan con los tamaños de envase y las cantidades cuando se muestran en la página web, por ejemplo: T1503-25G. Asegúrese de introducir el número de producto ÚNICAMENTE en el campo del Número de producto (ejemplo: T1503).

Ejemplo

T1503
Referencia del producto
-
25G
Tamaño del envase/cantidad

Otros ejemplos

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

introducir como 1.000309185)

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7-ketocholesterol-d7 Avanti Polar Lipids

Avanti

700046P

7-ketocholesterol-d7

25-Hydroxycholesterol ≥98%

Sigma-Aldrich

H1015

25-Hydroxycholesterol

Sodium methoxide reagent grade, 95%, powder

Sigma-Aldrich

164992

Sodium methoxide

Irundika H K Dias et al.
Redox biology, 16, 139-145 (2018-03-04)
Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7β-OHC and 25-OHC). Oxysterols are more soluble than cholesterol and are reported to exert
Shaneabbas Raza et al.
Cancer cell international, 17, 52-52 (2017-05-16)
For every six men, one will be diagnosed with prostate cancer (PCa) in their lifetime. Estrogen receptors (ERs) are known to play a role in prostate carcinogenesis. However, it is unclear whether the estrogenic effects are mediated by estrogen receptor
Erik R Nelson et al.
Science (New York, N.Y.), 342(6162), 1094-1098 (2013-11-30)
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X
Michihisa Umetani et al.
Cell metabolism, 20(1), 172-182 (2014-06-24)
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1. How 27HC impacts vascular health is unknown. We show that elevations in 27HC
Di Li et al.
Obesity (Silver Spring, Md.), 26(4), 713-722 (2018-02-25)
Although 27-hydroxycholesterol (27-HC) has been reported as a potent regulator of lipid homeostasis, its role in hepatic lipogenesis remains obscure. The present study was designed to investigate the impact of 27-HC on sterol regulatory element-binding protein 1 (SREBP-1) and hepatic

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