700060P

desmosterol

Avanti Polar Lipids

• Synonym(s): 24-dehydrocholesterol; 5,24-cholestadien-3β-ol; 110798
• Empirical Formula (Hill Notation): C₂₇H₄₄O
• CAS Number: 313-04-2
• Molecular Weight: 384.64
• NACRES: NA.25

Properties

• description: 3β-hydroxy-5,24-cholestadiene
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (700060P-10mg); pkg of 1 × 5 mg (700060P-5mg)
• manufacturer/tradename: Avanti Polar Lipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: AVSXSVCZWQODGV-DPAQBDIFSA-N

Description

General description

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

Application

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

Biochem/physiol Actions

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

Packaging

5 mL Amber Glass Screw Cap Vial (700060P-10mg)

5 mL Amber Glass Screw Cap Vial (700060P-5mg)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable